Effects of Pax8 and TTF-1 thyroid transcription factor gene transfer in hepatoma cells: Imaging of functional protein-protein interaction and iodide uptake

Journal of Nuclear Medicine

Volumn 46, Issue 5, 2005, Pages 831-839

  Altmann, Annette ^a,b   Schulz, Ralf B ^a   Glensch, Gabriela ^a,b   Eskerski, Helmut ^a   Zitzmann, Sabine ^a,b   Eisenhut, Michael ^a   Haberkorn, Uwe ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Bioluminescence imaging; Protein protein interaction; Thyroid transcription; Thyroid transcription factors human Pax8 and dog TTF 1

Indexed keywords

ACYLTRANSFERASE INHIBITOR; COTRANSPORTER; FIREFLY LUCIFERASE; HISTONE; IODINE 125; RETROVIRUS VECTOR; SODIUM; THYROGLOBULIN; THYROID PEROXIDASE; THYROID TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR PAX8; TRICHOSTATIN A; DNA BINDING PROTEIN; NUCLEAR PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; PAX8 PROTEIN, CANIS FAMILIARIS; PAX8 PROTEIN, HUMAN; PAX8 PROTEIN, MOUSE; PAX8 PROTEIN, RAT; RADIOACTIVE IODINE; RECOMBINANT PROTEIN; THYROID NUCLEAR FACTOR 1; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; BIOLUMINESCENCE; CAMERA; CONTROLLED STUDY; DEVICE; DRUG UPTAKE; GENE EXPRESSION; GENE TRANSFER; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MORRIS HEPATOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; LUMINESCENCE; METABOLISM; METHODOLOGY; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TRANSFER TECHNIQUES; HUMANS; IODINE RADIOISOTOPES; LIVER NEOPLASMS, EXPERIMENTAL; LUMINESCENT MEASUREMENTS; MICE; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PROTEIN INTERACTION MAPPING; RATS; RECOMBINANT PROTEINS; TISSUE DISTRIBUTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 20644433107     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Damante G, Di Lauro R. Thyroid-specific gene expression. Biochim Biophys Acta. 1994;1218:255-266.
2. Damante G, Tell G, Di Lauro R. A unique combination of transcription factors controls differentiation of thyroid cells. Prog Nucleic Acid Res Mol Biol. 2001;66:307-356.
3. Lazzaro D, Price M, de Felice M, Di Lauro R. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development. 1991;113:1093-1104.
4. Zannini M, Avantaggiato V, Biffali E, et al. TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J. 1997;16:3185-3197.
5. Plachov D, Chowdhury K, Walther C, Simon D, Guenet JL, Gruss P. Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development. 1990;110:643-651.
6. Di Palma T, Nitsch R, Mascia A, Nitsch L, Di Lauro R, Zannini M. The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. J Biol Chem. 2003;278:3395-3402.
7. Zannini M, Francis-Lang H, Plachov D, Di Lauro R. Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters. Mol Cell Biol. 1992;12:4230-4241.
8. Ohno M, Zannini M, Levy O, Carrasco N, di Lauro R. The paired-domain transcription factor Pax8 binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP-dependent transcription. Mol Cell Biol. 1999;19:2051-2060.
9. Espinoza CR, Schmitt TL, Loos U. Thyroid transcription factor 1 and Pax8 synergistically activate the promoter of the human thyroglobulin gene. J Mol Endocrinol. 2001;27:59-67.
10. Bhaumik S, Gambhir SS. Optical imaging of Renilla luciferase reporter gene expression in living mice. Proc Natl Acad Sci USA. 2002;99:377-382.
11. Paulmurugan R, Umezawa Y, Gambhir SS. Noninvasive imaging of protein-protein interactions in living subjects by using reporter protein complementation and reconstitution strategies. Proc Natl Acad Sci USA. 2002;99:15608-15613.
12. Hildebrandt IJ, Iyer M, Wagner E, Gambhir SS. Optical imaging of transferrin targeted PEI/DNA complexes in living subjects. Gene Ther. 2003;10:758-764.
13. Berg V, Vassart G, Christophe D. Identification of a thyroid-specific and cAMP-responsive enhancer in the upstream sequences of the human thyroglobulin promoter. Biochim Biophys Acta. 1996;1307:35-38.
14. Christophe D, Cabrer E, Bacolla A, Targovnik H, Pohl V, Vassart G. An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene. Nucleic Acids Res. 1985;13:5127-5144.
15. Sieger S, Jiang S, Kleinschmidt J, et al. Tumor-specific gene expression using regulatory elements of the glucose transporter isoform 1 gene. Cancer Gene Ther. 2004;11:41-51.
16. Moullier P, Marechal V, Danos O, Heard JM. Continuous systemic secretion of a lysosomal enzyme by genetically modified mouse skin fibroblasts. Transplantation. 1993;56:427-432.
17. Haberkorn U, Henze M, Altmann A, et al. Transfer of the human NaI symporter gene enhances iodide uptake in hepatoma cells. J Nucl Med. 2001;42:317-325.
18. Haberkorn U, Kinscherf R, Kissel M, et al. Enhanced iodide transport after transfer of the human sodium iodide symporter gene is associated with lack of retention and low absorbed dose. Gene Ther. 2003;10:774-780.
19. Poleev A, Fickenscher H, Mundlos S, et al. PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. Development. 1992;116:611-623.
20. Christophe-Hobertus C, van Renterghem P, Pichon E, Christophe D. Expression of a transactivation-deficient form of thyroid transcription factor I decreases the activity of co-transfected thyroglobulin and thyroperoxidase promoters. FEBS Lett. 1996;399:140-142.
21. Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA. 1993;90:8392-8396.
22. Church GM, Gilbert W. Genomic sequencing. Proc Natl Acad Sci USA. 1984;81:1991-1995.
23. Weiss SJ, Philp NJ, Grollman EF. Iodide transport in a continuous line of cultured cells from rat thyroid. Endocrinology. 1984;114:1090-1098.
24. Ray P, Pimenta H, Paulmurugan R, et al. Noninvasive quantitative imaging of protein-protein interactions in living subjects. Proc Natl Acad Sci USA. 2002;99:3105-3110.
25. Werner T. Promoters can contribute to the elucidation of protein function. Trends Biotechnol. 2003;21:9-13.
26. Haberkorn U, Altmann A, Eisenhut M. Functional genomics and proteomics: the role of nuclear medicine. Eur J Nucl Med Mol Imaging. 2002;29:115-132.
27. Ohkubo N, Mitsuda N, Tamatani M, et al. Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway. J Biol Chem. 2001;276:3046-3053.
28. Berg V, Vassart G, Christophe D. A zinc-dependent DNA-binding activity co-operates with cAMP-responsive-element-binding protein to activate the human thyroglobulin enhancer. Biochem J. 1997;323:349-357.
29. Behr M, Schmitt TL, Espinoza CR, Loos U. Cloning of a functional promoter of the human sodium/iodide-symporter gene. Biochem J. 1998;331:359-363.
30. Mascia A, De Felice M, Lipardi C, et al. Transfection of TTF-1 gene induces thyroglobulin gene expression in undifferentiated FRT cells. Biochim Biophys Acta. 1997;1354:171-181.
31. Pasca di Magliano M, Di Lauro R, Zannini M. Pax8 has a key role in thyroid cell differentiation. Proc Natl Acad Sci USA. 2000;97:13144-13149.
32. Struhl G, Struhl K, Macdonald PM. The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell. 1989;57:1259-1273.
33. Struhl G, Johnston P, Lawrence PA. Control of Drosophila body pattern by the hunchback morphogen gradient. Cell. 1992;69:237-249.
34. Yan C, Naltner A, Conkright J, Ghaffari M. Protein-protein interaction of retinoic acid receptor alpha and thyroid transcription factor-1 in respiratory epithelial cells. J Biol Chem. 2001;276:21686-21691.
35. Yi M, Tong GX, Murry B, Mendelson CR. Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary surfactant protein-A (SP-A) gene by thyroid transcription factor-1 (TTF-1). J Biol Chem. 2002;277:2997-3005.
36. De Felice M, Damante G, Zannini M, Francis-Lang H, Di Lauro R. Redundant domains contribute to the transcriptional activity of the thyroid transcription factor 1. J Biol Chem. 1995;270:26649-26656.
37. Brinkmann H, Dahler AL, Popa C, et al. Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts. J Biol Chem. 2001;276:22491-22499.
38. Saunders N, Dicker A, Popa C, Jones S, Dahler A. Histone deacetylase inhibitors as potential anti-skin cancer agents. Cancer Res. 1999;59:399-404.
39. Richon VM, Emiliani S, Verdin E, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci USA. 1998;95:3003-3007.