Weak inhibitors protect cholinesterases from stronger inhibitors (dichlorvos): In vitro effect of tiapride

International Journal of Toxicology

Volumn 24, Issue 2, 2005, Pages 79-86

  Petroianu, Georg A ^a   Schmitt, A ^b   Arafat, K ^a   Hasan, M Y ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Cholinesterase; Dichlorvos; Inhibition; Organophosphate; Pralidoxime; Tiapride

Indexed keywords

ANTIEMETIC AGENT; ATROPINE; CHOLINESTERASE INHIBITOR; DICHLORVOS; DOPAMINE RECEPTOR BLOCKING AGENT; METOCLOPRAMIDE; ORGANOPHOSPHATE INSECTICIDE; OXIME; PROKINETIC AGENT; PYRIDOSTIGMINE; SEROTONIN AGONIST; TIAPRIDE;

ACCIDENT; ARTICLE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ERYTHROCYTE; FEMALE; HUMAN; HUMAN EXPERIMENT; IC 50; INTOXICATION; LD 50; MALE; NORMAL HUMAN; SUICIDE;

ACETYLCHOLINESTERASE; BINDING, COMPETITIVE; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, GAS; DICHLORVOS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; FEMALE; HUMANS; MALE; TIAPRIDE;

EID: 20544460232     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/10915810590921360     Document Type: Article

References (29)

1. Arunlakshana, O., and H. O. Schild. 1959. Some quantitative uses of drug antagonists. Br. J. Pharmacol. 14:48-58.
2. Cheng, H. C. 2001. The power issue: determination of KB or Ki from IC50. A closer look at the Cheng-Prusoff equation, the Schild plot and related power equations. J. Pharmacol. Toxicol. Methods 46:61-71.
3. Dart, R. C., L. R. Goldfrank, P. A. Chyka, D. Lotzer, A. D. Woolf, J. McNally, W. R. Snodgrass, K. R. Olson, E. Scharman, R. J. Geller, D. Spyker, M. Kraft, and R. Lipsy. 2000. Combined evidence-based literature analysis and consensus guidelines for stocking of emergency antidotes in the United States. Ann. Emerg. Med. 36:126-132.
4. Dose, M., and H. W. Lange. 2000. The benzamide tiapride: Treatment of extrapyramidal motor and other clinical syndromes. Pharmacopsychiatry 33:19-27.
5. Ellman, G. L., K. D. Courtney, R. M. Feather-Stone, and V. Andres, Jr. 1961. A new and rapid colorimetric determination of acetyl-cholinesterase activity. Biochem. Pharmacol. 7:88-95.
6. Fontaine J., and J. Reuse. 1980. The effects of substituted benzamides on frog rectus abdominis. Eur. J. Pharmacol. 68:55-60.
7. Gordon, J. J., L. Leadbeater, and M. P. Maidment. 1978. The protection of animals against organophosphate poisoning by pretreatment with a carbamate. Toxicol. Appl. Pharmacol. 43:207-216.
8. Jeyaratnam, J. 1990. Acute pesticide poisoning: A major global health problem. World Health Stat. Q. 43:139-144.
9. Johnson, M. K., D. Jacobsen, T. J. Meredith, P. Eyer, A. J. Heath, D. A. Ligtenstein, T. C. Marrs, L. Szinicz, J. A. Vale, J. A. Haines, et al. 2000. Evaluation of antidotes for poisoning by organophosphourus pesticides. Emerg. Med. 12:22-37.
10. Karalliedde, L. 1999. Organophosphourus poisoning and anaesthesia. Anaesthesia 54:1073-1088.
11. Levine, R. 1991. Recognized and possible effects of pesticides in humans. In Handbook of pesticide toxiclogy, general principles, Vol. 1, ed. W. J. Hayes and E. R. Laws, 275-360. San Diego: Academic Press.
12. Marino, M.T., B. G. Schuster, R. P. Brueckner, E. Lin, A. Kaminskis, and K. C. Lasseter. 1998. Population pharmacokinetics and pharmacodynamics of pyridostigmine bromide for prophylaxis against nerve agents in humans. J. Clin. Pharmacol. 38:227-235.
13. Namba, T. 1971. Cholinesterase inhibition by organophospourus compounds, and its clinical effects. Bull WHO 44:289-307.
14. Namba, T., C. T. Nolle, J. Jackrel, and D. Grob. 1971. Poisoning due to organophosphate insecticides: Acute and chronic manifestations. Am. J. Med. 50:457-492.
15. Norman, T., E. Chiu, R. H. James, and M. S. Gregory. 1987. Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease. Eur. J. Clin. Pharmacol. 32:583-586.
16. Peter, J. V., and A. M. Cherian. 2000. Organic insecticides. Anaesth. Intens. Care 28:11-21.
17. Petroianu, G., K. Arafat, M. Kosanovic, A. Saleh, V. Camasamudram, and M. Hassan. 2003a. In vitro protection of RBC acetylcholinesterase by metoclopramide from inhibition by organophosphates (paraoxon and mipafox). J. Appl. Toxicol. 23:447-451.
18. Petroianu, G., M. Y. Hassan, M. Kosanovic, V. Camasamudram, A. Saleh. 2003b. Metoclopramide protection of cholinesterase from paraoxon inhibition. Vet. Human Toxicol. 45:251-253.
19. Petroianu, G., F. Kuehn, C. Thyes, V. Ewald, and A. Missler. 2003c. In vitro protection of plasma cholinesterases by metoclopramide from inhibition by paraoxon. J. Appl. Toxicol. 23:75-79.
20. Petroianu, G., L. M. Toomes, A. Petroianu, W. Bergeler, and R. Rufer. 1998. Control of blood pressure, heart rate and haematocrit during high-dose intravenous paraoxon exposure in mini pigs. J. Appl. Toxicol. 18:293-298.
21. Rev, E., P. d'Athis, M. O. Richard, D. de Lauture, and G. Olive. 1982. Pharmacokinetics of tiapride and absolute bioavailability of three extravascular forms. Int. J. Clin. Pharmacol. Ther. Toxicol. 20:62-67.
22. Roos, R. A., E. J. de Haas, O. J. Buruma, and F. A. de Wolff. 1986. Pharmacokinetics of tiapride in patients with tardive dyskinesia and Huntington's disease. Eur. J. Clin. Pharmacol. 31:191-194.
23. Scatton, B., C. Cohen, G. Perrault, A. Oblin, Y. Claustre, H. Schoemaker, D. J. Sanger, L. Rouquier, and R. Porsolt. 2001. The preclinical pharmacologic profile of tiapride. Eur. J. Psychiatry 16:29-34.
24. Steele, J. W., D. Faulds, and E. M. Sorkin. 1993. Tiapride: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in geriatric agitation. Drugs Aging 3:460-478.
25. Van Helden, H. P., R. W. Busker, B. P. C. Melchers, P. L. B. Bruijnzeel. 1996. Pharmacological effects of oximes: How relevant are they? Arch. Toxicol. 70:779-786.
26. Van Kampen, E. J., and W. G. Zijlstra. 1961. Standardization of hemoglobinometry II. The hemoglobincyanide method. Clin. Chim. Acta 6:538-544.
27. Wiener, S. W., and R. S. Hoffman. 2004. Nerve agents: A comprehensive review. J. Intens. Care Med. 19:22-37.
28. Worek, F., U. Mast, D. Kiderlen, C. Diepold, and P. Eyer. 1999. Improved determination of acetylcholinesterase activity in human whole blood. Clin. Chim. Acta 288:73-90.
29. Zoch, E. 1971. Die Wirkung organischer Phosphorsäureester bzw. Phosphorsäureester auf versch. Enzyme. Arzneim. Forschung 21:181-187.