A tuneable method for N-debenzylation of benzylamino alcohols

Organic Letters

Volumn 7, Issue 12, 2005, Pages 2361-2364

  Grayson, Elizabeth J ^a,b   Davis, Benjamin G ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; AMINO ACID DERIVATIVE; BENZENE DERIVATIVE; CARBOHYDRATE DERIVATIVE; IODINE DERIVATIVE;

ARTICLE; BENZYLATION; REACTION ANALYSIS;

AMINO ACIDS; AMINO ALCOHOLS; BENZENE DERIVATIVES; CARBOHYDRATES; CHEMISTRY, ORGANIC; MOLECULAR STRUCTURE; SUCCINIMIDES;

EID: 20544457347     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol050624f     Document Type: Article

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23. Interestingly, treatment of 7 with 5 equiv of NIS, followed by 1 equiv of water (2 h when TLC indicated no 7) gave 9 in improved 87% yield (entry 21).
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28. Products detected by TLC not necessarily present in the reaction mixture and may be the result of hydrolysis of intermediates.
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