Studies on the synthesis and in vitro anti-tumor activity of dihydroberberine derivatives

Archives of Pharmacal Research

Volumn 20, Issue 5, 1997, Pages 476-479

  Kim, In Jong ^a   Park, Yea Jin ^a   Kim, Joo Il ^a   Lee, Kyung Tae ^a   Kim, Sin Kyu ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Antiproliperative activity; Dichlorocarbene addition; Dihydroberberine

Indexed keywords

EID: 20544444715     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02973943     Document Type: Article

References (12)

1. Baek, S. H., Han, D. S., Yook, C. N., Kim, Y. C. and Kwak, J. S., Synthesis and Antitumor Activity of Cannabigerol, Arch. Pharm. Res., 19, 228-230 (1996).
2. Castro, J. L., Castedo, L. and Riguera, R., Addition of Dichlorocarbene to Aporphinoids: A New Route to Homoaporphines, Tettrahedron Lett., 26, 1561-1564 (1985).
3. Cho, W. J., Yoo, S. J., Chung, B. H., Choi, B. G., Cheon, S. H., Hwang, S. H., Kim, S. K., Kang, B. H. and Lee, C. O., Synthesis of Benzo[c]phenanthridine Derivatives and their In Vitro Anti-tumor Activities, Arch. Pharm. Res., 19, 321-325 (1996).
4. Chung, K. O., Kim, D. H., Choung, S. Y., Rho, Y. S., and Kim, S. K., Studies on the Synthesis of Berberinephenolbetaine Derivatives and itsBiolo-gical Activity (III), Theses Coll. Kyung Hee Univ., 429-442 (1990).
5. Denizot, F. and Lang, R., Rapid Colorimetric Assay for Cell Growth and Survival: Modifications to the Tetrazolium Dye Procedure Giving Improved Sensitivity and Reliability, J. Immun. Methods, 89, 271-277 (1986).
6. Hanaoka, M., Mukai, C., Nagami, K., Okajima, K., and Yasuda, S., Chemical Transformation of Protoberberine. V. Photochemical Valence Isomerization of Berberinephenolbetaines to 8, 14-Cycloberbines, Versatile Aziridine Derivatives for a Novel and Efficient Entry to Spirobenzylisoquinolines and Benzindenoazepines, Chem. Pharm. Bull., 32, 2230-2240 (1984) and References Cited Therein.
7. Hanaoka, M., Motonishi, T. and Mukai, C., A Biomimetic Synthesis of Oxychelerythrine, Dihydrochelerythrine and Chelerythrine from Berberine, J. Chem. Soc. Perkin Trans. 1, 2253-2256 (1986).
8. Kil, K. S., Yum, Y. N., Seo, S. H. and Lee, K. T., Antitumor Activities of Hypericin as a Protein Tyrosine Kinase Blocker, Arch. Pharm. Res., 19, 490-496 (1996).
9. Kim, S. K., Kim, D. H., Chung, K. H., Hwang, S. H., and Kim, J. H., Synthesis of Protoberberine Related Compounds and Their Antifungal Activities, Yakhak Hoeji, 38, 91-96 (1994).
10. Simeon, S., Rios, J. L. and Villar, A., Pharmacological Activity of Benzophenanthridine and Phenanthridine Alkaloids, Pharmazie, 44, 593-597 (1989).
11. Sufness, M. and Douros, J., In Methods in Cancer Research, De Vita, V. T., Jr., Busch, H., (Eds.), Academic Press: New York, 474 (1979).
12. Woo, S. J., Park, Y. J., Hwang, S. H., Hong, Y. H., Lee, M. S., Kim, D. H., Kim, I. J. and Kim, S. K., Synthesis of Phenolbetaine Derivatives and Their Anti-Cancer Activity: Chemical Transformation of C-ring of Protoberberine, Yakhak Hoeji, 40, 487-490 (1996).