메뉴 건너뛰기




Volumn 1, Issue 1, 2004, Pages 48-55

Technology insight: Targeting of biological molecules for evaluation of high-risk atherosclerotic plaques with magnetic resonance imaging

Author keywords

Atherogenesis; Biological markers; Contrast agents; High risk atherosclerotic plaque; Magnetic resonance imaging

Indexed keywords

BIOLOGICAL MARKER; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 8A; CD36 ANTIGEN; CONTRAST MEDIUM; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRIN; GELATINASE A; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; LIPOPROTEIN; PADGEM PROTEIN; SCAVENGER RECEPTOR; SCLEROPROTEIN; THROMBOPLASTIN; VASCULAR CELL ADHESION MOLECULE 1; VITRONECTIN RECEPTOR;

EID: 20444493524     PISSN: 17434297     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncpcardio0013     Document Type: Review
Times cited : (45)

References (50)
  • 1
    • 2442674610 scopus 로고    scopus 로고
    • Heart Disease and Stroke Statistics - 2004 Update
    • American Heart Association (accessed 11 Aug 04)
    • American Heart Association (2004) Heart Disease and Stroke Statistics - 2004 Update. [http://www.americanheart.org/downloadable/heart/ 1079736729696HDSStats2004UpdateREV3-1904.pdf] (accessed 11 Aug 04)
    • (2004)
  • 2
    • 0033485806 scopus 로고    scopus 로고
    • Hemodynamic shear stress and its role in atherosclerosis
    • Malek AM et al. (1999) Hemodynamic shear stress and its role in atherosclerosis. JAMA 282: 2035-2042
    • (1999) JAMA , vol.282 , pp. 2035-2042
    • Malek, A.M.1
  • 3
    • 0030723041 scopus 로고    scopus 로고
    • Endothelial dysfunction and atherosclerosis
    • Vanhoutte PM (2003) Endothelial dysfunction and atherosclerosis. Eur Heart J 18: E19-29
    • (2003) Eur. Heart J. , vol.18
    • Vanhoutte, P.M.1
  • 4
    • 0025281588 scopus 로고
    • Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells
    • Cushing S et al. (1990) Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. PNAS 87: 5134-5138
    • (1990) PNAS , vol.87 , pp. 5134-5138
    • Cushing, S.1
  • 5
    • 0009627006 scopus 로고
    • Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
    • Goldstein JL et al. (1979) Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci USA 76: 333-337
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 333-337
    • Goldstein, J.L.1
  • 6
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801-809.
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 7
    • 0024330373 scopus 로고
    • Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques
    • Richardson PD et al. (1989) Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques. Lancet 2: 941-944
    • (1989) Lancet , vol.2 , pp. 941-944
    • Richardson, P.D.1
  • 8
    • 0020639814 scopus 로고
    • Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis: Characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi
    • Falk E (1983) Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis: characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi. Br Heart J 50: 127-134
    • (1983) Br. Heart J. , vol.50 , pp. 127-134
    • Falk, E.1
  • 9
    • 1642390201 scopus 로고    scopus 로고
    • Matrix metalloproteinases: A review of their structure and role in acute coronary syndrome
    • Jones CB et al. (2003) Matrix metalloproteinases: a review of their structure and role in acute coronary syndrome. Cardiovasc Res 59: 812-823
    • (2003) Cardiovasc. Res. , vol.59 , pp. 812-823
    • Jones, C.B.1
  • 10
    • 0030897655 scopus 로고    scopus 로고
    • Can receptors be imaged with MRI agents?
    • Nunn AD et al. (1997) Can receptors be imaged with MRI agents? Q J Nucl Med 41: 155-162
    • (1997) Q. J. Nucl. Med. , vol.41 , pp. 155-162
    • Nunn, A.D.1
  • 11
    • 0036794367 scopus 로고    scopus 로고
    • Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations
    • Aime S et al. (2002) Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations. J Magn Reson Imaging 16: 394-406
    • (2002) J. Magn. Reson. Imaging , vol.16 , pp. 394-406
    • Aime, S.1
  • 12
    • 0030895048 scopus 로고    scopus 로고
    • A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
    • Suzuki H et al. (1997) A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386: 292-296
    • (1997) Nature , vol.386 , pp. 292-296
    • Suzuki, H.1
  • 13
    • 0033017738 scopus 로고    scopus 로고
    • Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions
    • Gough PJ et al. (1999) Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions. Arterioscler Thromb Vasc Biol 19: 461-471
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 461-471
    • Gough, P.J.1
  • 14
    • 0032914253 scopus 로고    scopus 로고
    • CD36, a novel receptor for oxidized low-density lipoproteins, is highly expressed on lipid-laden macrophages in human atherosclerotic aorta
    • Nakata A et al. (1999) CD36, a novel receptor for oxidized low-density lipoproteins, is highly expressed on lipid-laden macrophages in human atherosclerotic aorta. Arterioscler Thromb Vasc Biol 19: 1333-1339
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 1333-1339
    • Nakata, A.1
  • 15
    • 0025257041 scopus 로고
    • Ultrasmall superparamagnetic iron oxide: Characterization of a new class of contrast agents for MR imaging
    • Weissleder R et al. (1990) Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 175: 489-493
    • (1990) Radiology , vol.175 , pp. 489-493
    • Weissleder, R.1
  • 16
    • 0023155627 scopus 로고
    • Ferrite particles: A superparamagnetic MR contrast agent for the reticuloendothelial system
    • Saini S et al. (1987) Ferrite particles: a superparamagnetic MR contrast agent for the reticuloendothelial system. Radiology 162: 211-216
    • (1987) Radiology , vol.162 , pp. 211-216
    • Saini, S.1
  • 17
    • 0025253906 scopus 로고
    • Ultrasmall superparamagnetic iron oxide: An intravenous contrast agent for assessing lymph nodes with MR imaging
    • Weissleder R et al. (1990) Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging. Radiology 175: 494-498
    • (1990) Radiology , vol.175 , pp. 494-498
    • Weissleder, R.1
  • 18
    • 0037465804 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide-based method for quantifying recruitment of monocytes to mouse atherosclerotic lesions in vivo: Enhancement by tissue necrosis factor-α, interleukin-1β, and interferon-γ
    • Litovsky S et al. (2003) Superparamagnetic iron oxide-based method for quantifying recruitment of monocytes to mouse atherosclerotic lesions in vivo: enhancement by tissue necrosis factor-α, interleukin-1β, and interferon-γ. Circulation 107: 1545-1549
    • (2003) Circulation , vol.107 , pp. 1545-1549
    • Litovsky, S.1
  • 19
    • 0035928818 scopus 로고    scopus 로고
    • Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall superparamagnetic iron oxide particles
    • Kanno S et al. (2001) Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall superparamagnetic iron oxide particles. Circulation 104: 934-938
    • (2001) Circulation , vol.104 , pp. 934-938
    • Kanno, S.1
  • 20
    • 0035936540 scopus 로고    scopus 로고
    • Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits
    • Ruehm SG et al. (2001) Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits. Circulation 103: 415-422
    • (2001) Circulation , vol.103 , pp. 415-422
    • Ruehm, S.G.1
  • 21
    • 0038179627 scopus 로고    scopus 로고
    • Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging
    • Kooi ME et al. (2003) Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging. Circulation 107: 2453-2458
    • (2003) Circulation , vol.107 , pp. 2453-2458
    • Kooi, M.E.1
  • 22
    • 0037153088 scopus 로고    scopus 로고
    • Noninvasive imaging of oxidized low-density lipoprotein in atherosclerotic plaques with tagged oxidation-specific antibodies
    • Tsimikas S (2002) Noninvasive imaging of oxidized low-density lipoprotein in atherosclerotic plaques with tagged oxidation-specific antibodies. Am J Cardiol 90: 22L-27L
    • (2002) Am. J. Cardiol. , vol.90
    • Tsimikas, S.1
  • 23
    • 0035901582 scopus 로고    scopus 로고
    • Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes
    • Ehara S et al. (2001) Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes. Circulation 103: 1955-1960
    • (2001) Circulation , vol.103 , pp. 1955-1960
    • Ehara, S.1
  • 24
    • 0033033340 scopus 로고    scopus 로고
    • Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo
    • Tsimikas S et al. (1999) Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo. J Nucl Cardiol 6: 41-53
    • (1999) J. Nucl. Cardiol. , vol.6 , pp. 41-53
    • Tsimikas, S.1
  • 25
    • 0034019934 scopus 로고    scopus 로고
    • In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression
    • Tsimikas S et al. (2000) In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression. Arterioscler Thromb Vasc Biol 20: 689-697
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 689-697
    • Tsimikas, S.1
  • 26
    • 20444437456 scopus 로고
    • Requirement of vascular
    • Brooks PC et al. (1994) Requirement of vascular Radiology 221: 237-243
    • (1994) Radiology , vol.221 , pp. 237-243
    • Brooks, P.C.1
  • 27
    • 0028037448 scopus 로고
    • Angiogenesis in human coronary atherosclerotic plaques
    • O'Brien ER et al. (1994) Angiogenesis in human coronary atherosclerotic plaques. Am J Pathol 145: 883-894
    • (1994) Am. J. Pathol. , vol.145 , pp. 883-894
    • O'Brien, E.R.1
  • 28
    • 0242266976 scopus 로고    scopus 로고
    • Molecular imaging of angiogenesis in early-stage atherosclerosis with αvβ3-integrin-targeted nanoparticles
    • Winter PM et al. (2003) Molecular imaging of angiogenesis in early-stage atherosclerosis with αvβ3-integrin-targeted nanoparticles. Circulation 108: 2270-2274
    • (2003) Circulation , vol.108 , pp. 2270-2274
    • Winter, P.M.1
  • 29
    • 0141731298 scopus 로고    scopus 로고
    • Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel αvβ3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging
    • Winter PM et al. (2003) Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel αvβ3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging. Cancer Res 63: 5838-5843
    • (2003) Cancer Res. , vol.63 , pp. 5838-5843
    • Winter, P.M.1
  • 30
    • 0033816877 scopus 로고    scopus 로고
    • Magnetic resonance contrast enhancement of neovasculature with αvβ3-targeted nanoparticles
    • Anderson SA et al. (2000) Magnetic resonance contrast enhancement of neovasculature with αvβ3-targeted nanoparticles. Magn Reson Med 44: 433-439
    • (2000) Magn. Reson. Med. , vol.44 , pp. 433-439
    • Anderson, S.A.1
  • 31
    • 0024336902 scopus 로고
    • Cytochemical changes in a human arterial proteoglycan related to atherosclerosis
    • Volker W et al. (1989) Cytochemical changes in a human arterial proteoglycan related to atherosclerosis. Atherosclerosis 77: 117-130
    • (1989) Atherosclerosis , vol.77 , pp. 117-130
    • Volker, W.1
  • 32
    • 0036791535 scopus 로고    scopus 로고
    • Differential accumulation of proteoglycans and hyaluronan in culprit lesions: Insights into plaque erosion
    • Kolodgie FD et al. (2002) Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion. Arterioscler Thromb Vasc Biol 22: 1642-1648
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 1642-1648
    • Kolodgie, F.D.1
  • 33
    • 0033574256 scopus 로고    scopus 로고
    • Tenascin-C is expressed in macrophage-rich human coronary atherosclerotic plaque
    • Wallner K et al. (1999) Tenascin-C is expressed in macrophage-rich human coronary atherosclerotic plaque. Circulation 99: 1284-1289
    • (1999) Circulation , vol.99 , pp. 1284-1289
    • Wallner, K.1
  • 34
    • 8844277128 scopus 로고    scopus 로고
    • Atheroslcerotic plaque imaging using a novel contrast agent gadofluorine M
    • [Abstract]
    • Aguinaldo JGS et al. (2002) Atheroslcerotic plaque imaging using a novel contrast agent gadofluorine M [Abstract]. Mol Imaging 2: s282
    • (2002) Mol. Imaging , vol.2
    • Aguinaldo, J.G.S.1
  • 35
    • 0041571955 scopus 로고    scopus 로고
    • Detection of atherosclerotic plaque with gadofluorine-enhanced magnetic resonance imaging
    • Barkhausen J et al. (2003) Detection of atherosclerotic plaque with gadofluorine-enhanced magnetic resonance imaging. Circulation 108: 605-609
    • (2003) Circulation , vol.108 , pp. 605-609
    • Barkhausen, J.1
  • 36
    • 2942670674 scopus 로고    scopus 로고
    • Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imaging
    • Sirol M et al. (2004) Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imaging. Circulation 109: 2890-2896
    • (2004) Circulation , vol.109 , pp. 2890-2896
    • Sirol, M.1
  • 37
    • 0028906790 scopus 로고
    • Identification of 92-kD gelatinase in human coronary atherosclerotic lesions: Association of active enzyme synthesis with unstable angina
    • Brown DL et al. (1995) Identification of 92-kD gelatinase in human coronary atherosclerotic lesions: association of active enzyme synthesis with unstable angina. Circulation 91: 2125-2131
    • (1995) Circulation , vol.91 , pp. 2125-2131
    • Brown, D.L.1
  • 38
    • 0035928784 scopus 로고    scopus 로고
    • Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability
    • Cipollone F et al. (2001) Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability. Circulation 104: 921-927
    • (2001) Circulation , vol.104 , pp. 921-927
    • Cipollone, F.1
  • 39
    • 3042716498 scopus 로고    scopus 로고
    • Cellular microparticles: New players in the field of vascular disease?
    • Diamant M et al. (2004) Cellular microparticles: new players in the field of vascular disease? Eur J Clin Invest 34: 392-401
    • (2004) Eur. J. Clin. Invest. , vol.34 , pp. 392-401
    • Diamant, M.1
  • 40
    • 0022523129 scopus 로고
    • Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque
    • Jonasson L et al. (1986) Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis 6: 131-138
    • (1986) Arteriosclerosis , vol.6 , pp. 131-138
    • Jonasson, L.1
  • 41
    • 0032891440 scopus 로고    scopus 로고
    • Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: A role for apoptosis in plaque thrombogenicity
    • Mallat Z et al. (1999) Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity. Circulation 99: 348-353
    • (1999) Circulation , vol.99 , pp. 348-353
    • Mallat, Z.1
  • 42
    • 84858628644 scopus 로고    scopus 로고
    • Inhibition of tissue factor limits the growth of venous thrombus in the rabbit
    • Himber J et al. (2003) Inhibition of tissue factor limits the growth of venous thrombus in the rabbit. J Thromb Haemost 1: 889-895
    • (2003) J. Thromb. Haemost. , vol.1 , pp. 889-895
    • Himber, J.1
  • 43
    • 10744222359 scopus 로고    scopus 로고
    • Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRI
    • Morawski AM et al. (2004) Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRI. Magn Reson Med 51: 480-486
    • (2004) Magn. Reson. Med. , vol.51 , pp. 480-486
    • Morawski, A.M.1
  • 44
    • 0035845635 scopus 로고    scopus 로고
    • Novel MRI contrast agent for molecular imaging of fibrin: Implications for detecting vulnerable plaques
    • Flacke S et al. (2001) Novel MRI contrast agent for molecular imaging of fibrin: implications for detecting vulnerable plaques. Circulation 104: 1280-1285
    • (2001) Circulation , vol.104 , pp. 1280-1285
    • Flacke, S.1
  • 45
    • 0041590985 scopus 로고    scopus 로고
    • Improved molecular imaging contrast agent for detection of human thrombus
    • Winter PM et al. (2003) Improved molecular imaging contrast agent for detection of human thrombus. Magn Reson Med 50: 411-416
    • (2003) Magn. Reson. Med. , vol.50 , pp. 411-416
    • Winter, P.M.1
  • 46
    • 0033646270 scopus 로고    scopus 로고
    • High-resolution MRI characterization of human thrombus using a novel fibrin-targeted paramagnetic nanoparticle contrast agent
    • Yu X et al. (2000) High-resolution MRI characterization of human thrombus using a novel fibrin-targeted paramagnetic nanoparticle contrast agent. Magn Reson Med 44: 867-872
    • (2000) Magn. Reson. Med. , vol.44 , pp. 867-872
    • Yu, X.1
  • 47
    • 0034830512 scopus 로고    scopus 로고
    • USPIO-enhanced direct MR imaging of thrombus: Preclinical evaluation in rabbits
    • Schmitz SA et al. (2001) USPIO-enhanced direct MR imaging of thrombus: preclinical evaluation in rabbits. Radiology 221: 237-243
    • (2001) Radiology , vol.221 , pp. 237-243
    • Schmitz, S.A.1
  • 48
    • 0035078709 scopus 로고    scopus 로고
    • A targeted contrast agent for magnetic resonance imaging of thrombus: Implications of spatial resolution
    • Johansson LO et al. (2001) A targeted contrast agent for magnetic resonance imaging of thrombus: implications of spatial resolution. J Magn Reson Imaging 13: 615-618
    • (2001) J. Magn. Reson. Imaging , vol.13 , pp. 615-618
    • Johansson, L.O.1
  • 49
    • 1542283700 scopus 로고    scopus 로고
    • Seeing within: Molecular imaging of the cardiovascular system
    • Jaffer FA and Weissleder R (2004) Seeing within: molecular imaging of the cardiovascular system. Circ Res 94: 433-445
    • (2004) Circ. Res. , vol.94 , pp. 433-445
    • Jaffer, F.A.1    Weissleder, R.2
  • 50
    • 3142574756 scopus 로고    scopus 로고
    • Detection of arterial thrombi in vivo by MRI using a fibrin-targeted contrast agent
    • [Abstract II-435]
    • Fayad ZA et al. (2002) Detection of arterial thrombi in vivo by MRI using a fibrin-targeted contrast agent [Abstract II-435]. Circulation 106
    • (2002) Circulation , vol.106
    • Fayad, Z.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.