Distinct conformation-mediated functions of an active site loop in the catalytic reactions of NAD-dependent D-lactate dehydrogenase and formate dehydrogenase

Journal of Biological Chemistry

Volumn 280, Issue 17, 2005, Pages 17068-17075

  Shinoda, Takeshi ^a   Arai, Kazuhito ^a   Shigematsu Iida, Mayu ^a   Ishikura, Yoshirou ^a   Tanaka, Satoru ^a   Yamada, Takashi ^a   Kimber, Matthew S ^b   Pai, Emil F ^c   Fushinobu, Shinya ^d   Taguchi, Hayao ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b Affinium Pharmaceuticals   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ENGINEERING; MOLECULAR STRUCTURE; PROTEINS; SULFONATION; X RAY CRYSTALLOGRAPHY;

CELL SURFACE PROTEIN; ENDOCYTOSIS; FORMATE DEHYDROGENASE (FDH); PRION-INFECTED MATERIAL;

ENZYMES;

ASPARAGINE; FORMATE DEHYDROGENASE; GLUTAMINE; GLYOXYLIC ACID; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRUVIC ACID; D-LACTATE DEHYDROGENASE; DEXTRO LACTATE DEHYDROGENASE; GLUTAMIC ACID; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXYGEN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; HYDROGEN BOND; LACTOBACILLUS; LACTOBACILLUS PENTOSUS; NONHUMAN; OPTICAL RESOLUTION; PARACOCCUS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; REACTION ANALYSIS; THREE DIMENSIONAL IMAGING; WILD TYPE; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ENZYME SPECIFICITY; ENZYMOLOGY; KINETICS; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS;

LACTOBACILLUS PENTOSUS; PARACOCCUS SP. 12-A;

AMINO ACID SEQUENCE; ASPARAGINE; BASE SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMATE DEHYDROGENASES; GLUTAMIC ACID; HYDROGEN BONDING; KINETICS; LACTATE DEHYDROGENASES; LACTIC ACID; LACTOBACILLUS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NADP; OXYGEN; PARACOCCUS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 20444474123     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500970200     Document Type: Article

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