MAPK and PI3K inhibition reduces proliferation of Barrett's adenocarcinoma in vitro

Journal of Surgical Research

Volumn 127, Issue 1, 2005, Pages 53-57

  Vona Davis, Linda ^a   Frankenberry, Krista ^a   Cunningham, Cynthia ^b   Riggs, Dale R ^a   Jackson, Barbara J ^a   Szwerc, Michael F ^a   McFadden, David W ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Apoptosis; Barrett's adenocarcinoma; MAPK; PI3 kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN P53;

ANALYSIS OF VARIANCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BARRETT ESOPHAGUS; CANCER CELL CULTURE; CELL ACTIVITY; CELL ASSAY; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONFERENCE PAPER; ENZYME INHIBITION; ESOPHAGEAL ADENOCARCINOMA; IN VITRO STUDY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; WILD TYPE;

EID: 20444468484     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jss.2005.03.013     Document Type: Conference Paper

References (21)

1. A. Jemal, T. Murray, A. Samuels Cancer statistics, 2003 CA Cancer J. Clin. 53 2003 5
2. T.R. DeMeester Barrett's esophagus Surgery 113 1993 239
3. O.S. Soldes, R.D. Kuick, I.A. Thompson Differential expression of Hsp27 in normal oesophagus, Barrett's metaplasia and oesophageal adenocarcinomas Br. J. Cancer 79 1999 595
4. M.T. Yip-Schneider, C.A. Wiesenauer, C.M. Schmidt Inhibition of the phosphatidylinositol 3′-kinase signaling pathway increases the responsiveness of pancreatic carcinoma cells to sulindac J. Gastrointest. Surg. 7 2003 354
5. V.M. Bondar, B. Sweeney-Gotsch, M. Andreeff Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo Mol. Cancer Ther. 1 2002 989
6. S.S.W. Ng, M.S. Tsao, S. Chow Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells Cancer Res. 60 2000 5451
7. R.F. Souza, K. Shewmake, L.S. Terada Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's esophagus Gastroenterology 122 2002 299
8. T. Akimoto, T. Nonaka, K. Harashima Selective inhibition of survival signal transduction pathways enhanced radiosensitivity in human esophageal cancer cell lines in vitro Anticancer Res. 24 2004 811
9. P. Somasundar, D. Riggs, B. Jackson Leptin stimulates esophageal adenocarcinoma growth by nonapoptotic mechanisms Am. J. Surg. 186 2003 575
10. P. Somasundar, A.K. Yu, L. Vona-Davis Differential effects of leptin on cancer in vitro J. Surg. Res. 113 2003 50
11. T.T. Tsai, P.F. Bongiorno, M.B. Orringer Detection of p53 nuclear protein accumulation in brushings and biopsies of Barrett's esophagus Cancer Detect. Prev. 21 1997 326
12. R.F. Souza, K. Shewmake, D.G. Beer Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells Cancer Res. 60 2000 5767
13. D.W. McFadden, D.R. Riggs, B.J. Jackson Keyhole limpet hemocyanin, a novel immune stimulant with promising anticancer activity in Barrett's esophageal adenocarcinoma Am. J. Surg. 186 2003 552
14. D.M. Nguyen, G.A. Chen, R. Reddy Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway J. Thorac. Cardiovasc. Surg. 127 2004 365
15. D.G. Beer, G.D. Stoner Clinical models of chemoprevention for the esophagus Hematol. Oncol. Clin. North Am. 12 1998 1055
16. C. Mariette, L. Finzi, G. Piessen Esophageal carcinoma prognostic differences between squamous cell carcinoma and adenocarcinoma World J. Surg. 29 2005 39
17. K. Jaiswal, V. Tello, C. Lopez-Guzman Bile salt exposure causes phosphatidyl-inositol-3-kinase-mediated proliferation in a Barrett's adenocarcinoma cell line Surgery 136 2004 160
18. M.I. Auvinen, E.I. Sihvo, T. Ruohtula Incipient angiogenesis in Barrett's epithelium and lymphangiogenesis in Barrett's adenocarcinoma J. Clin. Oncol. 20 2002 2971
19. M.T. Yip-Schneider, C.M. Schmidt MEK inhibition of pancreatic carcinoma cells by U0126 and its effect in combination with sulindac Pancreas 27 2003 337
20. C.M. Schmidt, Y. Wang, C. Wiesenauer Novel combination of cyclooxygenase-2 and MEK inhibitors in human hepatocellular carcinoma provides a synergistic increase in apoptosis J. Gastrointest. Surg. 7 2003 1024
21. L. Vona-Davis, D.R. Riggs, B.J. Jackson Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro(1) J. Surg. Res. 119 2004 143