Fancy bioisosteres: Synthesis, SAR, and pharmacological investigations of novel nonaromatic dopamine D3 receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 14, 2005, Pages 4434-4442

  Lenz, Carola ^a   Boeckler, Frank ^a   Hübner, Harald ^a   Gmeiner, Peter ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

D3; Dopamine; Fancy bioisosteres; Palladium catalyzed cross coupling

Indexed keywords

1 [2 (TRIMETHYLSILYLETHYNYL) 5 (DIPROPYLAMINO)CYCLOHEX 1 EN 1 YL]ETHANONE; 2 (TRIMETHYLSILYLETHYNYL) 5 (DIPROPYLAMINO)CYCLOHEX 1 EN 1 CARBALDEHYDE; 2 ETHYNYL 5 (DIPROPYLAMINO)CYCLOHEX 1 ENE 1 CARBALDEHYDE; ALKADIENE; ALKYNE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; DIPROPYL (4 ETHYNYL 3 VINYLCYCLOHEX 3 EN 1 YL)AMINE; DIPROPYL[4 (TRIMETHYLSILYLETHYNYL) 3 VINYLCYCLOHEX 3 EN 1 YL]AMINE; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; FAUC 88; METHYL 2 (3 HYDROXYPROP 1 YN 1 YL) 5 (DIPROPYLAMINO)CYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 2 (TRIMETHYLSILYLETHYNYL) 5 (DIPROPYLAMINO)CYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 2 CYANO 5 (DIPROPYLAMINO)CYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 2 ETHYNYL 5 (DIPROPYLAMINO)CYCLOHEX 1 ENE 1 CARBOXYLATE; PALLADIUM; RECEPTOR SUBTYPE; TRIMETHYLSILYL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; CATALYSIS; CHEMICAL REACTION; COMPARATIVE STUDY; DENSITY FUNCTIONAL THEORY; GEOMETRY; NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; CORPUS STRIATUM; MAGNETIC RESONANCE SPECTROSCOPY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 20444468075     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.04.047     Document Type: Article

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