Urokinase-induced smooth muscle cell migration requires PI3-K and Akt activation

Journal of Surgical Research

Volumn 127, Issue 1, 2005, Pages 46-52

  Galaria, Irfan I ^a   Nicholl, Suzanne M ^a   Roztocil, Elisa ^a   Davies, Mark G ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

akt; ATF; Cell signaling; Migration; PI3K; Smooth muscle cell; Urokinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; GLYCOGEN SYNTHASE KINASE 3BETA; MANUMYCIN; MANUMYCIN A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; UROKINASE; WORTMANNIN;

AMINO TERMINAL SEQUENCE; ANALYSIS OF VARIANCE; ANIMAL CELL; ARTERY MUSCLE; CELL MIGRATION; CELL STIMULATION; CHEMOTAXIS; CONFERENCE PAPER; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TIME; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; AORTA; CELL MOVEMENT; CELLS, CULTURED; CHEMOTAXIS; CHROMONES; ENZYME ACTIVATION; ENZYME INHIBITORS; MICE; MORPHOLINES; MUSCLE, SMOOTH, VASCULAR; PEPTIDE FRAGMENTS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 20444467261     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jss.2005.02.022     Document Type: Conference Paper

References (32)

1. M.G. Davies, P.-O. Hagen Pathobiology of intimal hyperplasia Br. J. Surg. 81 1994 1254
2. F. Blasi, P. Carmeliet uPAR A versatile signaling orchestrator Nat. Cell Biol. 3 2002 932
3. V. Stepanova, S. Mukhina, E. Kohler, T.J. Resink, P. Erne, V.A. Tkachuk Urokinase plasminogen activator induces human smooth muscle cell migration and proliferation via distinct receptor dependent and proteolysis-dependent mechanisms Mol. Cell Biochem. 195 1999 199
4. D.H. Nguyen, I.M. Hussaini, S.L. Gonias binding of uPA to its receptor in MCF-7 cells activates ERK1 and 2 which is required for increased motility J. Biol. Chem. 273 1998 8502
5. M. Resnati, I. Pallavicini, J.M. Wang The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R Proc. Natl. Acad. Sci. USA 99 2002 1359
6. W.J. Tanski, A.J. Fegley, E. Roztocil, M.G. Davies Domain dependent actions of urokinase on smooth muscle cell responses J. Vasc. Surg. 39 2004 214
7. J.A.F. Vara, E. Casado, J. deCastro, P. Cejas, C. Belda-Iniesta, M. Gonzalez-Baron PI3K/akt signalling pathway and cancer Cancer Treatment Rev. 30 2004 193
8. P. Blume-Jensen, T. Hunter Oncogenic kinase signalling Nature 411 2001 355
9. M. Fukata, M. Nakagawa, K. Kaibuchi Role of rho-family GTPase in cell polarization and directional migration Curr. Opin. Cell Biol. 15 2003 590
10. MAPK activation J. Surg. Res. 113 2003 32
11. A. Albini, Y. Iwamoto, H.K. Kleinman A rapid in vitro assay for quantitating the invasive potential of tumor cells Cancer Res. 47 1987 3239
12. R. Forough, N. Koyama, D. Hasentaub Overexpression of TIMP-1 inhibits vascular smooth muscle cell formation in vitro and in vivo Circ. Res. 79 1996 812
13. S. Lilly, G. Daum, M.M. Clowes, A.W. Clowes The regulation of p42/p44 MAPKs in the injured rat carotid artery J. Surg. Res. 70 1997 178
14. F. Sanchez-Madrid, M.A. Del-Pozo Leukocyte polarization in cell migration and immune interactions EMBO J. 18 1999 501
15. M.P. Wymann, M. Zvelebil, M. Laffargue Phosphoinositide 3 kinase signalling Which way to target? Trends Pharmacol. Sci. 24 2003 366
16. W.J. Tanski, E. Roztocil, M.G. Davies Sphingosine-1-phosphate induces Gαi-coupled, PI3K/ras dependent smooth muscle cell migration J. Surg. Res. 108 2002 98
17. D. Lauffenberger, A. Horwitz Cell migration A physically integrated molecular process Cell 84 1996 359
18. S. Etienne-Manneville, A. Hall cdc42 regulates GSK3beta and adenomatous polyposis coli to control cell polarity Nature 421 2003 753
19. T. Jimbo, Y. Kawasaki, R. Koyama Identification of a link between the tumor suppressor APC and the kinesin superfamily Nat. Cell Biol. 4 2002 323
20. Y. Kawaski, T. Senda, T. Ishidate Asef a link between the tumor suppressor APC and G-protein signaling Science 289 2000 1194
21. V.A. Korshunov, B.C. Berk Flow-induced vascular remodeling in the mouse A model for carotid intima-media thickening Arterioscler. Thromb. Vasc. Biol. 23 2003 2185
22. V.A. Korshunov, M.A. Solomatina, O.S. Plekhanova, Y.V. Parfyonova, V.A. Tkachuk, B.C. Berk Plasminogen activator expression correlates with genetic differences in vascular remodeling J. Vasc. Res. 41 2004 481
23. B.H. Strauss, H.K. Lau, K.A. Bowman Plasma urokinase antigen and PAI-1 antigen levels predict angiographic coronary restenosis Circulation 100 1999 1616
24. A.W. Clowes, M.A. Reidy, M.M. Clowes, D. Belin Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid Circ. Res. 67 1990 61
25. M.A. Reidy, C. Irvin, V. Lindner Migration of arterial wall cells. Expression of Plasminogen activators and inhibitors in injured rat arteries Circ. Res. 78 1996 405
26. V. Stepanova, A. Bobik, R. Bibilashvity Urokinase plasminogen activator induces smooth muscle cell migration Key role of growth factor-like domain FEBS Lett. 414 1997 471
27. J.M. Herbert, I. Lamarche, P. Carmeliet Urokinase and tissue-type plasminogen activator are required for the mitogenic and chemotactic effects of bovine fibroblast growth factor and platelet-derived growth factor-BB for vascular smooth muscle cells J. Biol. Chem. 272 1997 23585
28. S.M. Nicholl, E. Roztocil, M.G. Davies Urokinase (uPA) induced smooth muscle cell responses require distinct signaling pathways A role for the epidermal growth factor receptor J. Vasc. Surg. 2005 in press
29. F. Blasi, J.-D. Vassalli, K. Dang Urokinase type plasminogen activator Proenzyme, receptor and inhibitors J. Cell. Biol. 104 1987 801
30. F. Blasi The urokinase receptor A cell surface regulated chemokine APMIS 107 1999 96
31. F. Blasi Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the u-PA-u-PAR-PAI-1 system Thromb. Haemost. 82 1999 298
32. K. Shigematsu, H. Koyama, E.N. Olson, A. Cho, M.A. Reidy Phosphatidylinositol 3-Kinase signaling is important for smooth muscle cell replication after arterial injury Arterioscler. Thromb. Vasc. Biol. 20 2000 2373