Plasmin induces smooth muscle cell proliferation

Journal of Surgical Research

Volumn 127, Issue 1, 2005, Pages 39-45

  Nicholl, Suzanne M ^a   Roztocil, Elisa ^a   Galaria, Irfan I ^a   Davies, Mark G ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

akt; Cell signaling; MAPK; PI3K; Plasmin; Proliferation; Smooth muscle cell

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMINOCAPROIC ACID; APROTININ; CELL DNA; MANUMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLASMIN; PLASMIN INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; SYNAPTOPHYSIN; WORTMANNIN;

ANIMAL CELL; AORTA MEDIA; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DNA DETERMINATION; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANIMALS; APROTININ; CELL DIVISION; CELLS, CULTURED; DNA REPLICATION; ENZYME ACTIVATION; KINETICS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH; PHOSPHORYLATION; PLASMIN; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 20444451643     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jss.2005.03.004     Document Type: Conference Paper

References (19)

1. M.G. Davies, D.E. Lee, R.M. Green Current spectrum of thrombolysis W. Moore S. Ahn Endovascular Surgery 3rd ed 2001 WB Saunders Philadelphia, Pa 255 274
2. Y. Parfyonova, O. Plekhanova, M. Solomatina Contrasting effects of urokinase and tissue type plasminogen activator on neointima formation and vessel remodeling after arterial injury J. Vasc. Res. 41 2004 268
3. U.R. Pendurthi, M. Ngyuen, P. Andrade-Gordon, L.C. Petersen, L.V. Rao Plasmin induces Cyr61 gene expression in fibroblasts via protease-activated receptor-1 and p44/42 mitogen-activated protein kinase-dependent signaling pathway Arterioscler. Thromb. Vasc. Biol. 22 2002 1421
4. M.D. Morasch, G.C. Zenni, P.B. Dobrin, R. Mrkvicka Intimal hyperplasia following thrombectomy versus thrombolysis in occluded vein grafts Ann. Vasc. Surg. 11 1997 559
5. V. Stepanova, A. Bobik, R. Bibilashvity Urokinase plasminogen activator induces smooth muscle cell migration Key role of growth factor-like domain FEBS Lett. 414 1997 471
6. J.M. Herbert, I. Lamarche, P. Carmeliet Urokinase and tissue-type plasminogen activator are required for the mitogenic and chemotactic effects of bovine fibroblast growth factor and platelet-derived growth factor-BB for vascular smooth muscle cells J. Biol. Chem. 272 1997 23585
7. T. Padro, R.M. Mesters, B. Dankbar The catalytic domain of endogenous urokinase-type plasminogen activator is required for the mitogenic activity of platelet derived and basic fibroblast growth factors in human vascular smooth muscle cells J. Cell. Sci. 115 2002 1961
8. F. Blasi The urokinase receptor A cell surface regulated chemokine APMIS 107 1999 96
9. W.J. Tanski, A.J. Fegley, E. Roztocil, M.G. Davies Domain dependent actions of urokinase on smooth muscle cell responses J. Vasc. Surg. 39 2004 214
10. MAPK activation J. Surg. Res. 113 2003 32
11. B.H. Strauss, H.K. Lau, K.A. Bowman Plasma urokinase antigen and PAI-1 antigen levels predict angiographic coronary restenosis Circulation 100 1999 1616
12. A.W. Clowes, M.A. Reidy, M.M. Clowes, D. Belin Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid Circ. Res. 67 1990 61
13. P. Carmeliet, L. Moons, J.-M. Herbert Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice Circ. Res. 81 1997 829
14. H.R. Lijnen, B. VanHoef, F. Lupu, L. Moon, P. Carmeliet, D. Collen Function of the plasminogen/plasmin and MMP systems after vascular injury in mice with targeted inactivation of fibrinolytic genes Arterioscler. Thromb. Vasc. Biol. 18 1998 1035
15. S.M. Nicholl, E. Roztocil, M.G. Davies Urokinase (uPA) induced smooth muscle cell responses require distinct signaling pathways A role for the epidermal growth factor receptor J. Vasc. Surg. 2005 (in press)
16. H. Wang, J.J. Ubl, R. Stricker, G. Reiser Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways Am. J. Physiol. (Cell Physiol.) 283 2002 C1351
17. B.E. Hawes, T. vanBiesen, W.J. Koch, L.M. Luttrell, R.J. Lefkowitz Distinct pathways of Gβγ-mediated activation of mitogen activated protein kinase and phosphoinositid hydrolysis J. Biol. Chem. 270 1995 17148
18. J. Trejo Protease-activated receptors New concepts in regulation of G-protein-coupled receptor signaling and trafficking J. Pharmacol. Expt. Ther. 307 2003 437
19. R. Goel, P.J. Phillips-Mason, A. Gardner, D.M. Raben, J.J. Baldassare α-thrombin-mediated PI3K activation through release of Gβγ dimers from Gαq and Gαi2 J. Biol. Chem. 279 2004 6701