Classical conditioning of endocrine effects

Current Opinion in Psychiatry

Volumn 18, Issue 2, 2005, Pages 181-187

  Stockhorst, Ursula ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Central nervous system; Classical conditioning; Gender; Hormones

Indexed keywords

CORTICOSTERONE; GLUCOCORTICOID; GLUCOSE; INSULIN; NEUROTRANSMITTER; SEX HORMONE;

ADAPTATION; CORTICOSTERONE RELEASE; ENDOCRINE SYSTEM; GENDER; GLUCOSE BLOOD LEVEL; HORMONE RESPONSE; HUMAN; INSULIN SYNTHESIS; MEDIATOR RELEASE; NONHUMAN; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STATE DEPENDENT LEARNING; STIMULUS;

EID: 20444448017     PISSN: 09517367     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001504-200503000-00012     Document Type: Review

References (32)

1. Dworkin BR. Learning and physiological regulation. Chicago: The University of Chicago Press; 1993.
2. Ramsay DS, Woods SC. Biological consequences of drug administration: implications for acute and chronic tolerance. Psychol Rev 1997; 104:170-193.
3. Woods SC, Ramsay DS. Pavlovian influences over food and drug intake. Behav Brain Res 2000; 110:175-182.
4. Stockhorst U, Steingrüber HJ, Scherbaum WA. Classically conditioned responses following repeated insulin and glucose administration in humans. Behav Brain Res 2000; 110:143-159.
5. Stockhorst U, Mahl N, Krueger M, et al. Classical conditioning and condition-ability of insulin and glucose effects in healthy humans. Physiol Behav 2004; 81:375-388. A conditioning protocol was implemented in humans: they learned an association between an arbitrary conditioned stimulus and the injection of insulin, glucose or placebo (independent groups). Serum insulin, blood glucose and a broad spectrum of glucoregulatory hormones and symptoms were measured during acquisition as well as test (conditioned responses). Detailed discussion on the mediation of the conditioning effects (e.g. by referring to insulin detection in the brain) is given.
6. Woods SC, Burchfield SR. Conditioned endocrine responses. In: Ferguson J, Taylor B, editors. The comprehensive handbook of behavioral medicine, Vol.1. Lancaster: MTP Press; 1980. pp.239-254.
7. Stanton ME, Levine S. Pavlovian conditioning of endocrine responses. In: Weiner H, Ader R, editors. Experimental foundations of behavioral medicine: conditioning approaches. Hillsdale, NJ: Academic Press; 1988. pp. 25-46.
8. Arosio M, Ronchi CL, Beck-Peccoz P, et al. Effects of modified sham feeding on ghrelin levels in healthy human subjects. J Clin Endocrinol Metab 2004; 89:5101-5104. This article provides first evidence for a cephalic response of ghrelin by demonstrating its release and suppression by a sham-feeding situation in humans. The cephalic response corresponded to the vagally mediated ghrelin response under real-feeding conditions. Measuring ghrelin responses after association of an arbitrary conditioned stimulus previously paired with food would be the indicator of a true conditioning etiology of that response.
9. Siegel S, Ramos BMC. Applying laboratory research: drug anticipation and the treatment of drug addiction. Psychopharmacol 2002; 10:162-183.
10. Hill MN, Gorzalka BB, Choi JW. Augmentation of the development of behavioral tolerance to cannabinoid administration through Pavlovian conditioning. Neuropsychobiology 2004; 49:94-100. This article illustrates the regulatory function of classical conditioning for withdrawal symptoms with psychoactive substances - here, cannabinoids.
11. Benedetti F, Pollo A, Lopiano L, et al. Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses. J Neurosci 2003; 23:4315-4323. Although using a non-optimal design for their study, the authors examine the conditionability of sumatriptan effects in healthy humans, combined with the question of whether the type of instruction (placebo versus nocebo) is relevant.
12. Pfaff DW, Philipps MI, Rubin RT. Principles of hormone/behavior relations. Amsterdam: Elsevier Academic Press; 2004.
13. Graeff FG, Parente A, Del-Ben CM, Guimaraes FS. Pharmacology of human experimental anxiety. Braz J Med Biol Res 2003; 36:421-432. This article reviews the validity of two conditioning paradigms (aversive conditioning using tone-shock pairings and startle response) as tools to examine the etiology and pharmacological treatment of anxiety in healthy humans and patients with anxiety disorders.
14. Hui GK, Figueroa IR, Poytress BS, et al. Memory enhancement of classical fear conditioning by post-training injections of corticosterone in rats. Neurobiol Learn Mem 2004; 81:67-74. This article provides evidence for the enhancing effects of post-training glucocorticoids.
15. Conrad CD, McMillan DD, Tsekhanov S, et al. Influence of chronic corticosterone and glucocorticoid receptor antagonism in the amygdala on fear conditioning. Neurobiol Learn Mem 2004; 81:185-199. This study shows the differential impact of chronic glucocorticoid treatment (21 days) on subsequent enhancement of contextual (more responsive) versus cued (less responsive) fear conditioning.
16. Beylin AV, Shors TJ. Glucocorticoids are necessary for enhancing the acquisition of associative memories after acute stressful experience. Horm Behav 2003; 43:124-131. This article outlines the role of glucocorticoids in enhancing the acquisition of the consequences of acute, but not persistent, stressful experience.
17. Zorawski M, Killcross S. Glucocorticoid receptor agonist enhances Pavlovian appetitive conditioning but disrupts outcome-specific associations. Behav Neurosci 2003; 117:1453-1457. This study describes the differential effect of glucocorticoids on Pavlovian conditioning (facilitation) versus instrumental conditioning (disruption) in male rats.
18. Grillon C, Cordova J, Morgan CA, et al. Effects of the beta-blocker propranolol on cued and contextual fear conditioning in humans. Psychopharmacol 2004; 175:342-352. Using a placebo controlled differential conditioning design in humans, this experimental study shows that beta-adrenergic receptors are involved in contextual, but not cued, fear conditioning. It provides ideas on how conditioning techniques can be used as research tools to select differential pharmacological treatment for specific versus general anxiety disorders.
19. Miranda MI, LaLumiere RT, Buen TV, et al. Blockade of noradrenergic receptors in the basolateral amygdala impairs taste memory. Eur J Neurosci 2003; 18:2605-2610. This article outlines that central noradrenergic blockade impairs recall of taste aversion in male rats.
20. Shors TJ. Learning during stressful times. Learn Mem 2004; 11:137-144. This is a very elegant, informative and clearly written review on the impact of stress on classical and instrumental conditioning, especially addressing gender-specific effects.
21. Bangasser DA, Shors TJ. Acute stress impairs trace eyeblink conditioning in females without altering the unconditioned response. Neurobiol Learn Mem 2004; 82:57-60. This article provides evidence that the impairment of classical conditioning by stressors in female rats is not due to a decreased perception of unconditioned stress strength.
22. Shors TJ, Miesegaes G. Testosterone in utero and at birth dictates how stressful experience will affect learning in adulthood. PNAS 2002; 99: 13955-13960.
23. Young BJ, Cook CJ. Stress-induced modification of anxiety in rats is dependent on reproductive status. Physiol Behav 2004; 80:569-575. This is another support for the modifying effect of gonadal hormones.
24. Sorg BA, Swindell S, Tschirgi ML. Repeated low level formaldehyde exposure produces enhanced fear conditioning to odor in male, but not female, rats. Brain Res 2004; 1008:11-19. This is an interesting study for gender-specific conditioning effects using an odor-aversion conditioning procedure; it discusses clinical implications for multiple chemical sensitivity and the related development of panic-like responses via conditioning.
25. Foy MR, Foy JG. Reversal of long-delay conditioned taste aversion learning in rats by sex hormone manipulation. Integr Physiol Behav Sci 2003; 38:203-213. This is a very elegant experimental study, manipulating sex hormones by surgery (gonadectomy) and hormone replacement in male and female rats, using a conditioned taste aversion paradigm and demonstrating gender effects.
26. Cheng JJ, de Bruin JPC, Feenstra MGP. Dopamine efflux in nucleus accumbens shell and core in response to appetitive classical conditioning. Eur J Neurosci 2003; 18:1306-1314. The response to an appetitive conditioned stimulus (test phase) is shown to be accompanied by a dopamine efflux in both core and shell of the nucleus accumbens.
27. Mingote S, de Bruin JPC, Feenstra MGP. Noradrenaline and dopamine efflux in the prefrontal cortex in relation to appetitive classical conditioning. J Neurosci 2004; 24:2475-2480. This article outlines the role of central noradrenaline and dopamine in appetitive conditioning after a short learning period (2 days' conditioned stimulus-food pairing).
28. Tobler PN, Dickinson A, Schultz W. Coding of predicted reward omission by dopamine neurons in a conditioned inhibition paradigm. J Neurosci 2003; 23:10 402-10 410.
29. Molodtsova GF. Differences in serotonin and dopamine metabolism in the rat brain in latent inhibition. Neurosci Behav Physiol 2003; 33:217-222. This article shows the specific contribution of an increase in serotonergic, not dopamine, metabolism when latent inhibition is acquired.
30. Ader R. Conditioned immunomodulation: research needs and directions. Brain Behav Immun 2003; 17:S51-S57. This is an interesting review, outlining future research questions in psychoneuroimmunology and describing the methodological preconditions for conditioning studies.
31. Chen J, Lin W, Wang W, et al. Enhancement of antibody production and expression of c-Fos in the insular cortex in response to a conditioned stimulus after a single-trial learning paradigm. Behav Brain Res 2004; 154:557-565. This article examines the neural mechanisms relevant to the expression of a conditioned antibody response.
32. Irie M, Nagata S, Endo Y. Diazepam attenuates conditioned histamine release in guinea pigs. Int J Psychophysiol 2004; 51:231-238. This study illustrates how diazepam affects a previously conditioned response of conditioned stimulus-antigen pairings.