Lower cortisol concentrations in patients with liver disease: More adrenal failure or more confusion?

Critical Care Medicine

Volumn 33, Issue 6, 2005, Pages 1431-1432

  Tayek, John A ^a  

^a LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

Adrenal failure; Liver disease; Serum cortisol; Thyroid binding protein

Indexed keywords

CORTICOTROPIN; HORMONE BINDING PROTEIN; HYDROCORTISONE; INTERLEUKIN 6; LEUKOCYTE ELASTASE;

ADRENAL INSUFFICIENCY; CONCENTRATION RESPONSE; EDITORIAL; HORMONE DETERMINATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; LIVER DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SYSTOLIC BLOOD PRESSURE;

ADRENAL INSUFFICIENCY; CARRIER PROTEINS; HUMANS; HYDROCORTISONE; LIVER FAILURE;

EID: 20444445504     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000166680.42475.B7     Document Type: Editorial

References (15)

1. Marik PE, Gayowski T, Starzl TE: The hepatoadrenal syndrome: A common yet unrecognized clinical condition. Crit Care Med 2005; 33:1254-1259
2. Manglik S, Flores E, Lubarsky L, et al: Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: A prospective clinical trial. Crit Care Med 2003; 31:1668-1675
3. McDonald JA, Handelsman DJ, Dilworth P, et al: Hypothalamic-pituitary adrenal function in end-stage non-alcoholic liver disease. J Gastroenterol Hepatol 1993; 8:247-253
4. Doe RP, Fernandez R, Seal US: Measurement of corticosteroid-binding globulin in man. J Clin Endocrinol 1964; 24:1029-1039
5. Hamrahian AH, Oseni TS, Arafah BM: Measurements of serum free cortisol in critically ill patients. N Engl J Med 2004; 350: 1629-1638
6. Perrot D, Bonneton A, Dechaud H, et al: Hypercortisolism in septic shock is not suppressible by dexamethasone infusion. Crit Care Med 1993; 21:396-401
7. Beishuizen A, Thijs LG, Vermes I: Patterns of corticosteroid-binding globulin and the free cortisol index during septic shock and multitrauma. Intensive Care Med 2001; 27:1584-1591
8. Bly B, Roucloux I, Crusisux A, et al: Tumor necrosis factor alpha and interleukin 6 plasma levels in infected cirrhotic patients. Gastroenterology 1993; 104:1492-1497
9. Bartalena L, Hammond GL, Farsetti A, et al: Interleukin-6 inhibits corticosteroid-binding globulin synthesis by human hepatoblastoma-derived (Hep G2) cells. Endocrinol 133:291-296
10. Emptoz-Bonneton A, Cousin P, Seguchi K, et al: Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity. J Clin Endocrinol Met 2000; 85:361-367
11. Bernier J, Jobin N, Emptoz-Bonneton A, et al: Decreased corticosteroid-binding globulin in burn patients: Relationship with interleukin-6 and fat in nutritional support. Crit Care Med 1998; 26:452-460
12. Vogeser M, Groetzner J, Kupper C, et al: Free serum cortisol during the postoperative acute phase response determined by equilibrium dialysis liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med 2003; 41:146-151
13. Tayek JA, Atienza VJ: Pituitary-adrenal axis function in systemic inflammatory response syndrome. Endocrine 1995; 3:315-318
14. Annane D, Sebille V, Charpentier C, et al: Effect of treatment with low dose of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288:862-871
15. Moran JL, Chapman MJ, O'Fathartaigh MS, et al: Hypocortisolaemia and adrenocortical responsiveness at onset of septic shock. Intensive Care Med 1994; 20:489-495