Combined effects of protein kinase inhibitors and 5-fluorouracil on CEA expression in human colon cancer cells

Pharmacological Research

Volumn 52, Issue 2, 2005, Pages 167-173

  Prete, Salvatore Pasquale ^a   Rossi, Lorena ^a   Correale, Pier Paolo ^b   Turriziani, Mario ^a   Baier, Susanne ^a   Tamburrelli, Giuliana ^a   De Vecchis, Liana ^a   Bonmassar, Enzo ^a   Aquino, Angelo ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

5 Fluorouracil; CEA; Colon carcinoma; Immunotherapy; Staurosporine

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; BISINDOLYLMALEIMIDE; CARCINOEMBRYONIC ANTIGEN; FLUOROURACIL; GENISTEIN; HERBIMYCIN A; STAUROSPORINE;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; WESTERN BLOTTING;

CARCINOEMBRYONIC ANTIGEN; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FLUOROURACIL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; PROTEIN KINASE INHIBITORS; STAUROSPORINE;

EID: 20444437098     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phrs.2004.12.007     Document Type: Article

References (38)

1. J.W. Greiner, F. Guadagni, P. Noguchi, S. Pestka, D. Colcher, and P.B. Fisher Recombinant interferon enhances monoclonal antibody-targeting of carcinoma lesions in vivo Science 235 1987 895 898
2. 131I-CC49) when given in combination with gamma-interferon Cancer Res 53 1993 600 608
3. F. Guadagni, M. Roselli, J. Schlom, and J.W. Greiner In vitro and in vivo regulation of human tumor antigen expression by human recombinant interferons: a review Int J Biol Markers 9 1994 53 60
4. R.M. Conry, A.F. LoBuglio, J. Kantor, J. Schlom, F. Loechel, and S.E. Moore Immune response to a carcinoembryonic antigen polynucleotide vaccine Cancer Res 54 1994 1164 1168
5. K.Y. Tsang, S. Zaremba, C.A. Nieroda, M.Z. Zhu, J.M. Hamilton, and J. Schlom Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine J Natl Cancer Inst 87 1995 982 990
6. J.W. Hodge Carcinoembryonic antigen as a target for cancer vaccines Cancer Immunol Immunother 43 1996 127 134
7. D.J. Cole, M.C. Wilson, P.L. Baron, P. O'Brien, C. Reed, and K.Y. Tsang Phase I study of recombinant CEA vaccinia virus vaccine with post vaccination CEA peptide challenge Hum Gene Ther 7 1996 1381 1394
8. K.A. Foon, J.W. John, M. Chakraborty, A. Sherratt, J. Garrison, and M. Flett Clinical and immune responses in advanced colorectal cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen Clin Cancer Res 3 1997 1267 1276
9. M. Gerhard, H. Juhl, H. Kalthoff, H.W. Schreiber, C. Wagener, and M. Neumaier Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction J Clin Oncol 12 1994 725 729
10. M. Mori, K. Mimori, H. Ueo, N. Karimine, F. Barnard, and K. Sugimachi Molecular detection of circulating solid carcinoma cells in the peripheral blood: the concept of early systemic disease Int J Cancer 68 1996 739 743
11. Y. Ko, M. Klinz, G. Totzke, I. Gouni-Berthold, A. Sachinidis, and H. Vetter Limitation of the reverse transcription-polymerase chain reaction method for the detection of carcinoembryonic antigen-positive tumor cells in peripheral blood Clin Cancer Res 4 1998 2141 2146
12. G.J. Liefers, A.M. Cleton-Jansen, C.J. van de Velde, J. Hermans, J.H. van Krieken, and C.J. Cornelisse Micrometastases and survival in stage II colorectal cancer N Engl J Med 339 1998 223 238
13. J.W. Greiner, J. Schlom, S. Pestka, J.A. Langer, P. Giacomini, and M. Kusama Modulation of tumor associated antigen expression and shedding by recombinant human leukocyte and fibroblast interferons Pharmacol Ther 31 1985 209 236
14. C. Dansky-Ullmann, M. Salgaller, S. Adams, J. Schlom, and J.W. Greiner Synergistic effects of IL-6 and IFN-gamma on carcinoembryonic antigen (CEA) and HLA expression by human colorectal carcinoma cells: role for endogenous IFN-beta Cytokine 7 1995 118 129
15. I.W. Maas, E. Boven, H.M. Pinedo, H.M. Schluper, and H.J. Haisma The effects of gamma-interferon combined with 5-fluorouracil or 5-fluoro-2′- deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines Int J Cancer 48 1991 749 756
16. R. De Filippi, S.P. Prete, A. Giuliani, E. Silvi, H. Yamaue, and C.A. Nieroda Differential effects of recombinant interferon-alpha and 5-fluorouracil against colon cancer cells or against peripheral blood mononuclear cells Anticancer Res 14 1994 1767 1773
17. S.P. Prete, A. Aquino, G. Masci, L. Orlando, A. Giuliani, and S. De Santis Drug-induced changes of carcinoembryonic antigen expression in human cancer cell: effect of 5-fluorouracil J Pharmacol Exp Ther 279 1996 1574 1581
18. A. Aquino, S.P. Prete, J.W. Greiner, A. Giuliani, G. Graziani, and M. Turriziani Effect of the combined treatment with 5-fluorouracil, gamma-interferon or folinic acid on carcinoembryonic antigen expression in colon cancer cells Clin Cancer Res 4 1998 2473 2481
19. ++ dependent protein kinase Biochem Biophys Res Commun 135 1986 397 402
20. S. Yamada, K. Hirota, K. Chida, and T. Kuroki Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C Biochem Biophis Res Commun 157 1988 9 15
21. A. Aquino, S.P. Prete, S. Baier, D. Cappelletti, J.W. Greiner, and L. De Vecchis Staurosporine increases carcinoembryonic antigen expression in a human colon cancer cell line J Chemother 12 2000 167 172
22. S.P. Prete, D. Cappelletti, S. Baier, P. Nasuti, F. Guadagni, and L. De Vecchis Pharmacological modulation of carcinoembryonic antigen in human cancer cells: studies with staurosporine Int Immunopharmacol 2 2002 641 651
23. R. Muraro, D. Wunderlich, A. Thor, J. Lundy, P. Noguchi, and R. Cunningham Definition by monoclonal antibodies of a repertoire of epitopes on carcinoembryonic antigen differentially expressed in human colon carcinomas versus normal adult tissues Cancer Res 45 1985 5769 5780
24. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 6855
25. H. Towbin, T. Staehelin, and J. Gordon Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: procedure and some applications Proc Natl Acad Sci USA 76 1979 4350 4354
26. A. Aquino, V. Formica, S.P. Prete, P.P. Correale, M.C. Massara, and M. Turriziani Drug-induced increase of carcinoembryonic antigen expression in cancer cells Pharmacol Res 49 2004 383 396
27. C. Courage, J. Budworth, and A. Gescher Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation Br J Cancer 71 1995 697 704
28. S. Chakrabarty, J.W. Chen, X.Y. Chen, J.M. Trujillo, and P.F. Lin Modulation of differentiation-related responses in human colon carcinoma cells by protein kinase inhibitor H-7 Anticancer Res 12 1992 97 104
29. M. Yoshimura, A. Nishikawa, T. Nishiura, Y. Ihara, Y. Kanayama, and Y. Matsuzawa Cell spreading in colon 201 by staurosporin is alpha 3 beta 1 integrin-mediated with tyrosine phosphorylation of src and tensin J Biol Chem 270 1995 2298 2304
30. C. Ventura, and M. Maioli Protein kinase C control of gene expression Crit Rev Eukaryot Gene Expr 11 2001 243 267
31. J. Hofmann Protein kinase C isozymes as potential targets for anticancer therapy Curr Cancer Drug Targets 4 2004 125 146
32. J.P. Secrist, I. Sehgal, G. Powis, and R.T. Abraham Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine J Biol Chem 265 1990 20394 20400
33. L. Qiao, M. Koutsos, L.L. Tsai, V. Kozoni, J. Guzman, and S.J. Shiff Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells Cancer Lett 107 1996 83 89
34. H.J. Chae, J.S. Kang, J.O. Byun, K.S. Han, D.U. Kim, and S.M. Oh Molecular mechanism of staurosporine-induced apoptosis in osteoblasts Pharmacol Res 42 2000 373 381
35. T. Jones, C. Courage, A. Hubbard, and A. Gescher Cellular relocalisation of protein kinase C-theta caused by staurosporine and some of its analogues Biochem Pharmacol 53 1997 1413 1418
36. M.M. Facchinetti, A. De Siervi, and D. Toskos Senderowicz AM. UCN-01-induced cell cycle arrest requires the transcriptional induction of p21 (waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway Cancer Res 64 2004 3629 3637
37. P. Correale, A. Aquino, A. Giuliani, M. Pellegrini, L. Micheli, and M.G. Cusi Treatment of colon and breast carcinoma cells with 5-fluorouracil enhances expression of carcinoembryonic antigen and susceptibility to HLA-A(*)02.01 restricted, CEA-peptide-specific cytotoxic T cells in vitro Int J Cancer 104 2003 437 445
38. A. Aquino, S.P. Prete, A. Balduzzi, V. Formica, E. Fossile, and L. Bonmassar Treatment of peripheral blood with staurosporine increases detection of circulating carcinoembryonic antigen positive tumor cells Int J Cancer 100 2002 119 121