A novel and selective endothelin ETA receptor antagonist YM598 prevents the development of chronic hypoxia-induced pulmonary hypertension in rats

Vascular Pharmacology

Volumn 43, Issue 1, 2005, Pages 40-46

  Yuyama, Hironori ^a   Fujimori, Akira ^a   Sanagi, Masanao ^a   Koakutsu, Akiko ^a   Noguchi, Yukiko ^a   Sudoh, Katsumi ^a   Sasamata, Masao ^a   Miyata, Keiji ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Chronic hypoxia; Endothelin; Pulmonary hypertension; Selective endothelin ETA receptor antagonist

Indexed keywords

ENDOTHELIN A RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; YM 598;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL GAS; ARTICLE; CARDIOPULMONARY HEMODYNAMICS; CONTROLLED STUDY; DIASTOLE; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXEMIA; HYPOXIA; LUNG ARTERY PRESSURE; LUNG CONGESTION; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT;

ANIMALS; ANOXIA; BLOOD GAS ANALYSIS; CHRONIC DISEASE; DISEASE PROGRESSION; HEMODYNAMIC PROCESSES; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; MALE; PULMONARY EDEMA; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN A; SULFONAMIDES;

EID: 20444435558     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2005.03.001     Document Type: Article

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