Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12

Atherosclerosis

Volumn 181, Issue 1, 2005, Pages 131-135

  Till, Uwe ^a   Röhl, Peter ^b   Jentsch, Almut ^a   Till, Heiko ^a   Müller, Andreas ^a   Bellstedt, Klaus ^a   Plonné, Dietmar ^a   Fink, Horst S ^a   Vollandt, Rüdiger ^a   Sliwka, Ulrich ^c   Herrmann, Falko H ^d   Petermann, Henning ^a   Riezler, Reiner ^e  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b Catholic Hospital   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d UNIVERSITY OF GREIFSWALD   (Germany)

^e Severimed   (Germany)

Author keywords

Atherosclerosis; Cerebral ischemia; Homocysteine; Intima media thickness; Vitamin supplementation

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PLACEBO; PYRIDOXINE;

ADULT; AGED; ARTERY WALL; ARTICLE; BRAIN ATHEROSCLEROSIS; BRAIN ISCHEMIA; CARDIOVASCULAR RISK; CAROTID ARTERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE MARKER; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; INTIMA; MALE; MULTICENTER STUDY; MULTIPLE REGRESSION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; THICKNESS; TUNICA MEDIA; VITAMIN SUPPLEMENTATION;

AGED; BRAIN ISCHEMIA; CAROTID ARTERIES; DOUBLE-BLIND METHOD; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; INTRACRANIAL ARTERIOSCLEROSIS; MALE; MIDDLE AGED; RISK FACTORS; TUNICA INTIMA; TUNICA MEDIA; VITAMIN B 12; VITAMIN B 6;

EID: 20444428707     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2004.12.043     Document Type: Article

References (27)

1. I.M. Graham, L.E. Daly, and H.M. Refsum Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project JAMA 277 22 1997 1775 1781
2. M. den Heijer, I.A. Brouwer, and G.M. Bos Vitamin supplementation reduces blood homocysteine levels: a controlled trial in patients with venous thrombosis and healthy volunteers Arterioscler. Thromb. Vasc. Biol. 18 3 1998 356 361
3. J.F. Toole, M.R. Malinow, and L.E. Chambless Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the vitamin intervention for stroke prevention (VISP) randomized controlled trial JAMA 291 5 2004 565 575
4. A. Poli, E. Tremoli, A. Colombo, M. Sirtori, P. Pignoli, and R. Paoletti Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients. A new model for the quantitation and follow-up of preclinical atherosclerosis in living human subjects Atherosclerosis 70 3 1988 253 261
5. P. Greenland, J. Abrams, and G.P. Aurigemma Prevention conference V. Beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III Circulation 101 1 2000 E16 E22
6. D.H. O'Leary, J.F. Polak, R.A. Kronmal, T.A. Manolio, G.L. Burke, and S.K. Wolfson Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular health study collaborative research group N. Engl. J. Med. 340 1 1999 14 22
7. M.R. Malinow, F.J. Nieto, M. Szklo, L.E. Chambless, and G. Bond Carotid arterey intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults Circulation 87 1993 1107 1113
8. B.M. McQuillan, J.P. Beilby, M. Nidorf, P.L. Thompson, and J. Hung Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The perth carotid ultrasound disease assessment study (CUDAS) Circulation 99 18 1999 2383 2388
9. A. Tawakol, T. Omland, M. Gerhard, J.T. Wu, and M.A. Creager Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans Circulation 95 5 1997 1119 1121
10. M. Hashimoto, M. Eto, and M. Akishita Correlation between flow-mediated vasodilatation of the brachial artery and intima-media thickness in the carotid artery in men Arterioscler. Thromb. Vasc. Biol. 19 11 1999 2795 2800
11. H.N. Hodis, W.J. Mack, and L. LaBree Reduction in carotid arterial wall thickness using lovastatin and dietary therapy: a randomized controlled clinical trial Ann. Intern. Med. 124 6 1996 548 556
12. A. Simon, J. Gariepy, D. Moyse, and J. Levenson Differential effects of nifedipine and co-amilozide on the progression of early carotid wall changes Circulation 103 24 2001 2949 2954
13. S.P. Stabler, J. Lindenbaum, D.G. Savage, and R.H. Allen Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency Blood 81 12 1993 3404 3413
14. R.H. Allen, S.P. Stabler, and J. Lindenbaum Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism Metabolism 42 11 1993 1448 1460
15. P. Frosst, H.J. Blom, and R. Milos A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nature Genet. 10 1 1995 111 113
16. M.R. Malinow, A.G. Bostom, and R.M. Krauss Homocyst(e)ine, diet, and cardiovascular diseases: a statement for healthcare professionals from the Nutrition Committee American Heart Association Circulation 99 1 1999 178 182
17. G. Belcaro, A.N. Nicolaides, and G. Laurora Ultrasound morphology classification of the arterial wall and cardiovascular events in a 6-year follow-up study Arterioscler. Thromb. Vasc. Biol. 16 7 1996 851 856
18. O. Nygard, S.E. Vollset, and H. Refsum Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study JAMA 274 19 1995 1526 1533
19. J.C. Peterson, and J.D. Spence Vitamins and progression of atherosclerosis in hyper-homocyst(e)inaemia Lancet 351 9098 1998 263
20. E.G. Vermeulen, C.D. Stehouwer, and J.W. Twisk Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial Lancet 355 9203 2000 517 522
21. R. Marcucci, M. Zanazzi, and E. Bertoni Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipients Transplantation 75 9 2003 1551 1555
22. C.J. Bates, M.A. Mansoor, J. Gregory, K. Pentiev, and A. Prentice Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of young people aged 4-18 years, and a comparison with the survey of people aged 65 years and over Br. J. Nutr. 87 1 2002 71 79
23. W.E. Skiba, M.P. Taylor, M.S. Wells, J.H. Mangum, and W.M. Awad Jr. Human hepatic methionine biosynthesis. Purification and characterization of betaine: homocysteine S-methyltransferase J. Biol. Chem. 257 24 1982 14944 14948
24. D.G. Hackam, J.C. Peterson, and J.D. Spence What levels of plasma homocyst(e)ine should be treated? Effects of vitamin therapy on progression of carotid atherosclerosis in patients with homocyst(e)ine levels above and below 14 μmol/L Am. J. Hypertens. (Part 1) 13 2000 105 110 (1 Pt 1):
25. S.J. Moat, Z.L. Clarke, M.J. Lewis, and D. Lang Folic acid reverses endothelial dysfunction: an effect independent of tetrahydrobiopterin regeneration J. Inherit. Metab. Dis. 26 Suppl 1 2003 77
26. S.N. Doshi, I.F. McDowell, and S.J. Moat Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering Circulation 105 1 2002 22 26
27. A. Liem, G.H. Reynierse-Buitenwerf, A.H. Zwinderman, J.W. Jukema, and D.J. van Veldhuisen Secondary prevention with folic acid: effect on clinical outcomes J. Am. Coll. Cardiol. 41 12 2003 2105 2113