Oxidation and biotinylation of beta 2 glycoprotein I glycan chains induce an increase in its affinity for anionic phospholipids similar to that obtained by the addition of anti-beta 2 glycoprotein I or anti-cardiolipin antibodies

Journal of Immunological Methods

Volumn 300, Issue 1-2, 2005, Pages 160-178

  D'Angeac, Arnaud Dupuy ^a   Stefas, Ilias ^b   Duperray, Christophe ^c   Rucheton, Marcel ^b   Graafland, Hubert ^d   Montero, Jean Louis ^a   Chicheportiche, Robert ^a  

^a CNRS   (France)

^b INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^c INSERM   (France)

^d MONTPELLIER UNIVERSITY HOSPITAL   (France)

Author keywords

Anionic phospholipids; Apoptosis; Beta 2 glycoprotein I; Biotin; Confocal microscopy; Cytometry; Equilibrium binding

Indexed keywords

BETA2 GLYCOPROTEIN 1; BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; FLUORESCEIN ISOTHIOCYANATE; GLYCAN DERIVATIVE; HYDRAZIDE DERIVATIVE; LIPOCORTIN 5; MONOCLONAL ANTIBODY; PHOSPHOLIPID DERIVATIVE;

ANTIBODY AFFINITY; APOPTOSIS; ARTICLE; BIOTINYLATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; OXIDATION; PRIORITY JOURNAL; SOLID STATE;

ANIMALS; ANTIBODIES, ANTICARDIOLIPIN; ANTIBODIES, MONOCLONAL; APOPTOSIS; BETA 2-GLYCOPROTEIN I; BINDING SITES; BIOTINYLATION; CELL LINE; GLYCOPROTEINS; HUMANS; KINETICS; OXIDATION-REDUCTION; PHOSPHOLIPIDS; POLYSACCHARIDES; RECOMBINANT PROTEINS;

EID: 20444420860     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2005.03.016     Document Type: Article

References (58)

1. M.E. Allison, and D.T. Fearon Enhanced immunogenicity of aldehyde-bearing antigens: a possible link between innate and adaptive immunity Eur. J. Immunol. 2000 2881 (Oct.)
2. J. Arnout, C. Wittevrongel, M. Vanrusselt, M. Hoylaerts, and J. Vermylen Beta-2-glycoprotein I dependent lupus anticoagulants form stable bivalent antibody beta-2-glycoprotein I complexes on phospholipid surfaces Thromb. Haemost. 79 1998 79
3. K. Balasubramanian, J. Chandra, and A.J. Schroit Immune clearance of phosphatidylserine-expressing cells by phagocytes. The role of beta2-glycoprotein I in macrophage recognition J. Biol. Chem. 272 1997 31113
4. E.M. Bevers, P. Comfurius, and R.F. Zwaal Changes in membrane phospholipid distribution during platelet activation Biochim. Biophys. Acta 736 1983 57
5. P. Bork, A.K. Downing, B. Kieffer, and I.D. Campbell Structure and distribution of modules in extracellular proteins Q. Rev. Biophys. 29 1996 119
6. B. Bouma, P.G. de Groot, J.M. van den Elsen, R.B. Ravelli, A. Schouten, M.J. Simmelink, R.H. Derksen, J. Kroon, and P. Gros Adhesion mechanism of human beta(2)-glycoprotein I to phospholipids based on its crystal structure EMBO J. 18 1999 5166
7. T.A. Brighton, Y.P. Dai, P.J. Hogg, and C.N. Chesterman Microheterogeneity of beta-2 glycoprotein I: implications for binding to anionic phospholipids Biochem. J. 340 1999 59
8. L.W. Chamley, A.M. Duncalf, B. Konarkowska, M.D. Mitchell, and P.M. Johnson Conformationally altered beta 2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies Clin. Exp. Immunol. 115 1999 571
9. A. Chonn, S.C. Semple, and P.R. Cullis Beta 2 glycoprotein I is a major protein associated with very rapidly cleared liposomes in vivo, suggesting a significant role in the immune clearance of and quot; non-self and quot; particles J. Biol. Chem. 270 1995 25845
10. B.A. Cocca, S.N. Seal, P. D'Agnillo, Y.M. Mueller, P.D. Katsikis, J. Rauch, M. Weigert, and M.Z. Radic Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells Proc. Natl. Acad. Sci. U. S. A. 98 2001 13826
11. V.A. Fadok, D.R. Voelker, P.A. Campbell, J.J. Cohen, D.L. Bratton, and P.M. Henson Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages J. Immunol. 148 1992 2207
12. M. Galazka, M. Tang, V.A. DeBari, J.D. Kohles, J.K. Lee, L.B. Keil, and M. Petersheim Modification of beta 2glycoprotein I by glutardialdehyde. Conformational changes and aggregation accompany exposure of the cryptic autoepitope Appl. Biochem. Biotechnol. 76 1999 1
13. J. George, B. Gilburd, M. Hojnik, Y. Levy, P. Langevitz, E. Matsuura, T. Koike, and Y. Shoenfeld Target recognition of beta2-glycoprotein I (beta2GPI)-dependent anticardiolipin antibodies: evidence for involvement of the fourth domain of beta2GPI in antibody binding J. Immunol. 160 1998 3917
14. M. Hammel, R. Schwarzenbacher, A. Gries, G.M. Kostner, P. Laggner, and R. Prassl Mechanism of the interaction of beta(2)-glycoprotein I with negatively charged phospholipid membranes Biochemistry 40 2001 14173
15. M. Hammel, M. Kriechbaum, A. Gries, G.M. Kostner, P. Laggner, and R. Prassl Solution structure of human and bovine beta(2)-glycoprotein I revealed by small-angle X-ray scattering J. Mol. Biol. 321 2002 85
16. Y. Hashimoto, M. Kawamura, K. Ichikawa, T. Suzuki, T. Sumida, S. Yoshida, E. Matsuura, S. Ikehara, and T. Koike Anticardiolipin antibodies in NZW × BXSB F1 mice. A model of antiphospholipid syndrome J. Immunol. 149 1992 1063
17. R. Haugland Handbook of Fluorescent Probes and Research Chemicals 1992 Molecular Probes, Inc. Eugene, OR
18. M. Hoshino, Y. Hagihara, I. Nishii, T. Yamazaki, H. Kato, and Y. Goto Identification of the phospholipid-binding site of human beta(2)-glycoprotein I domain V by heteronuclear magnetic resonance J. Mol. Biol. 304 2000 927
19. J. Hunt, and S. Krilis The fifth domain of beta 2-glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anticardiolipin antibodies J. Immunol. 152 1994 653
20. J.E. Hunt, R.J. Simpson, and S.A. Krilis Identification of a region of beta 2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity Proc. Natl. Acad. Sci. U. S. A. 90 1993 2141
21. K. Ichikawa, M.A. Khamashta, T. Koike, E. Matsuura, and G.R. Hughes Beta 2-glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome Arthritis Rheum. 37 1994 1453
22. M. Igarashi, E. Matsuura, Y. Igarashi, H. Nagae, K. Ichikawa, D.A. Triplett, and T. Koike Human beta2-glycoprotein I as an anticardiolipin cofactor determined using mutants expressed by a baculovirus system Blood 87 1996 3262
23. G.M. Iverson, E.J. Victoria, and D.M. Marquis Anti-beta2 glycoprotein I (beta2GPI) autoantibodies recognize an epitope on the first domain of beta2GPI Proc. Natl. Acad. Sci. U. S. A. 95 1998 15542
24. Z. Kertesz, B.B. Yu, A. Steinkasserer, H. Haupt, A. Benham, and R.B. Sim Characterization of binding of human beta 2-glycoprotein I to cardiolipin Biochem. J. 310 1995 315
25. T. Kristensen, I. Schousboe, E. Boel, E.M. Mulvihill, R.R. Hansen, K.B. Moller, N.P. Moller, and L. Sottrup-Jensen Molecular cloning and mammalian expression of human beta 2-glycoprotein I cDNA FEBS Lett. 289 1991 183
26. J.S. Levine, R. Subang, J.S. Koh, and J. Rauch Induction of anti-phospholipid autoantibodies by beta2-glycoprotein I bound to apoptotic thymocytes J. Autoimmun. 11 1998 413
27. J.S. Levine, J.S. Koh, R. Subang, and J. Rauch Apoptotic cells as immunogen and antigen in the antiphospholipid syndrome Exp. Mol. Pathol. 66 1999 82
28. Q. Liu, K. Kobayashi, J. Furukawa, J. Inagaki, N. Sakairi, A. Iwado, T. Yasuda, T. Koike, D.R. Voelker, and E. Matsuura Omega-carboxyl variants of 7-ketocholesteryl esters are ligands for beta(2)-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages J. Lipid Res. 43 2002 1486
29. J. Lozier, N. Takahashi, and F.W. Putnam Complete amino acid sequence of human plasma beta 2-glycoprotein I Proc. Natl. Acad. Sci. U. S. A. 81 1984 3640
30. B.C. Lutters, J.C. Meijers, R.H. Derksen, J. Arnout, and P.G. de Groot Dimers of beta 2-glycoprotein I mimic the in vitro effects of beta 2-glycoprotein I-anti-beta 2-glycoprotein I antibody complexes J. Biol. Chem. 276 2001 3060
31. H. Mehdi, M.J. Kaplan, F.Y. Anlar, X. Yang, R. Bayer, K. Sutherland, and M.E. Peeples Hepatitis B virus surface antigen binds to apolipoprotein H J. Virol. 68 1994 2415
32. H. Mehdi, X. Yang, and M.E. Peeples An altered form of apolipoprotein H binds hepatitis B virus surface antigen most efficiently Virology 217 1996 58
33. H. Mehdi, A. Naqvi, and M.I. Kamboh A hydrophobic sequence at position 313-316 (Leu-Ala-Phe-Trp) in the fifth domain of apolipoprotein H (beta2-glycoprotein I) is crucial for cardiolipin binding Eur. J. Biochem. 267 2000 1770
34. D. Mevorach Opsonization of apoptotic cells. Implications for uptake and autoimmunity Ann. N.Y. Acad. Sci. 926 2000 226
35. J. Nimpf, E.M. Bevers, P.H. Bomans, U. Till, H. Wurm, G.M. Kostner, and R.F. Zwaal Prothrombinase activity of human platelets is inhibited by beta 2-glycoprotein-I Biochim. Biophys. Acta 884 1986 142
36. V. Pengo, A. Biasiolo, and M.G. Fior Autoimmune antiphospholipid antibodies are directed against a cryptic epitope expressed when beta 2-glycoprotein I is bound to a suitable surface Thromb. Haemost. 73 1995 29
37. V. Pittoni, and G. Valesini The clearance of apoptotic cells: implications for autoimmunity Autoimmun. Rev. 1 2002 154
38. V. Pittoni, C.T. Ravirajan, S. Donohoe, S.J. MacHin, P.M. Lydyard, and D.A. Isenberg Human monoclonal anti-phospholipid antibodies selectively bind to membrane phospholipid and beta2-glycoprotein I (beta2-GPI) on apoptotic cells Clin. Exp. Immunol. 119 2000 533
39. V. Regnault, J. Arvieux, L. Vallar, and T. Lecompte Both kinetic data and epitope mapping provide clues for understanding the anti-coagulant effect of five murine monoclonal antibodies to human beta2-glycoprotein I Immunology 97 1999 400
40. R. Rojkjaer, D.A. Klaerke, and I. Schousboe Characterization of the interaction between beta2-glycoprotein I and calmodulin, and identification of a binding sequence in beta2-glycoprotein I Biochim. Biophys. Acta 1339 1997 217
41. P. Rovere, A.A. Manfredi, C. Vallinoto, V.S. Zimmermann, U. Fascio, G. Balestrieri, P. Ricciardi-Castagnoli, C. Rugarli, A. Tincani, and M.G. Sabbadini Dendritic cells preferentially internalize apoptotic cells opsonized by anti-beta2-glycoprotein I antibodies J. Autoimmun. 11 1998 403
42. P. Rovere, M.G. Sabbadini, C. Vallinoto, U. Fascio, M. Recigno, M. Crosti, P. Ricciardi-Castagnoli, G. Balestrieri, A. Tincani, and A.A. Manfredi Dendritic cell presentation of antigens from apoptotic cells in a proinflammatory context: role of opsonizing anti-beta2-glycoprotein I antibodies Arthritis Rheum. 42 1999 1412
43. I. Schousboe Binding of beta 2-glycoprotein I to platelets: effect of adenylate cyclase activity Thromb. Res. 19 1980 225
44. I. Schousboe Characterization of the interaction between beta 2-glycoprotein I and mitochondria, platelets, liposomes and bile acids Int. J. Biochem. 15 1983 1393
45. I. Schousboe Beta 2-glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway Blood 66 1985 1086
46. I. Schousboe The inositol-phospholipid-accelerated activation of prekallikrein by activated factor XII at physiological ionic strength requires zinc ions and high-Mr kininogen Eur. J. Biochem. 193 1990 495
47. Y. Sheng, D.A. Kandiah, and S.A. Krilis Anti-beta 2-glycoprotein I autoantibodies from patients with the and quot;antiphospholipid and quot; syndrome bind to beta 2-glycoprotein I with low affinity: dimerization of beta 2-glycoprotein I induces a significant increase in anti-beta 2-glycoprotein I antibody affinity J. Immunol. 161 1998 2038
48. W. Shi, B.H. Chong, and C.N. Chesterman Beta 2-glycoprotein I is a requirement for anticardiolipin antibodies binding to activated platelets: differences with lupus anticoagulants Blood 81 1993 1255
49. I. Stefas, M. Rucheton, A.D. D'Angeac, C. Morel-Baccard, J.M. Seigneurin, J.P. Zarski, M. Martin, M. Cerutti, J.P. Bossy, D. Misse, H. Graafland, and F. Veas Hepatitis B virus Dane particles bind to human plasma apolipoprotein H Hepatology 33 2001 207
50. A. Steinkasserer, C. Estaller, E.H. Weiss, R.B. Sim, and A.J. Day Complete nucleotide and deduced amino acid sequence of human beta 2-glycoprotein I Biochem. J. 277 1991 387
51. A. Steinkasserer, P.N. Barlow, A.C. Willis, Z. Kertesz, I.D. Campbell, R.B. Sim, and D.G. Norman Activity, disulphide mapping and structural modelling of the fifth domain of human beta 2-glycoprotein I FEBS Lett. 313 1992 193
52. R. Subang, J.S. Levine, A.S. Janoff, S.M. Davidson, T.F. Taraschi, T. Koike, S.R. Minchey, M. Whiteside, M. Tannenbaum, and J. Rauch Phospholipid-bound beta 2-glycoprotein I induces the production of anti-phospholipid antibodies J. Autoimmun. 15 2000 21
53. H. Takeya, T. Mori, E.C. Gabazza, K. Kuroda, H. Deguchi, E. Matsuura, K. Ichikawa, T. Koike, and K. Suzuki Anti-beta2-glycoprotein I (beta2GPI) monoclonal antibodies with lupus anticoagulant-like activity enhance the beta2GPI binding to phospholipids J. Clin. Invest. 99 1997 2260
54. I. Vermes, C. Haanen, H. Steffens-Nakken, and C. Reutelingsperger A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V J. Immunol. Methods 184 1995 39
55. S.X. Wang, Y.T. Sun, and S.F. Sui Membrane-induced conformational change in human apolipoprotein H Biochem. J. 348 Pt 1 2000 103
56. G.M. Willems, M.P. Janssen, M.M. Pelsers, P. Comfurius, M. Galli, R.F. Zwaal, and E.M. Bevers Role of divalency in the high-affinity binding of anticardiolipin antibody-beta 2-glycoprotein I complexes to lipid membranes Biochemistry 35 1996 13833
57. G.M. Willems, M.P. Janssen, P. Comfurius, M. Galli, R.F. Zwaal, and E.M. Bevers Competition of annexin V and anticardiolipin antibodies for binding to phosphatidylserine containing membranes Biochemistry 39 2000 1982
58. H. Wurm Beta 2-glycoprotein-I (apolipoprotein H) interactions with phospholipid vesicles Int. J. Biochem. 16 1984 511