Identification of novel VH1/J558 immunoglobulin germline genes of C57BL/6 (Ighb) allotype

Molecular Immunology

Volumn 42, Issue 11, 2005, Pages 1293-1301

  Chang, Sooghee ^a   Mohan, Chandra ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Anti DNA; Antibodies; C57BL 6; J558; Repertoire

Indexed keywords

ANTINUCLEAR ANTIBODY; IMMUNOGLOBULIN;

ALLOTYPE; ANIMAL CELL; ARTICLE; DATA BASE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC VARIABILITY; J558 GENE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VH1 GENE;

ANIMALS; BASE SEQUENCE; COMPLEMENTARITY DETERMINING REGIONS; DNA; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN ALLOTYPES; IMMUNOGLOBULIN HEAVY CHAINS; MICE; MICE, INBRED C57BL;

EID: 20444410409     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2004.12.008     Document Type: Article

References (29)

1. P.N. Akolkar, S.K. Sikder, S.B. Bhattacharya, J. Liao, F. Gruezo, S.L. Morrison, and E.A. Kabat Different VL and VH germ-line genes are used to produce similar combining sites with specificity for alpha(1,6)dextrans J. Immunol. 138 1987 4472 4479
2. J.R. Benson Improved ion-exchange resins Methods Enzymol. 47 1977 19 31
3. P.H. Brodeur, and R. Riblet The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. Part I: one hundred Igh-V genes comprise seven families of homologous genes Eur. J. Immunol. 14 1984 922 930
4. A.L. Bothwell, M. Paskind, M. Reth, T. Imanishi-Kari, K. Rajewsky, and D. Baltimore Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region Cell 24 1981 625 637
5. J.B. Cohen, and D. Givol Allelic immunoglobulin VH genes in two mouse strains: possible germline gene recombination EMBO J. 2 1983 2013 2018
6. J.B. Cohen, K. Effron, G. Rechavi, Y. Ben-Neriah, R. Zakut, and D. Givol Simple DNA sequences in homologous flanking regions near immunoglobulin VH genes: a role in gene interaction? Nucleic Acids Res. 10 1982 3353 3370
7. L. Chen, S. Chang, and C. Mohan Molecular Signatures of anti-ssDNA, anti-dsDNA, and anti-nucleosome autoantibody heavy chains Mol. Immunol. 39 2002 333 347
8. D. Eilat, and W.F. Anderson Structure-function correlates of autoantibodies to nucleic acids: lessons from immunochemical, genetic and structural studies Mol. Immunol. 31 1994 1377 1390
9. A. Ehlich, V. Martin, W. Muller, and K. Rajewsky Analysis of the B-cell progenitor compartment at the level of single cells Curr. Biol. 4 1994 573 583
10. D. Givol, R. Zakut, K. Effron, G. Rechavi, D. Ram, and J.B. Cohen Diversity of germ-line immunoglobulin VH genes Nature 292 1981 426 430
11. H. Gu, D. Tarlinton, W. Muller, K. Rajewsky, and I. Forster Most peripheral B cells in mice are ligand selected J. Exp. Med. 173 1991 1357 1371
12. B.B. Haines, C.V. Angeles, A.P. Parmelee, P.A. McLean, and P.H. Brodeur Germline diversity of the expressed BALB/c VhJ558 gene family Mol. Immunol. 38 2001 9 18
13. H.D. Jeong, J.L. Komisar, E. Kraig, and J.M. Teale Strain-dependent expression of VH gene families J. Immunol. 140 1988 2436 2441
14. Kabat, E.A., Wu, T.T., Perry, H.M., Gottesman, K.S., Foeller, C., 1991. Sequences of proteins of immunological interest. US Department of Health and Human Services, 1-2592.
15. R. Kofler, S. Geley, H. Kofler, and A. Helmberg Mouse variable-region gene families: complexity, polymorphism and use in non-autoimmune responses Immunol. Rev. 128 1992 5 21
16. A.B. Kantor, C.E. Merrill, and J.L. Hillson Construction of cDNA from single unstimulated mouse B lymphocytes: method and application to the study of expressed antibody repertoire in FACS-sorted murine B cell subsets D.M. Weir L.A. Herzenberg C.C. Blackwell Handbook of Experimental Immunology 1996 Blackwell Scientific Edinburgh
17. K.D. Klonowski, L.L. Primiano, and M. Monestier Atypical VH-D-JH rearrangements in newborn autoimmune MRL mice J. Immunol. 162 1999 1566 1572
18. k1 germline gene J. Immunol. 171 2003 3886 3894
19. N. Maizels, and A. Bothwell The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes Cell 43 1985 715 720
20. T.N. Marion, D.M. Tillman, N.T. Jou, and R.J. Hill Selection of immunoglobulin variable regions in autoimmunity to DNA Immunol. Rev. 128 1992 123 149
21. L. Morel, C. Mohan, Y. Yu, B. Croker, X.-H. Tian, A. Deng, and E.K. Wakeland Functional dissection of SLE pathogenesis using congenic mouse strains J. Immunol. 158 1997 6019 6028
22. C. Mohan, E. Alas, L. Morel, P. Yang, and E.K. Wakeland Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes J. Clin. Invest. 101 1998 1362 1372
23. M.Z. Radic, and M. Weigert Genetic and structural evidence for antigen selection of anti-DNA antibodies Annu. Rev. Immunol. 12 1994 487 520
24. K.M. Sheehan, and P.H. Brodeur Molecular cloning of the primary IgH repertoire: a quantitative analysis of VH gene usage in adult mice EMBO J. 8 1989 2313 2320
25. C. Schiff, M. Milili, and M. Fougereau Functional and pseudogenes are similarly organized and may equally contribute to the extensive antibody diversity of the IgVHII family EMBO J. 4 1985 1225 1230
26. P. Sedrak, K. Hsu, and C. Mohan Molecular signatures of anti-nuclear antibodies: contribution of heavy chain framework residues Mol. Immunol. 40 2003 483 563
27. E. Ten Boekel, F. Melchers, and A. Rolink The status of Ig loci rearrangements in single cells from different stages of B cell development Int. Immunol. 7 1995 1013 1019
28. G.E. Wu, and C.J. Paige VH gene family utilization is regulated by a locus outside of the VH region J. Exp. Med. 167 1988 1499 1504
29. G.D. Yancopoulos, and F.W. Alt Developmentally controlled and tissue-specific expression of unrearranged VH gene segments Cell 40 2004 271 281