Effect of nifekalant, a class III anti-arrhythmic agent, on Ca2+ waves in rat intact trabeculae

Circulation Journal

Volumn 69, Issue 6, 2005, Pages 739-745

  Hirose, Masanori ^a   Miura, Masahito ^a   Wakayama, Yuji ^a   Endo, Hideaki ^a   Sugai, Yoshinao ^a   Stuyvers, Bruno D M Y ^b   Kagaya, Yutaka ^a   Watanabe, Jun ^a   Ter Keurs, Henk E D J ^b   Shirato, Kunio ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Ca2+ wave; Nifekalant; Trabecula

Indexed keywords

ANTIARRHYTHMIC AGENT; CALCIUM ION; FURA 2; NIFEKALANT; SILICON;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; DOSE RESPONSE; DRUG MECHANISM; HEART MUSCLE; HEART RIGHT VENTRICLE; HEART VENTRICLE ARRHYTHMIA; MEMBRANE POTENTIAL; MUSCLE CONTRACTION; NONHUMAN; RAT; SARCOMERE; SARCOPLASMIC RETICULUM;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART VENTRICLES; PYRIMIDINONES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 20444400900     PISSN: 13469843     EISSN: None     Source Type: Journal    
DOI: 10.1253/circj.69.739     Document Type: Article

References (42)

1. Shiga T, Ando S, Suzuki T, Matsuda N, Kasanuki H. Reverse use-dependent QT prolongation during infusion of nifekalant in a case of recurrent ventricular tachycardia with old myocardial infarction. J Electrocardiol 2001; 34: 77-80.
2. Suzuki K, Furukawa T, Koyama Y, Sagawa T, Nishimura M, Yamanaka M. Concentration-dependent block of sodium current in guinea pig ventricular myocytes by a class III antiarrhythmic agent, MS-551. J Cardiovasc Pharmacol 1998; 32: 819-825.
3. Mori K, Hara Y, Saito T, Masuda Y, Nakaya H. Anticholinergic effects of class III antiarrhythmic drugs in guinea pig atrial cells: Different molecular mechanisms. Circulation 1995; 91: 2834-2843.
4. Nakaya H, Tohse N, Takeda Y, Kanno M. Effects of MS-551, a new class III antiarrhythmic drug, on action potential and membrane currents in rabbit ventricular myocytes. Br J Pharmacol 1993; 109: 157-163.
5. + channels in guinea-pig ventricular cells. Br J Pharmacol 1996; 119: 133-141.
6. + currents in Xenopus oocytes. Br J Pharmacol 1993; 109: 866-872.
7. Sen L, Cui G, Sakaguchi Y, Singh BN. Electrophysiological effects of MS-551, a new class III agent: Comparison with d1-sotalol in dogs. J Pharmacol Exp Ther 1998; 285: 687-694.
8. Tanabe T, Iwamoto T, Iwata O, Aikawa M, Kusuzaki S, Handa S, et al. Electrophysiologic and blood-flow responses in the endocardium and epicardium to disopyramide and MS-551 during myocardial ischemia in the dog. J Cardiovasc Pharmacol 1999; 34: 275-286.
9. Isomoto S, Konoe A, Centurion OA, Hayano M, Kaibara M, Hirata T, et al. Electrophysiological effects of MS-551 in humans: A class III antiarrhythmic agent. Pacing Clin Electrophysiol 1995; 18: 2022-2027.
10. Takenaka K, Yasuda S, Miyazaki S, Kurita T, Sutani Y, Morii I, et al. Initial experience with nifekalant hydrochloride (MS-551), a novel class III antiarrhythmic agent, in patients with acute extensive infarction and severe ventricular dysfunction. Jpn Circ J 2001; 65: 60-62.
11. Chen J, Komori S, Li B, Tamura K, Hashimoto K. IK independent class III actions of MS-551 compared with sematilide and dofetilide during reperfusion in anaesthetized rats. Br J Pharmacol 1996; 119: 937-942.
12. ter Keurs HEDJ, Zhang YM, Miura M. Damage-induced arrhythmias: Reversal of excitation-contraction coupling. Cardiovasc Res 1998; 40: 444-455.
13. 2+ overload evokes a transient outward current in guinea-pig ventricular myocytes. Circ J 2002; 66: 87-92.
14. 2+ waves during triggered propagated contractions in intact trabeculae: Determinants of the velocity of propagation. Circ Res 1999; 84: 1459-1468.
15. Daniels MCG, Fedida D, Lamont C, ter Keurs HEDJ. Role of the sarcolemma in triggered propagated contractions in rat cardiac trabeculae. Circ Res 1991; 68: 1408-1421.
16. 2+ waves can be arrhythmogenic through the increase in delayed afterdepolarizations in intact rat trabeculae (abstract). Circulation 2001; 104(Suppl S): 519.
17. 2+ waves and triggered propagated contractions. Am J Physiol 2001; 281: H2133-H2142.
18. Vermeulen JT, McGuire MA, Opthof T, Coronel R, de Bakker JM, Klopping C, et al. Triggered activity and automaticity in ventricular trabeculae of failing human and rabbit hearts. Cardiovasc Res 1994; 28: 1547-1554.
19. Pogwizd SM. Non-re-entrant mechanisms underlying spontaneous ventricular arrhythmias in a model of non-ischemic heart failure in rabbits. Circulation 1995; 92: 1034-1048.
20. Janse MJ. Electrophysiology of arrhythmias. Arch Mal Coeur Vaiss 1999; 92: 9-16.
21. 2+-content in isolated rat and rabbit myocardium. J Mol Cell Cardiol 2000; 32: 2249-2258.
22. Pond AL, Scheve BK, Benedict AT, Petrecca K, Van Wagoner DR, Shrier A, et al. Expression of distinct ERG proteins in rat, mouse, and human heart: Relation to functional IKr channels. J Biol Chem 2000; 275: 5997-6006.
23. + current modulates repolarization and excitation-contraction coupling in adult mouse ventricle. J Physiol 1997; 504(Pt 3): 557-563.
24. Sah R, Ramirez RJ, Kaprielian R, Backx PH. Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes. J Physiol 2001; 533(Pt 1): 201-214.
25. Clark RB, Bouchard RA, Salinas-Stefanon E, Sanchez-Chapula J, Giles WR. Heterogeneity of action potential waveforms and potassium currents in rat ventricle. Cardiovasc Res 1993; 27: 1795-1799.
26. Fedida D, Bouchard RA. Mechanisms for the positive inotropic effect of alpha 1-adrenoceptor stimulation in rat cardiac myocytes. Circ Res 1992; 71: 673-688.
27. 2+ current in single rat ventricular cells. Circ Res 1993; 73: 286-300.
28. Hoey A, Amos GJ, Ravens U. Comparison of the action potential prolonging and positive inotropic activity of DPI 201-106 and BDF 9148 in human ventricular myocardium. J Mol Cell Cardiol 1994; 26: 985-994.
29. 2+ transients and contraction. J Physiol 1991; 432: 283-312.
30. Bers DM, Lederer WJ, Berlin JR. Intracellular Ca transients in rat cardiac myocytes: Role of Na-Ca exchange in excitation-contraction coupling. Am J Physiol 1990; 258: C944-C954.
31. Bouchard RA, Clark RB, Giles WR. Effects of action potential duration on excitation-contraction coupling in rat ventricular myocytes: Action potential voltage-clamp measurements. Circ Res 1995; 76: 790-801.
32. 2+] in mammalian ventricle: Dynamic control by cellular processes. Annu Rev Physiol 1990; 52: 467-485.
33. Tande PM, Refsum H. Class III antiarrhythmic action linked with positive inotropy: Acute electrophysiological and inotropic effects of amiodarone in vitro. Pharmacol Toxicol 1990; 66: 18-22.
34. Beregi JP, Escande D, Coudray N, Mery P, Mestre M, Chemla D, et al. Positive inotropic effects of RP 62719, a new pure class III antiarrhythmic agent, on guinea pig myocardium. J Pharmacol Exp Ther 1992; 263: 1369-1376.
35. Antonaccio MJ, Gomoll A. Pharmacologic basis of the antiarrhythmic and hemodynamic effects of sotalol. Am J Cardiol 1993; 72: A27-A37.
36. 2+ release causes myocyte depolarization: Underlying mechanism and threshold for triggered action potentials. Circ Res 2000; 87: 774-780.
37. Ashihara T, Yao T, Namba T, Kawase A, Ikeda T, Nakazawa K, et al. Afterdepolarizations promote the transition from ventricular tachycardia to fibrillation in a three-dimensional model of cardiac tissue. Circ J 2002; 66: 505-510.
38. Xie JT, Yuan CS, Zhou Z, January CT. Enhancement of delayed afterdepolarizations and triggered activity by class III antiarrhythmic drugs: Multiple effects of E-4031 and dofetilide. Methods Find Exp Clin Pharmacol 2000; 22: 67-76.
39. Pogwizd SM, McKenzie JP, Cain ME. Mechanisms underlying spontaneous and induced ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy. Circulation 1998; 98: 2404-2414.
40. 2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res 1999; 85: 1009-1019.
41. Huang C, Bao M, Jiang H, Liu J, Yang B, Wang T. Differences in the changing trends of monophasic action potential duration and effective refractory period of the ventricular myocardium after myocardial infarction in vivo. Circ J 2004; 68: 1205-1209.
42. Tatewaki T, Inagaki M, Kawada T, Shishido T, Yanagiya Y, Takaki H, et al. Biphasic response of action potential duration to sudden sympathetic stimulation in anesthetized cats. Circ J 2003; 67: 876-880.