Thirteen-week feeding study of thaumatin (a natural proteinaceous sweetener), sterilized by electron beam irradiation, in Sprague-Dawley rats

Food and Chemical Toxicology

Volumn 43, Issue 8, 2005, Pages 1297-1302

  Hagiwara, A ^a   Yoshino, H ^a,b   Sano, M ^a   Kawabe, M ^a   Tamano, S ^a   Sakaue, K ^c   Nakamura, M ^c   Tada, M ^d   Imaida, K ^e   Shirai, T ^b  

^a Daiyukai Research Institute for Medical Science   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c SAN EI GEN F F I INC   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

^e KAGAWA UNIVERSITY   (Japan)

Author keywords

Electron beam irradiation; Natural proteinaceous sweetener; Sprague Dawley rats; Subchronic toxicity; Thaumatin

Indexed keywords

SWEETENING AGENT; THAUMATIN;

ANIMAL EXPERIMENT; ARTICLE; BIOCHEMISTRY; BLOOD ANALYSIS; CONTROLLED STUDY; DIETARY INTAKE; ELECTRON BEAM; FEEDING; FEMALE; FLUID INTAKE; FOOD INTAKE; HEMATOLOGY; HISTOPATHOLOGY; INSTRUMENT STERILIZATION; IRRADIATION; MALE; NONHUMAN; OPHTHALMOLOGY; ORGAN WEIGHT; RAT; RAT STRAIN; SEX ROLE; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; URINALYSIS;

ADMINISTRATION, ORAL; ANIMALS; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOOD IRRADIATION; GAMMA RAYS; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PLANT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; STERILIZATION; SWEETENING AGENTS;

EID: 20444390535     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2005.04.001     Document Type: Article

References (18)

1. W.F. Daniell Katemfe, or the miraculous fruit of Soudan Pharm. J. 14 1855 158 160
2. L. Edens, L. Heslinga, R. Klok, A.M. Ledeboer, J. Maat, M.Y. Toonen, C. Visser, and C.T. Verrips Cloning of cDNA encoding the sweet-tasting plant protein thaumatin and its expression in Escherichia coli Gene 18 1982 1 12
3. European Commission, 1998. Opinion of the Scientific Commission on Food on the irradiation of eight foodstuffs (expressed on 17.09.1998). Available from: 〈 http//europa.eu.int/comm/food/fs/sc/scf/out15_en.html 〉.
4. FAO, 1984. Codex General Standard for Irradiated Foods and Recommended International Code of Practice for the Operation of Radiation Facilities Used for the Treatment of Food. Rome, Food and Agriculture Organization of the United Nations (CAC/Vol. XV-Ed. 1).
5. I. Faus Recent developments in the characterization and biotechnological production of sweet-tasting proteins Appl. Microbiol. Biotechnol. 53 2000 145 151
6. J.D. Higginbotham, D.J. Snodin, K.K. Eaton, and J.W. Daniel Safety evaluation of thaumatin (Talin protein) Food Chem. Toxicol. 21 1983 815 823
7. S. Huang, T.J. Herald, and D.D. Mueller Effect of electron beam irradiation on physical, physiochemical, and functional properties of liquid egg yolk during frozen storage Poult. Sci. 76 1997 1607 1615
8. R.B. Iyengar, P. Smits, F. van der Ouderaa, H. van der Wel, J.V. Brouwershaven, P. Ravestein, G. Richters, and P.D. van Wassenaar The complete amino acid sequence of the sweet protein Thaumatin I Eur. J. Biochem. 96 1979 193 204
9. JECFA, 1985. 605. Thaumatin. Toxicological Evaluation of Certain Food Additives and Contaminants: Report of the 29th Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), World Health Organization, Geneva (WHO Food Additive Series 20). WHO, Geneva.
10. K. Sakaue, M. Takeuchi, Y. Higashimura, Y. Murata, and M. Tada Functional aspects of the protein sweetener, thaumatin by irradiation Food Irradiation 32 1997 13 19 (in Japanese)
11. K. Sakaue, M. Takeuchi, Y. Murata, J. Yoshifuji, T. Hayashi, and M. Tada Sterilization of proteinaceous food additives by irradiation: molecular alteration of plasma proteins by electron beam irradiation Jpn. J. Food Chem. 5 1998 100 105 (in Japanese)
12. H. van der Wel, and K. Loeve Isolation and characterization of thaumatin I and II, the sweet-tasting proteins from Thaumatococcus daniellii Benth Eur. J. Biochem. 31 1972 221 225
13. H. van der Wel, T.C. van Soest, and E.C. Royers Crystallization and crystal data of Thaumatin I, a sweet-tasting protein from Thaumatococcus daniellii Benth FEBS Lett. 56 1975 316 317
14. B.L. Welch The generalization of Student's problem when several different population variances are involved Biometrika 34 1947 28 35
15. WHO, 1981. Wholesomeness of Irradiated Food: Report of a Joint FAO/IAEA/WHO Expert Committee. World Health Organization, Geneva (WHO Technical Report Series, No. 659).
16. WHO, 1994. Safety and Nutritional Adequacy of Irradiated Food. World Health Organization, Geneva.
17. WHO, 1999. High-dose Irradiation: Wholesomeness of Food Irradiated with Doses Above 10 kGy: Report of a Joint FAO/IAEA/WHO Expert Committee. World Health Organization, Geneva (WHO Technical Report Series, No. 890).
18. M. Witty, and J.D. Higginbotham Thaumatin 1994 CRC Press Boca Raton