Recent developments in the characterization and biotechnological production of sweet-tasting proteins

Applied Microbiology and Biotechnology

Volumn 53, Issue 2, 2000, Pages 145-151

  Faus, I ^a  

^a Laboratory of Biotechnology   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

SWEETENING AGENT; VEGETABLE PROTEIN;

BIOSYNTHESIS; BIOTECHNOLOGY; NONHUMAN; PHYTOCHEMISTRY; RECOMBINANT DNA TECHNOLOGY; SHORT SURVEY; SWEETNESS;

EID: 0034002755     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530050001     Document Type: Short Survey

References (38)

1. Abe K, Yamashita H, Arai S, Kurihara Y (1992) Molecular cloning of curculin, a novel taste-modifying protein with a sweet taste. Biochim Biophys Acta 1130: 232-234
2. 137] thaumatin I polypeptides. PCT Patent WO 90/05775
3. Caldwell JE, Abildgaard F, Dzakula Z, Ming D, Hellekant G, Markley L (1998) Solution structure of the thermostable sweet-tasting protein brazzein. Nat Struct Biol 5-6: 427-431
4. Cvetkovic A, Hranisavljevic J (1997) Molecular features in the antifungal activity of thaumatin-like proteins from barley grain. J Serb Chem Soc 62: 777-786
5. Daniell WF (1855) Katemfe or the miraculous fruit of Soudan. Pharm J 14: 158
6. Dansby R (1997) Sweet science: overexpression of monellin in yeast. Nature Biotechnol 15: 419-420
7. Edens L, van der Wel H (1985) Microbial synthesis of the sweet-tasting protein thaumatin. Trends Biotechnol 3: 61-64
8. Edens L, Heslinga L, Klok R, Ledeboer AM, Maat J, Toonen MY, Visser CT, Verrips T (1982) Cloning of cDNA encoding the sweet tasting plant protein thaumatin and its expression in Escherichia coli. Gene 18: 1-12
9. Faus I, Patiño C, Del Río JL, Del Moral C, Barroso HS, Bladé J, Rubio V (1997) Expression of a synthetic gene encoding the sweet-tasting protein thaumatin in the filamentous fungus Penicillium roquefortii. Biotechnol Lett 19: 1185-1191
10. Faus I, Del Moral C, Adroer N, Del Río JL, Patiño C, Barroso HS, Casas C, Bladé J, Rubio V (1998) Secretion of the sweet-tasting protein thaumatin by recombinant strains of Aspergillus niger var. awamori. Appl Microbiol Biotechnol 49: 393-398
11. Grijspaardt-Vink C (1996) Progress and Stagnation in EU Food Legislation. Food Technol 50: 25
12. Hellekant BG, Ming D (1994) Brazzein sweetener. US Patent 5346998
13. Illingworth C, Larson G, Hellenkant G (1988) Secretion of the sweet-tasting protein thaumatin by Bacillus subtilis. Biotechnol Lett 10: 587-592
14. Illingworth C, Larson G, Hellenkant G (1989) Secretion of the sweet-tasting protein thaumatin by Streptomyces lividans. J Ind Microbiol 4: 37-42
15. Ishikawa K, Ota M, Ariyoshi Y, Sasaki H, Tanokura M, Ming D, Caldwell J, Abildgaad F (1996) Crystallization and preliminary X-ray analysis of brazzein, a new sweet protein. Acta Crystallogr D52: 577-578
16. Kim SH, Kang CH, Kim R, Cho JM, Lee YB, Lee TK (1989) Redesigning a sweet protein: increased stability and renaturability. Prot Eng 2: 571-575
17. Kondo K, Miura Y, Sone H, Kobayashi K, Iijima H (1997) High-level expression of a sweet protein, monellin, in the food yeast Candida utilis. Nat Biotechnol 15: 453-457
18. Kurihara Y (1994) Sweet proteins in general. In: Witty M, Higginbotham JD (eds) Thaumatin. CRC, Boca Raton, pp 1-18
19. Lee JH, Weickmann LJ, Koduri RK, Ghosh-Dastidar P, Saito K, Blair LC, Date T, Lai JS, Hollenberg SM, Kenda RL (1988) Biochemistry 27: 5101-5107
20. Liu X, Hu Z, Maeda S, Aiuchi T, Nakaya K, Kurihara Y (1993) Purification, complete amino acid sequence and structure characterization of the heat stable sweet protein, mabinlin II. Eur J Biochem 211: 281-287
21. Masuda Y, Nirasawa S, Nakaya K, Kurihara Y (1995) Cloning and sequencing of a cDNA encoding a taste-modifying protein, miraculin. Gene 161: 175-177
22. Ming D, Hellekant G (1994) Brazzein, a new high potency sweet protein from Pentadiplandra brazzeana B. FEBS Lett 355:106-108
23. Morris JA, Cagan RH (1972) Purification of monellin, the sweet principle of Dioscoreophyllum cumminsii. Biochim Biophys Acta 261: 114-122
24. Nirasawa S, Nishino T, Katahira M, Uesugi S, Hu Z, Kurihara Y (1994) Structures of heat-stable and unstable homologues of the sweet protein mabinlin. Eur J Biochem 223: 989-995
25. Overbeeke N (1989) Synthesis and processing of thaumatin in yeast. Biotechnol Ser (Yeast Gen Eng) 13: 305-318
26. Peñarrubia L, Kim R, Giovannoni J, Kim SH, Fisher R (1992) Production of the sweet protein monellin in transgenic plants. Biotechnol 10: 561-564
27. Sun S, Zuo W, Tu H, Xiong L (1996) Plant proteins: engineering for improved quality. Ann NY Acad Sci 792: 37-42
28. Sun S, Xiong L, Hu Z, Chen H (1997) Recombinant sweet protein mabinlin. PCT Patent WO 97/00945
29. Tattersall DB, van Heeswijck R, Hoj PD (1997) Identification and characterization of a fruit-specific thaumatin-like protein that accumulates at very high levels in conjunction with the onset of sugar accumulation and berry softening in grapes. Plant Physiol 114: 759-769
30. Theerasilp S, Kurihara Y (1988) Complete purification and characterization of the taste-modifying protein, miraculin, from miracle fruit. J Biol Chem 263: 11536-11539
31. Theerasilp S, Hitotsuya H, Nakajo S, Nakaya K, Nakamura Y, Kurihara Y (1989) Complete amino acid sequence and structure characterization of the taste-modifying protein, miraculin. J Biol Chem 264: 6655-6659
32. Tomes DT (1997) Methods and compositions for production of plant foodstuffs with enhanced sweet component flavor. PCT Patent WO 97/42333
33. Wel H van der, Loeve K (1972) Isolation and characterization of thaumatin I and II, the sweet tasting proteins from Thaumatococcus daniellii Benth. Eur J Biochem 31: 221-225
34. Wel H van der, Larson G, Hladik A, Hladik CM, Hellekant G, Glaser D (1989) Isolation and characterization of pentadin, the sweet principle of Pentadiplandra brazzeana Baillon. Chem Senses 14: 73-79
35. Witty M (1990) Preprothaumatin II is processed to biological activity in Solanum tuberosum. Biotechnol Lett 12: 131-136
36. Witty M, Higginbotham JD (1994) Thaumatin. CRC, Boca Raton
37. Xiong L, Sun S (1996) Molecular cloning and transgenic expression of the sweet protein mabinlin in potato tubers. Plant Physiol 111: 57
38. Yamashita H, Theerasilp A, Nakaya T, Nakamura Y, Kurihara Y (1990) Purification and complete amino acid sequence of a new type of sweet protein with taste-modifying activity, curculin. J Biol Chem 265: 15770-15775