Gαq-coupled receptor signaling enhances adenylate cyclase type 6 activation

Biochemical Pharmacology

Volumn 70, Issue 1, 2005, Pages 113-120

  Beazely, Michael A ^a   Watts, Val J ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Adenylate cyclase; Calcium; G protein; Muscarinic receptor; PKC

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE TYPE 5; ADENYLATE CYCLASE TYPE 6; CALMODULIN; CARBACHOL; CYCLIC AMP; G PROTEIN ALPHA(Q) COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR; ISOENZYME; MUSCARINIC RECEPTOR; PROTEIN KINASE C; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT;

ARTICLE; BIOACCUMULATION; CALCIUM SIGNALING; CELLULAR DISTRIBUTION; CHELATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SUBUNIT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR INTRINSIC ACTIVITY; CELL CULTURE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; CALCIUM; CARBACHOL; CELLS, CULTURED; CYCLIC AMP; ENZYME ACTIVATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; PROTEIN KINASE C; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 20444390522     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.04.007     Document Type: Article

References (33)

1. N. Defer, M. Best-Belpomme, and J. Hanoune Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase Am J Physiol Renal Physiol 279 2000 F400 F416
2. Y. Chern Regulation of adenylyl cyclase in the central nervous system Cell Signal 12 2000 195 204
3. D.M. Cooper Molecular and cellular requirements for the regulation of adenylate cyclases by calcium Biochem Soc Trans 31 2003 912 915
4. J.L. Guillou, H. Nakata, and D.M. Cooper Inhibition by calcium of mammalian adenylyl cyclases J Biol Chem 274 1999 35539 35545
5. Y. Ishikawa, S. Katsushika, L. Chen, N.J. Halnon, J. Kawabe, and C.J. Homcy Isolation and characterization of a novel cardiac adenylylcyclase cDNA J Biol Chem 267 1992 13553 13557
6. 2+ of AC5 revealed by mutants and chimeric constructs J Biol Chem 277 2002 33139 33147 [Epub 13 June 2002]
7. S. Katsushika, L. Chen, J. Kawabe, R. Nilakantan, N.J. Halnon, and C.J. Homcy Cloning and characterization of a sixth adenylyl cyclase isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family Proc Natl Acad Sci USA 89 1992 8774 8778
8. 2+)-inhibitable adenylyl cyclase in non-excitable cells J Biol Chem 270 1995 1149 1155
9. s cross-talk regulates collagen production in cardiac fibroblasts J Biol Chem 278 2003 24461 24468 [Epub 23 April 2003]
10. s) Am J Physiol Cell Physiol 278 2000 C154 C162
11. i3 and m3-mediated stimulation via Gβγq J Biol Chem 272 1997 21317 21324
12. M.A. Beazely, J.K. Alan, and V.J. Watts Protein kinase C and epidermal growth factor stimulation of Raf1 potentiates adenylyl cyclase type 6 activation in intact cells Mol Pharmacol 67 2005 250 259 [Epub 6 October 2004]
13. V.J. Watts, R. Taussig, R.L. Neve, and K.A. Neve Dopamine D2 receptor-induced heterologous sensitization of adenylyl cyclase requires Galphas: characterization of Galphas-insensitive mutants of adenylyl cyclase V Mol Pharmacol 60 2001 1168 1172
14. K. Hellevuo, M. Yoshimura, M. Kao, P.L. Hoffman, D.M. Cooper, and B. Tabakoff A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line Biochem Biophys Res Commun 192 1993 311 318
15. M.G. Cumbay, and V.J. Watts Novel regulatory properties of human type 9 adenylate cyclase J Pharmacol Exp Ther 310 2004 108 115 [Epub 2 March 2004]
16. 2+ entry sites J Biol Chem 271 1996 12438 12444
17. E.J. Choi, S.T. Wong, T.R. Hinds, and D.R. Storm Calcium and muscarinic agonist stimulation of type I adenylylcyclase in whole cells J Biol Chem 267 1992 12440 12442
18. N.T. Burford, and S.R. Nahorski Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is mediated by Gs alpha and is not a consequence of phosphoinositidase C activation Biochem J 315 1996 883 888
19. 11 proteins in transfected Cos-7 cells J Biol Chem 267 1992 1811 1817
20. J. Wess Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications Annu Rev Pharmacol Toxicol 44 2004 423 450
21. 2+)-sensitive adenylyl cyclases Biochem J 297 1994 437 440
22. D. Chin, and A.R. Means Calmodulin: a prototypical calcium sensor Trends Cell Biol 10 2000 322 328
23. M. Bahler, and A. Rhoads Calmodulin signaling via the IQ motif FEBS Lett 513 2002 107 113
24. G.A. Wayman, J. Wei, S. Wong, and D.R. Storm Regulation of type I adenylyl cyclase by calmodulin kinase IV in vivo Mol Cell Biol 16 1996 6075 6082
25. J. Wei, G. Wayman, and D.R. Storm Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo J Biol Chem 271 1996 24231 24235
26. 2+ entry J Biol Chem 273 1998 9297 9305
27. 2+]i oscillations in HEK293 cells JBC 276 2001 5613 5621
28. 2+ entry requires localization in cholesterol-rich domains J Biol Chem 275 2000 26530 26537
29. 2+) entry J Biol Chem 277 2002 6025 6031 [Epub 13 December 2001]
30. q overexpression induces cardiac contractile failure in mice Proc Natl Acad Sci USA 94 1997 8121 8126
31. q)- mediated cardiac hypertrophy and ventricular dysfunction Mol Pharmacol 57 2000 278 287
32. q overexpressing mouse FEBS Lett 458 1999 236 240
33. D.M. Roth, H. Bayat, J.D. Drumm, M.H. Gao, J.S. Swaney, and A. Ander Adenylyl cyclase increases survival in cardiomyopathy Circulation 105 2002 1989 1994