Application of high-performance liquid chromatography-electrospray ionization-mass spectrometry to measure microsomal membrane transport of glucuronides

Analytical Biochemistry

Volumn 342, Issue 1, 2005, Pages 45-52

  Staines, Adam G ^a   Burchell, Brian ^a   Bánhegyi, Gábor ^b   Mandl, József ^b   Csala, Miklós ^a,b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Electrospray ionization mass spectrometry; Glucuronide; High performance liquid chromatography; Membrane; Microsome; Rapid filtration; Transport

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; MEMBRANES; MICROFILTRATION; SUBSTRATES;

ELECTROSPRAY IONIZATION MASS SPECTROMETRY; ELECTROSPRAY TANDEM MASS SPECTROMETRY; GLUCURONIDES; MEASUREMENT TECHNIQUES; MICROSOME; PHYSIOLOGICAL CONCENTRATIONS; SIMULTANEOUS DETECTION; TRANSPORT;

ELECTROSPRAY IONIZATION;

1 NAPHTHOL GLUCURONIDE; 4 NITROPHENYLGLUCURONIDE; BETA ESTRADIOL GLUCURONIDE; GLUCURONIDE; MORPHINE; MORPHINE GLUCURONIDE; PHENOLPHTHALEIN GLUCURONIDE; SUGAR ACID; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; DEGRADATION; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; FILTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MICROSOME MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 20444382029     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ab.2005.04.003     Document Type: Article

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