Parotid gland-sparing 3-dimensional conformal radiotherapy results in less severe dry mouth in nasopharyngeal cancer patients: A dosimetric and clinical comparison with conventional radiotherapy

Radiotherapy and Oncology

Volumn 75, Issue 2, 2005, Pages 204-209

  Jen, Yee Min ^a   Shih, Rompin ^a   Lin, Yaoh Shiang ^a   Su, Wan Fu ^a   Ku, Chih Hung ^b   Chang, Chiou Shiung ^a   Shueng, Pei Wei ^a,c   Hwang, Jing Min ^a   Liu, Dai Wei ^a   Chao, Hsing Lung ^a   Lin, Hon Yi ^a   Chang, Li Ping ^a   Shum, Weng Yoon ^a,d   Lin, Chun Shu ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^d JEN AI HOSPITAL   (Taiwan)

Author keywords

Nasopharyngeal neoplasms; Parotid gland; Three dimensional conformal radiotherapy; Xerostomia

Indexed keywords

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER SURVIVAL; COMPUTER ASSISTED RADIOTHERAPY; CONTROLLED STUDY; DISEASE SEVERITY; DOSIMETRY; FEMALE; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL ANALYSIS; NASOPHARYNX CANCER; PAROTID GLAND; PRIORITY JOURNAL; PROGNOSIS; RADIATION INJURY; TREATMENT OUTCOME; XEROSTOMIA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DOSE FRACTIONATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; PAROTID GLAND; RADIATION INJURIES; RADIOTHERAPY, CONFORMAL; XEROSTOMIA;

EID: 20444365800     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2005.03.005     Document Type: Article

References (25)

1. D. Antonadou, M. Pepelassi, M. Synodinou, M. Puglisi, and N. Throuvalas Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer Int J Radiat Oncol Biol Phys 52 2002 739 747
2. J.A. Bogers, R.W. van der Maazen, and A.G. Visser Conformal photon-beam radiotherapy of prostate carcinoma Eur Urol 41 2002 515 522
3. K.S. Chao, J.O. Deasy, and J. Markman A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results Int J Radiat Oncol Biol Phys 49 2001 907 916
4. A. Eisbruch, R.K. Ten Haken, H.M. Kim, L.H. Marsh, and J.A. Ship Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer Int J Radiat Oncol Biol Phys 45 1999 577 587
5. L. Franzen, U. Funegard, T. Ericson, and R. Henriksson Parotid gland function during and following radiotherapy of malignancies in the head and neck. A consecutive study of salivary flow and patient discomfort Eur J Cancer 28 1992 457 462
6. A.L. Hanlon, D. Watkins Bruner, R. Peter, and G.E. Hanks Quality of life study in prostate cancer patients treated with three-dimensional conformal radiation therapy: comparing late bowel and bladder quality of life symptoms to that of the normal population Int J Radiat Oncol Biol Phys 49 2001 51 59
7. C.Y. Hsiung, E.D. Yorke, and C.S. Chui Intensity-modulated radiotherapy versus conventional three-dimensional conformal radiotherapy for boost or salvage treatment of nasopharyngeal carcinoma Int J Radiat Oncol Biol Phys 53 2002 638 647
8. M.A. Hunt, M.J. Zelefsky, and S. Wolden Treatment planning and delivery of intensity-modulated radiation therapy for primary nasopharynx cancer Int J Radiat Oncol Biol Phys 49 2001 623 632
9. Y.M. Jen, Y.H. Lin, and W.F. Su Dose Escalation Using Twice-per-day Radiotherapy Technique for Nasopharyngeal Carcinoma: Does Heavier Dosing Result in a Happier Ending? Int J Radiat Oncol Biol Phys 54 2002 14 22
10. G.E. Kim, J. Lim, and H.C. Park A feasibility study using three-dimensional conformal boost technique in locally advanced carcinoma of the nasopharynx Acta Oncol 40 2001 582 587
11. G.J. Kutcher, Z. Fuks, and H. Brenner Three-dimensional photon treatment planning for carcinoma of the nasopharynx Int J Radiat Oncol Biol Phys 21 1991 169 182
12. N. Lee, P. Xia, and J.M. Quivey Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience Int J Radiat Oncol Biol Phys 48 2002 12 22
13. K.Y. Liang, and S.L. Zeger Longitudinal data analysis using generalized linear models Biometrika 73 1986 13 22
14. S.A. Libel, G.J. Kutcher, and L.N. Harrison Improved dose distributions for 3D conformal boost treatments in carcinoma of the nasopharynx Int J Radiat Oncol Biol Phys 20 1991 823 833
15. T. Nishioka, H. Shirato, and T. Arimoto Reduction of radiation-induced xerostomia in nasopharyngeal carcinoma using CT simulation with laser patient marking and three-field irradiation technique Int J Radiat Oncol Biol Phys 38 1997 705 712
16. L.E. Norberg, and P.G. Lundquist Aspects of salivary gland radiosensitivity: effects of sialogogues and irradiation Arch Otorhinolaryngol 246 1989 200 204
17. H. Pyykonen, M. Malmstrom, V.J. Oikarinen, M. Salmo, and M. Vehkalahti Late effect of radiation treatment of tongue and floor-of-mouth cancer on the dentition, saliva secretion, mucous membranes and the lower jaw Int J Oral Maxillofac Surg 15 1986 401 409
18. J.G. Rosenman, J.S. Halle, and M.A. Socinski High-dose conformal radiotherapy for treatment of stage IIIA/IIIB non-small-cell lung cancer: technical issues and results of a phase I/II trial Int J Radiat Oncol Biol Phys 54 2002 348 356
19. J.K. Ryu, K. Winter, and J.M. Michalski Interim report of toxicity from 3D conformal radiation therapy (3D-CRT) for prostate cancer on 3DOG/RTOG 9406, level III (79.2 Gy) Int J Radiat Oncol Biol Phys 54 2002 1036 1046
20. L.C. Stephens, G.K. King, L.J. Peters, K.K. Ang, T.E. Schultheiss, and J.H. Jardine Unique radiosensitivity of serous cells in rhesus monkey submandibular glands Am J Pathol 124 1986 479 487
21. M. Tubiana, and F. Eschwege Conformal radiotherapy and intensity-modulated radiotherapy: clinical data Acta Oncol 39 2000 555 567
22. S.L. Wolden, M.J. Zelefsky, and M.A. Hunt Failure of a 3D conformal boost to improve radiotherapy for nasopharyngeal carcinoma Int J Radiat Oncol Biol Phys 49 2001 1229 1234
23. E.D. Yorke, A. Jackson, and K.E. Rosenzweig Dose-volume factors contributing to the incidence of radiation pneumonitis in non-small-cell lung cancer patients treated with three-dimensional conformal radiation therapy Int J Radiat Oncol Biol Phys 54 2002 329 339
24. S.L. Zeger, and K.Y. Liang Longitudinal data analysis for discrete and continuous outcomes Biometrics 42 1986 121 130
25. R.P. Zimmerman, R.J. Mark, L.M. Tran, and G.F. Juillard Concomitant pilocarpine during head and neck irradiation is associated with decreased posttreatment xerostomia Int J Radiat Oncol Biol Phys 37 1997 571 575