Malaria parasite transporters as a drug-delivery strategy

Trends in Parasitology

Volumn 21, Issue 7, 2005, Pages 299-301

  Biagini, Giancarlo A ^a   Ward, Stephen A ^a   Bray, Patrick G ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHOLINE; PENTAMIDINE;

ANTIMALARIAL ACTIVITY; CELL MEMBRANE TRANSPORT; CHEMOTHERAPY; CHOLINE UPTAKE; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; ERYTHROCYTE MEMBRANE; MALARIA; NONHUMAN; PLASMODIUM; SHORT SURVEY;

ANIMALS; ANTIMALARIALS; CELL MEMBRANE; ERYTHROCYTES; HAPLORHINI; HUMANS; MALARIA; MEMBRANE TRANSPORT PROTEINS; PLASMODIUM;

EID: 20444363391     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2005.05.013     Document Type: Short Survey

References (37)

1. R.W. Snow The past, present and future of childhood malaria mortality in Africa Trends Parasitol. 17 2001 593 597
2. G.A. Biagini Antimalarial chemotherapy: young guns or back to the future? Trends Parasitol. 19 2003 479 487
3. K. Kirk Membrane transport in the malaria-infected erythrocyte Physiol. Rev. 81 2001 495 537
4. +-ATPase J. Biol. Chem. 274 1999 33213 33219
5. R.J.W. Allen, and K. Kirk The membrane potential of the intraerythrocytic malaria parasite Plasmodium falciparum J. Biol. Chem. 279 2004 11264 11272
6. J.L. Elliott Transport of lactate and pyruvate in the intraerythrocytic malaria parasite, Plasmodium falciparum Biochem. J. 355 2001 733 739
7. +-coupled pantothenate transport in the intracellular malaria parasite J. Biol. Chem. 276 2001 18115 18121
8. C.A. Homewood, and K.D. Neame Malaria and the permeability of the host erythrocyte Nature 252 1974 718 719
9. S. Kutner Alterations in membrane permeability of malaria-infected human erythrocytes are related to the growth stage of the parasite Biochim. Biophys. Acta 687 1982 113 117
10. K. Kirk Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel J. Biol. Chem. 269 1994 3339 3347
11. S.A. Desai A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite Nature 406 2000 1001 1005
12. A. Alkhalil Plasmodium falciparum likely encodes the principal anion channel on infected human erythrocytes Blood 104 2004 4279 4286
13. G. Decherf Anionic channels in malaria-infected human red blood cells Blood Cells Mol. Dis. 32 2004 366 371
14. S. Kutner On the mode of action of phlorizin as an antimalarial agent in in vitro cultures of Plasmodium falciparum Biochem. Pharmacol. 36 1987 123 129
15. K. Kirk Glibenclamide and meglitinide block the transport of low molecular weight solutes into malaria-infected erythrocytes FEBS Lett. 323 1993 123 128
16. K. Kirk, and H.A. Horner In search of a selective inhibitor of the induced transport of small solutes in Plasmodium falciparum-infected erythrocytes: effects of arylaminobenzoates Biochem. J. 311 1995 761 768
17. H.M. Staines Furosemide analogues as potent inhibitors of the new permeability pathways of Plasmodium falciparum-infected human erythrocytes Mol. Biochem. Parasitol. 133 2004 315 318
18. J. Kanaani, and H. Ginsburg Effects of cinnamic acid derivatives on in vitro growth of Plasmodium falciparum and on the permeability of the membrane of malaria-infected erythrocytes Antimicrob. Agents Chemother. 36 1992 1102 1108
19. M.L. Go Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes Antimicrob. Agents Chemother. 48 2004 3241 3245
20. T. Joet Validation of the hexose transporter of Plasmodium falciparum as a novel drug target Proc. Natl. Acad. Sci. U. S. A. 100 2003 7476 7479
21. K.J. Saliba Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O-3-hexose derivative FEBS Lett. 570 2004 93 96
22. H. Ginsburg, and W.D. Stein New permeability pathways induced by the malarial parasite in the membrane of its host erythrocyte: potential routes for targeting of drugs into infected cells Biosci. Rep. 7 1987 455 463
23. A.M. Gero New malaria chemotherapy developed by utilization of a unique parasite transport system Curr. Pharm. Des. 9 2003 867 877
24. J.M. Upston, and A.M. Gero Parasite-induced permeation of nucleosides in Plasmodium falciparum malaria Biochim. Biophys. Acta 1236 1995 249 258
25. N.S. Carter Isolation and functional characterization of the PfNT1 nucleoside transporter gene from Plasmodium falciparum J. Biol. Chem. 275 2000 10683 10691
26. G.A. Biagini Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs Blood 104 2004 3372 3377
27. G.A. Biagini Heme binding contributes to antimalarial activity of bis-quaternary ammoniums Antimicrob. Agents Chemother. 47 2003 2584 2589
28. A.M. Stead Diamidine compounds: selective uptake and targeting in Plasmodium falciparum Mol. Pharmacol. 59 2001 1298 1306
29. M.L. Ancelin Antimalarial activity of 77 phospholipid polar head analogs: close correlation between inhibition of phospholipid metabolism and in vitro Plasmodium falciparum growth Blood 91 1998 1426 1437
30. M.L. Ancelin Potent inhibitors of Plasmodium phospholipid metabolism with a broad spectrum of in vitro antimalarial activities Antimicrob. Agents Chemother. 47 2003 2590 2597
31. K. Wengelnik A class of potent antimalarials and their specific accumulation in infected erythrocytes Science 295 2002 1311 1314
32. G.G. Holz Jr Lipids and the malarial parasite Bull. WHO. 55 1977 237 248
33. H.J. Vial, and M.L. Ancelin Malarial lipids I.W. Sherman Malaria: Parasite Biology, Pathogenesis and Protection 1998 ASM Press 159 175
34. H.J. Vial Transport of phospholipid synthesis precursors and lipid trafficking into malaria-infected erythrocytes Novartis Found. Symp. 226 1999 74 83
35. A.M. Lehane Choline uptake into the malaria parasite is energized by the membrane potential Biochem. Biophys. Res. Commun. 320 2004 311 317
36. S.W. Rabkin Effect of amiodarone and desethylamiodarone on choline uptake and phosphatidylcholine biosynthesis in cultured chick cardiac myocytes J. Mol. Cell. Cardiol. 22 1990 965 974
37. R. Zufferey, and C.B. Mamoun Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs Mol. Biochem. Parasitol. 125 2002 127 134