메뉴 건너뛰기




Volumn 43, Issue 5, 2004, Pages 287-290

Single-enantiomer drugs: Elegant science, disappointing effects

Author keywords

[No Author keywords available]

Indexed keywords

CITALOPRAM; ESCITALOPRAM; ESOMEPRAZOLE; LEVALBUTEROL; OMEPRAZOLE; SALBUTAMOL;

EID: 2042470125     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-200443050-00002     Document Type: Review
Times cited : (49)

References (23)
  • 2
    • 0034712572 scopus 로고    scopus 로고
    • Chiral switches
    • Tucker GT. Chiral switches. Lancet 2000; 355: 1085-7
    • (2000) Lancet , vol.355 , pp. 1085-1087
    • Tucker, G.T.1
  • 3
    • 0036206870 scopus 로고    scopus 로고
    • Stereoselective pharmacokinetics and pharmacodynamics of anti-asthma agents
    • Vakily M, Mehvar R, Brocks D, et al. Stereoselective pharmacokinetics and pharmacodynamics of anti-asthma agents. Ann Pharmacother 2002; 36: 693-701
    • (2002) Ann Pharmacother , vol.36 , pp. 693-701
    • Vakily, M.1    Mehvar, R.2    Brocks, D.3
  • 4
    • 0036324727 scopus 로고    scopus 로고
    • Impact of stereoselectivity on the pharmacokinetics and pharmacodynamics of anti-arrhythmic drugs
    • Mehvar R, Brocks DR, Vakily M. Impact of stereoselectivity on the pharmacokinetics and pharmacodynamics of anti-arrhythmic drugs. Clin Pharmacokinet 2002; 41: 533-58
    • (2002) Clin Pharmacokinet , vol.41 , pp. 533-558
    • Mehvar, R.1    Brocks, D.R.2    Vakily, M.3
  • 5
    • 0036948923 scopus 로고    scopus 로고
    • Stereochemistry and drug efficacy and development: Relevance of chirality to antidepressant and antipsychotic drugs
    • Baker GB, Prior TL. Stereochemistry and drug efficacy and development: relevance of chirality to antidepressant and antipsychotic drugs. Ann Med 2002; 34: 537-43
    • (2002) Ann Med , vol.34 , pp. 537-543
    • Baker, G.B.1    Prior, T.L.2
  • 6
    • 0032901485 scopus 로고    scopus 로고
    • Recent advances in the pharmacokinetics of local anaesthetics: Long-acting amide enantiomers and continuous infusions
    • Thomas JM, Schug SA. Recent advances in the pharmacokinetics of local anaesthetics: long-acting amide enantiomers and continuous infusions. Clin Pharmacokinet 1999; 36: 67-83
    • (1999) Clin Pharmacokinet , vol.36 , pp. 67-83
    • Thomas, J.M.1    Schug, S.A.2
  • 7
    • 0032452106 scopus 로고    scopus 로고
    • Racemic beta-blockers: Fixed combinations of different drugs
    • Stoschitzky K, Zernig G, Lindner W. Racemic beta-blockers: fixed combinations of different drugs. J Clin Basic Cardiol 1998; 1: 14-8
    • (1998) J Clin Basic Cardiol , vol.1 , pp. 14-18
    • Stoschitzky, K.1    Zernig, G.2    Lindner, W.3
  • 10
    • 0036782116 scopus 로고    scopus 로고
    • Putting chirality to work: The strategy of chiral switches
    • Oct
    • Agranat I, Caner H, Caldwell J. Putting chirality to work: the strategy of chiral switches. Nat Rev Drug Discov 2002 Oct; 1 (10): 753-68
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.10 , pp. 753-768
    • Agranat, I.1    Caner, H.2    Caldwell, J.3
  • 11
    • 0036083854 scopus 로고    scopus 로고
    • Great expectations in stereochemistry: Focus on antidepressants
    • DeVane CL, Boulton DW. Great expectations in stereochemistry: focus on antidepressants. CNS Spectrums 2002; 7 Suppl. 1: 28-33
    • (2002) CNS Spectrums , vol.7 , Issue.1 SUPPL. , pp. 28-33
    • DeVane, C.L.1    Boulton, D.W.2
  • 12
    • 2042429142 scopus 로고    scopus 로고
    • Do single stereoisomer drugs provide value?
    • Anon. Do single stereoisomer drugs provide value? Therapeutics Letter 2002 [online]. Available from URL: http://www.ti.ubc.ca/PDF/45.pdf [Accessed 2004 Feb 11]
    • Therapeutics Letter 2002 [Online]
  • 13
    • 0345991251 scopus 로고    scopus 로고
    • Escitalopram: Superior to citalopram or chiral chimera?
    • Jan-Feb
    • Svensson S, Mansfield PR. Escitalopram: superior to citalopram or chiral chimera? Psychother Psychosom 2004 Jan-Feb; 73(1): 10-6
    • (2004) Psychother Psychosom , vol.73 , Issue.1 , pp. 10-16
    • Svensson, S.1    Mansfield, P.R.2
  • 14
    • 0033127928 scopus 로고    scopus 로고
    • Enantiomers of bronchodilating beta2-adrenoceptor agonists: Is there cause for concern?
    • Waldeck B. Enantiomers of bronchodilating beta2-adrenoceptor agonists: is there cause for concern? J Allergy Clin Immunol 1999; 103: 742-8
    • (1999) J Allergy Clin Immunol , vol.103 , pp. 742-748
    • Waldeck, B.1
  • 15
    • 0036080635 scopus 로고    scopus 로고
    • Efficacy comparison of escitalopram and citalopram in the treatment of major depressive disorder: Pooled analysis of placebo-controlled trials
    • Gorman JM, Korotzer A, Su G. Efficacy comparison of escitalopram and citalopram in the treatment of major depressive disorder: pooled analysis of placebo-controlled trials. CNS Spectrums 2002; 7 Suppl. 1: 40-4
    • (2002) CNS Spectrums , vol.7 , Issue.1 SUPPL. , pp. 40-44
    • Gorman, J.M.1    Korotzer, A.2    Su, G.3
  • 16
    • 0033785204 scopus 로고    scopus 로고
    • Esomeprazole improves healing and symptom resolution as compared with omeprazole in reflux oesophagitis patients: A randomized controlled trial: The Esomeprazole Study Investigators
    • Oct
    • Kahrilas PJ, Falk GW, Johnson DA, et al. Esomeprazole improves healing and symptom resolution as compared with omeprazole in reflux oesophagitis patients: a randomized controlled trial: The Esomeprazole Study Investigators. Aliment Pharmacol Ther 2000 Oct; 14 (10): 1249-58
    • (2000) Aliment Pharmacol Ther , vol.14 , Issue.10 , pp. 1249-1258
    • Kahrilas, P.J.1    Falk, G.W.2    Johnson, D.A.3
  • 17
    • 0032417246 scopus 로고    scopus 로고
    • Improved bronchodilation with levalbuterol compared with racemic albuterol in patients with asthma
    • Nelson HS, Bensch G, Pleskow WW, et al. Improved bronchodilation with levalbuterol compared with racemic albuterol in patients with asthma. J Allergy Clin Immunol 1998; 102: 943-52
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 943-952
    • Nelson, H.S.1    Bensch, G.2    Pleskow, W.W.3
  • 18
    • 0035071459 scopus 로고    scopus 로고
    • Efficacy and safety of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: A randomized controlled trial
    • Mar
    • Richter JE, Kahrilas PJ, Johanson J, et al. Efficacy and safety of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: a randomized controlled trial. Am J Gastroenterol 2001 Mar; 96 (3): 656-65
    • (2001) Am J Gastroenterol , vol.96 , Issue.3 , pp. 656-665
    • Richter, J.E.1    Kahrilas, P.J.2    Johanson, J.3
  • 19
    • 2042532183 scopus 로고    scopus 로고
    • Healthy Skepticism. AdWatch on Nexium [online]. Available from URL: http://www.healthyskepticism.org/adwatch/au/2003/nexium.asp [Accessed 2004 Feb 11]
    • AdWatch on Nexium [Online]
  • 20
    • 0042858121 scopus 로고    scopus 로고
    • Beta2-agonist eutomers: A rational option for the treatment of asthma?
    • Boulton DW, Fawcett JP. Beta2-agonist eutomers: a rational option for the treatment of asthma? Am J Respir Med 2002; 1: 305-11
    • (2002) Am J Respir Med , vol.1 , pp. 305-311
    • Boulton, D.W.1    Fawcett, J.P.2
  • 21
    • 0036675340 scopus 로고    scopus 로고
    • Levalbuterol has not been established to have therapeutic advantage over racemic albuterol
    • Asmus MJ, Hendeles L, Weinberger M, et al. Levalbuterol has not been established to have therapeutic advantage over racemic albuterol [letter]. J Allergy Clin Immunol 2002; 110: 325
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 325
    • Asmus, M.J.1    Hendeles, L.2    Weinberger, M.3
  • 22
    • 0035217690 scopus 로고    scopus 로고
    • Low-dose levalbuterol in children with asthma: Safety and efficacy in comparison with placebo and racemic albuterol
    • Milgrom H, Skoner DP, Bensch G, et al. Low-dose levalbuterol in children with asthma: safety and efficacy in comparison with placebo and racemic albuterol. J Allergy Clin Immunol 2001; 108: 938-45
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 938-945
    • Milgrom, H.1    Skoner, D.P.2    Bensch, G.3
  • 23
    • 0037121236 scopus 로고    scopus 로고
    • Medicines, health and commerce: A global perspective of the pharmaceutical industry: Industry as a medicines provider
    • Henry DA, Lexchin J. Medicines, health and commerce: a global perspective of the pharmaceutical industry: industry as a medicines provider. Lancet 2002; 360: 1590-5
    • (2002) Lancet , vol.360 , pp. 1590-1595
    • Henry, D.A.1    Lexchin, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.