Trapidil inhibits platelet-derived growth factor-induced migration via protein kinase A and RhoA/Rho-associated kinase in rat vascular smooth muscle cells

European Journal of Pharmacology

Volumn 515, Issue 1-3, 2005, Pages 28-33

  Ishikura, Kenji ^a   Fujita, Hisayo ^a   Hida, Mariko ^a   Awazu, Midori ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Angioplasty; Forskolin; Protein serine threonine kinase; Rho GTP binding protein; Trapidil

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PLATELET DERIVED GROWTH FACTOR; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRAPIDIL;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

AMIDES; ANIMALS; CELL MOVEMENT; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; ENZYMES; FORSKOLIN; HUMANS; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOQUINOLINES; MUSCLE, SMOOTH, VASCULAR; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RATS; RHOA GTP-BINDING PROTEIN; SULFONAMIDES; THYMIDINE; TRAPIDIL; TRITIUM;

EID: 20344391382     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.04.013     Document Type: Article

References (28)

1. T. Bethke, H. Mehl, W. Meyer, W. Schmitz, H. Scholz, K. Thomas, and H. Wenzlaff Effects of the triazolopyrimidine trapidil on force of contraction, beating frequency and phosphodiesterase I-IV activity in guinea-pig hearts Arzneimittelforschung 41 1991 461 468
2. D. Bönisch, A.-A. Weber, M. Wittpoth, M. Osinski, and K. Schrör Antimitogenic effects of trapidil in coronary artery smooth muscle cells by direct activation of protein kinase A Mol. Pharmacol. 54 1998 241 248
3. 2+ by atriopeptin and 8-bromo-cyclic GMP is mediated by cyclic GMP-dependent protein kinase J. Biol. Chem. 264 1989 1146 1155
4. M.L. Edin, A.K. Howe, and R.L. Juliano Inhibition of PKA blocks fibroblast migration in response to growth factors Exp. Cell Res. 270 2001 214 222
5. G.A. Ferns, E.W. Raines, K.H. Sprugel, A.S. Motani, M.A. Reidy, and R. Ross Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF Science 253 1991 1129 1132
6. D.M. Gamm, E.J. Baude, and M.D. Uhler The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo J. Biol. Chem. 271 1996 15736 15742
7. L. Gesualdo, S. Di Paolo, E. Ranieri, and F.P. Schena Trapidil inhibits human mesangial cell proliferation: effect on PDGF β-receptor binding and expression Kidney Int. 46 1994 1002 1009
8. L.M. Graves, K.E. Bornfeldt, E.W. Raines, B.C. Potts, S.G. MacDonald, R. Ross, and E.G. Krebs Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells Proc. Natl. Acad. Sci. U. S. A. 90 1993 10300 10304
9. L.M. Graves, K.E. Bornfeldt, J.S. Sidhu, G.M. Argast, E.W. Raines, R. Ross, C.C. Leslie, and E.G. Krebs Platelet-derived growth factor stimulates protein kinase A through a mitogen-activated protein kinase-dependent pathway in human arterial smooth muscle cells J. Biol. Chem. 271 1996 505 511
10. A. Hirayama, K. Kodama, Y. Yui, H. Nonogi, T. Sumiyoshi, H. Origasa, S. Hosoda, C. Kawai Japan Multicenter Investigation for Cardiovascular Diseases-Mochida Investigators Effect of trapidil on cardiovascular events in patients with coronary artery disease (results from the Japan Multicenter Investigation for Cardiovascular Diseases-Mochida [JMIC-M]) Am. J. Cardiol. 92 2003 789 793
11. M. Hoshiya, and M. Awazu Trapidil inhibits platelet-derived growth factor-stimulated mitogen-activated protein kinase cascade Hypertension 31 1998 665 671
12. C. Indolfi, E.V. Avvedimento, E. Di Lorenzo, G. Esposito, A. Rapacciuolo, P. Giuliano, D. Grieco, L. Cavuto, A.M. Stingone, I. Ciullo, G. Condorelli, and M. Chiariello Activation of cAMP-PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury Nat. Med. 3 1997 775 779
13. A. Maresta for the STARC Investigators Trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty: results of the randomized, double-blind STARS study Circulation 90 1994 2710 2715
14. H. Ohnishi, H. Kosuzume, Y. Hayashi, K. Yamaguchi, Y. Suzuki, and R. Itoh Effects of trapidil on thromboxane A2-induced aggregation of platelets, ischemic changes in heart and biosynthesis of thromboxane A2 Prostaglandins Med. 6 1981 269 281
15. H. Ohnishi, K. Yamaguchi, S. Shimada, M. Sato, H. Funato, Y. Katsuki, T. Dabasaki, Y. Suzuki, Y. Saitoh, and A. Kumagai An evidence for 'response to injury' hypothesis Life Sci. 31 1982 2595 2602
16. Waf1/Cip1 Nature 394 1998 295 299
17. D. Palmer, K. Tsoi, and D.H. Maurice Synergistic inhibition of vascular smooth muscle cell migration by phosphodiesterase 3 and phosphodiesterase 4 inhibitors Circ. Res. 82 1998 852 861
18. X.D. Ren, W.B. Kiosses, and M.A. Schwartz Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton EMBO J. 18 1999 578 585
19. N. Sawada, H. Itoh, K. Ueyama, J. Yamashita, K. Doi, T.H. Chun, M. Inoue, K. Masatsugu, T. Saito, Y. Fukunaga, S. Sakaguchi, H. Arai, N. Ohno, M. Komeda, and K. Nakao Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries Circulation 101 2000 2030 2033
20. R.S. Schwartz, D.R. Holmes Jr., and E.J. Topol The restenosis paradigm revisited: an alternative proposal for cellular mechanisms J. Am. Coll. Cardiol. 20 1992 1284 1293
21. J.D. Scott Cyclic nucleotide-dependent protein kinases Pharmacol. Ther. 50 1991 123 145
22. T.M. Seasholtz, M. Majumdar, D.D. Kaplan, and J.H. Brown Rho and rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration Circ. Res. 84 1999 1186 1193
23. R. Shibata, H. Kai, Y. Seki, S. Kato, M. Morimatsu, K. Kaibuchi, and T. Imaizumi Role of Rho-associated kinase in neointima formation after vascular injury Circulation 103 2001 284 289
24. O.J. Sichelschmidt, C. Hahnefeld, T. Hohlfeld, F.W. Herberg, and K. Schror Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity Cardiovasc. Res. 58 2003 602 610
25. J. Sun, X. Sui, J.A. Bradbury, D.C. Zeldin, M.S. Conte, and J.K. Liao Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids Circ. Res. 90 2002 1020 1027
26. Y. Takai, T. Sasaki, K. Tanaka, and H. Nakanishi Rho as a regulator of the cytoskeleton Trends Biochem. Sci. 20 1995 227 231
27. J.D. Weber, W. Hu, S.C. Jefcoat Jr., D.M. Raben, and J.J. Baldassare Ras-stimulated extracellular signal-related kinase 1 and RhoA activates coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27KIP1 J. Biol. Chem. 272 1997 32966 32971
28. K. Yasunari, M. Kohno, T. Hasuma, T. Horio, H. Kano, K. Yokokawa, M. Minami, and J. Yoshikawa Dopamine as a novel antimigration and antiproliferative factor of vascular smooth muscle cells through dopamine D1-like receptors Arterioscler. Thromb. Vasc. Biol. 17 1997 3164 3173