Initial dosage adjustment for oral administration of tacrolimus using the intestinal MDR1 level in living-donor liver transplant recipients

Transplantation Proceedings

Volumn 37, Issue 4, 2005, Pages 1728-1729

  Masuda, S ^a   Goto, M ^a   Okuda, M ^a   Ogura, Y ^b   Oike, F ^b   Kiuchi, T ^b   Tanaka, K ^b   Inui, K ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; MULTIDRUG RESISTANCE PROTEIN 1; TACROLIMUS;

CLINICAL TRIAL; CONFERENCE PAPER; CORRELATION ANALYSIS; GENETIC VARIABILITY; HUMAN; JEJUNUM; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MOLECULAR DYNAMICS; POPULATION RESEARCH; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ADMINISTRATION, ORAL; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION; GENETIC MARKERS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL MUCOSA; LIVER TRANSPLANTATION; LIVING DONORS; P-GLYCOPROTEIN; RNA, MESSENGER; TACROLIMUS;

EID: 20344379217     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2005.02.081     Document Type: Conference Paper

References (5)

1. S. Masuda, M. Goto, T. Kiuchi Enhanced expression of enterocyte P-glycoprotein depresses cyclosporine bioavailability in a recipient of living-donor liver transplantation Liver Transplant 9 2003 1108
2. M. Goto, S. Masuda, H. Saito C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation Pharmacogenetics 12 2002 451
3. T. Hashida, S. Masuda, S. Uemoto Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living-donor liver transplantation Clin Pharmacol Ther 69 2001 308
4. T. Ishikawa, A. Tsuji, K. Inui The genetic polymorphism of drug transporters functional analysis approaches Pharmacogenomics 5 2004 67
5. M. Goto, S. Masuda, T. Kiuchi CYP3A5 *1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation Pharmacogenetics 14 2004 471