Inhibition of nitric oxide synthesis blocks the inhibitory response to capsaicin in intestinal circular muscle preparations from different species

Life Sciences

Volumn 76, Issue 24, 2005, Pages 2773-2782

  Benko, Rita ^a   Lazar, Zsofia ^a   Undi, Sarolta ^a   Illenyi, Laszlo ^a   Antal, Andras ^b   Horvath, Örs Peter ^a   Rumbus, Zoltan ^a   Wolf, Matyas ^a   Maggi, Carlo A ^c   Bartho, Lorand ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b Department of Surgery   (Hungary)

^c Menarini Ricerche SpA   (Italy)

Author keywords

Appendix; Capsaicin; Colonic circular muscle (mouse, guinea pig); Ileum (human); Nitric oxide; Tetrodotoxin

Indexed keywords

CAPSAICIN; MUSCLE RELAXANT AGENT; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TETRODOTOXIN; VANILLOID RECEPTOR 1; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL TISSUE; APPENDIX; ARTICLE; COLON; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME INHIBITION; ENZYME SYNTHESIS; FEMALE; GUINEA PIG; ILEUM; INTESTINE MUSCLE; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; RECEPTOR POTENTIAL; RECEPTOR SENSITIVITY; SENSORY NERVE; WILD TYPE;

EID: 20144389113     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.07.033     Document Type: Article

References (35)

1. Y. Aimi, M. Fujimura, S.R. Vincent, and H. Kimura Localization of NADPH-diaphorase-containing neurons in sensory ganglia of the rat Journal of Comparative Neurology 306 3 1991 382 392
2. S. Anavi-Goffer, and A.A. Coutts Cellular distribution of vanilloid VR1 receptor immunoreactivity in the guinea-pig myenteric plexus European Journal of Pharmacology 458 1-2 2003 61 71
3. L. Barthó, and R. Lefebvre Nitric oxide induces acetylcholine-mediated contractions in the guinea-pig small intestine Naunyn-Schmiedeberg's Archives of Pharmacology 350 5 1994 582 584
4. L. Barthó, G. Pethö, A. Antal, P. Holzer, and J. Szolcsányi Two types of relaxation due to capsaicin in the guinea-pig ileum Neuroscience Letters 81 1-2 1987 146 150
5. L. Barthó, G. Kóczán, P. Holzer, C.A. Maggi, and J. Szolcsányi Antagonism of the effects of calcitonin gene-related peptide and of capsaicin on the guinea-pig isolated ileum by human alpha-calcitonin gene-related peptide(8-37) Neuroscience Letters 129 1 1991 156 159
6. 2 receptors mediate atropine-resistant ileal circular muscle contractions evoked by capsaicin European Journal of Pharmacology 259 2 1994 187 193
7. L. Barthó, G. Horváth, and L. Lénárd Jr. Lack of anticholinergic effect of L-NAME in the small intestine European Journal of Pharmacology 370 3 1999 279 282
8. L. Barthó, L. Lénárd Jr., R. Patacchini, V. Halmai, M. Wilhelm, P. Holzer, and C.A. Maggi Tachykinin receptors are involved in the "local efferent" motor response to capsaicin in the guinea-pig small intestine and oesophagus Neuroscience 90 1 1999 221 228
9. L. Barthó, Zs. Lázár, L. Lénárd Jr., R. Benkó, G. Tóth, B. Penke, J. Szolcsányi, and C.A. Maggi Evidence for the involvement of ATP but not of VIP/PACAP or nitric oxide, in the excitatory effect of capsaicin in the small intestine European Journal of Pharmacology 392 3 2000 183 188
10. L. Barthó, R. Benkó, Zs. Lázár, L. Illényi, and Ö.P. Horváth Nitric oxide is involved in the relaxant effect of capsaicin in the human sigmoid colon circular muscle Naunyn-Schmiedeberg's Archives of Pharmacology 366 5 2002 496 500
11. L. Barthó, R. Benkó, R. Patacchini, G. Pethö, U. Holzer-Petsche, P. Holzer, Z. Lázár, S. Undi, L. Illényi, A. Antal, and Ö.P. Horváth Effects of capsaicin on visceral smooth muscle: a valuable tool for sensory neurotransmitter identification European Journal of Pharmacology 500 1-3 2004 143 157
12. M.J. Caterina, and D. Julius The vanilloid receptor: a molecular gateway to the pain pathway Annual Reviews of Neuroscience 24 2001 487 517
13. T. Croci, X. Emonds-Alt, G. LeFur, and L. Manara In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR140333 and SR48968 in different rat and guinea-pig intestinal segments Life Sciences 56 4 1995 267 275
14. J.B. Davis, J. Gray, M.J. Gunthorpe, J.P. Hatcher, P.T. Davey, P. Overend, M.H. Harries, J. Latcham, C. Clapham, K. Atkinson, S.A. Hughes, K. Rance, E. Grau, A.J. Harper, P.L. Pugh, D.C. Rogers, S. Bingham, A. Randall, and S.A. Sheardown Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia Nature 405 6783 2000 183 187
15. T. Farkas-Szállási, J.M. Lundberg, Zs. Wiesenfeld-Hallin, T. Hökfelt, and Á. Szállási Increased levels of GMAP, VIP and nitric oxide synthase, and their mRNAs, in lumbar dorsal root ganglia of the rat following systemic resiniferatoxin treatment Neuroreport 6 16 1995 2230 2234
16. K. Hebeiss, and H. Kilbinger Differential effects of nitric oxide donors on basal and electrically evoked release of acetylcholine from guinea-pig myenteric neurones British Journal of Pharmacology 118 8 1996 2073 2078
17. P. Holzer Capsaicin: Cellular targets mechanisms of action and selectivity for thin sensory neurons Pharmacological Reviews 43 2 1991 143 201
18. P. Holzer, and L. Barthó Sensory neurons in the intestine P. Geppetti P. Holzer Neurogenic Inflammation 1996 CRC Press 153 167
19. A. Lecci, P. Santicioli, and C.A. Maggi Pharmacology of transmission to gastrointestinal muscle Current Opinion in Pharmacology 2 6 2002 630 641
20. C.A. Maggi, R. Patacchini, P. Santicioli, S. Giuliani, D. Turini, G. Barbanti, P. Beneforti, D. Misuri, and A. Meli Specific motor effects of capsaicin on human jejunum European Journal of Pharmacology 149 3 1988 393 395
21. C.A. Maggi, P. Santicioli, E. Del Bianco, P. Geppetti, G. Barbanti, D. Turini, and A. Meli Release of VIP- but not CGRP-like immunoreactivity by capsaicin from the human isolated small intestine Neuroscience Letters 98 3 1989 317 320
22. C.A. Maggi, S. Giuliani, P. Santicioli, R. Patacchini, S.I. Said, E. Theodorsson, D. Turini, G. Barbanti, A. Giachetti, and A. Meli Direct evidence for the involvement of vasoactive intestinal polypeptide in the motor response of the human isolated ileum to capsaicin European Journal of Pharmacology 185 2-3 1990 169 178
23. C.A. Maggi, E. Theodorsson, P. Santicioli, R. Patacchini, G. Barbanti, D. Turini, D. Renzi, and A. Giachetti Motor response of the human isolated colon to capsaicin and its relationship to release of vasoactive intestinal polypeptide Neuroscience 39 3 1990 833 841
24. C.-A. Maggi, S. Giuliani, and V. Zagorodnyuk Calcitonin gene-related peptide (CGRP) in the circular muscle of guinea-pig colon: role as inhibitory transmitter and mechanisms of relaxation Regulatory Peptides 61 1 1996 27 36
25. K.S. Murthy, J.R. Grider, J.G. Jin, and G.M. Makhlouf Interplay of VIP and nitric oxide in the regulation of neuromuscular activity in the gut Archives Internationales de Pharmacodynamie et de Therapie 329 1 1995 27 38
26. R. Patacchini, L. Barthó, R. De Giorgio, L. Lénárd Jr., V. Stanghellini, G. Barbara, A. Lecci, and C.A. Maggi Involvement of endogenous tachykinins and CGRP in the motor responses produced by capsaicin in the guinea-pig common bile duct Naunyn-Schmiedeberg's Archives of Pharmacology 360 3 1999 344 353
27. L.M. Patterson, H. Zheng, S.M. Ward, and H.R. Berthoud Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract Cell Tissue Research 311 3 2003 277 287
28. S. Poonyachoti, A. Kulkarniarla, and D.R. Brown Chemical coding of neurons expressing delta- and kappa-opioid receptor and type I vanilloid receptor immunoreactivities in the porcine ileum Cell Tissue Research 307 1 2002 23 33
29. M.J. Rand, and C.G. Li Nitric oxide as a neurotransmitter in peripheral nerves: nature of transmitter and mechanism of transmission Annual Reviews of Physiology 57 1995 659 682
30. K. Ren, and M.A. Ruda Nitric oxide synthase-containing neurons in sensory ganglia of the rat are susceptible to capsaicin-induced cytotoxicity Neuroscience 65 2 1995 505 511
31. G. Terenghi, V. Riveros-Moreno, L.D. Hudson, N.B. Ibrahim, and J.M. Polak Immunohistochemistry of nitric oxide synthase demonstrates immunoreactive neurons in spinal cord and dorsal root ganglia of man and rat Journal of the Neurological Sciences 118 1 1993 34 37
32. T. Thippeswamy, and R. Morris The roles of nitric oxide in dorsal root ganglion neurons Annals of New York Academy of Sciences 962 2002 103 110
33. S.M. Ward, J. Bayguinov, K.J. Won, D. Grundy, and H.R. Berthoud Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract Journal of Comparative Neurology 465 1 2003 121 135
34. B.J. Whittle Nitric oxide in gastrointestinal physiology and pathology L.R. Johnson Physiology of the Gastrointestinal Tract 3rd ed. 1994 Raven Press New York, NY 267 294
35. L. Zhang, S. Jones, K. Brody, M. Costa, and S.J.H. Brookes Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse American Journal of Physiology 286 6 2004 G983 G991