Lack of anticholinergic effect of N(G)-nitro-L-arginine methylester in the small intestine

European Journal of Pharmacology

Volumn 370, Issue 3, 1999, Pages 279-282

  Barthó, Loránd ^a   Horváth, Gábor ^a   Lénárd Jr , László ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Atropine; Ileum, guinea pig, rat, rabbit, mouse; L NAME (N(G) nitro L arginine methylester)

Indexed keywords

ATROPINE; MUSCARINIC RECEPTOR; N(G) NITROARGININE METHYL ESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICHOLINERGIC EFFECT; ARTICLE; FEMALE; GUINEA PIG; ILEUM; MALE; MOUSE; MUSCLE TWITCH; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SMALL INTESTINE;

ACETYLCHOLINE; ANIMALS; ATROPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; FEMALE; GUINEA PIGS; ILEUM; MALE; MICE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITROARGININE; RABBITS; RATS; RATS, WISTAR;

EID: 0344492737     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00167-3     Document Type: Article

References (13)

1. Barthó L., Holzer P. The inhibitory modulation of guinea-pig intestinal peristalsis caused by capsaicin involves calcitonin gene-related peptide and nitric oxide. Naunyn-Schmiedeberg's Arch. Pharmacol. 353:1995;102-109.
2. Barthó L., Kóczán G., Pethö G., Maggi C.A. Blockade of nitric oxide synthase inhibits nerve-mediated contraction in the rat small intestine. Neurosci. Lett. 145:1992;43-46.
3. G-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ. Res. 72:1993;387-395.
4. Chang H.-Y., Chen C.-W., Hsiue T.-R. Comparative effects of L-NOARG and L-NAME on basal blood flow and ACh-induced vasodilatation in rat diaphragmatic microcirculation. Br. J. Pharmacol. 120:1997;326-332.
5. Cheng D.Y., DeWitt B.J., McMahon T.J., Kadowitz P.J. Comparative effects of L-NNA and alkyl esters of L-NNA on pulmonary vasodilator responses to ACh, BK, and SP. Am. J. Physiol. 266:1994;H2416-H2422.
6. Feldman D.S., Terry A.V. Jr., Buccafusco J.J. Spinal muscarinic cholinergic and nitric oxide systems in cardiovascular regulation. Eur. J. Pharmacol. 313:1996;211-220.
7. G-nitro-L-arginine methyl ester: a muscarinic receptor antagonist? Fundam. Clin. Pharmacol. 11:1997;305-314.
8. Holzer P., Lippe I.Th., Lotfi-Tabrizi A., Lénárd L. Jr., Barthó L. Dual excitatory and inhibitory effect of nitric oxide on peristalsis in the guinea-pig intestine. J. Pharmacol. Exp. Ther. 280:1997;154-161.
9. Kilbinger H., Wolf D. Increase by NO synthase inhibitors of acetylcholine release from guinea-pig myenteric plexus. Naunyn-Schmiedeberg's Arch. Pharmacol. 349:1994;543-545.
10. G-nitro-L-arginine methyl ester on functionally characterized muscarinic receptors in anaesthetized cats. Eur. J. Pharmacol. 335:1997;199-204.
11. Paton W.D.M., Vizi E.S. The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea-pig ileum longitudinal muscle strip. Br. J. Pharmacol. 35:1969;10-20.
12. Theodorsson-Norheim E. Friedman and Quade tests: basic computer program to perform non-parametric two-way analysis of variance and multiple comparisons on ranks of several related samples. Comput. Biol. Med. 17:1987;85-99.
13. Waterman S.A., Costa M. The role of inhibitory motoneurons in peristalsis in the isolated guinea-pig small intestine. J. Physiol. (London). 474:1994;539-546.