Type and location of fluorescent probes incorporated into the potent μ-opioid peptide [Dmt1]DALDA affect potency, receptor selectivity and intrinsic efficacy

Journal of Peptide Research

Volumn 65, Issue 6, 2005, Pages 556-563

  Schiller, P W ^a   Berezowska, I ^a   Weltrowska, G ^a   Chen, H ^a   Lemieux, C ^a   Chung, N N ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Dmt1 DALDA; Fluorescent labels; Fluorescent opioid peptide analogues; Opioid activity profile in vitro; Opioid peptides

Indexed keywords

2',6' DIMETHYLTYROSINE DEXTRO ARGINYL BETA (6' DIMETHYLAMINO 2' NAPHTHOYL)ALANYLLYSINAMIDE; 2',6' DIMETHYLTYROSINE DEXTRO ARGINYLPHENYLALANYL BETA ALANINAMIDE; 2',6' DIMETHYLTYROSINE DEXTRO ARGINYLPHENYLALANYL BETA ANTHRANILOYL ALPHA,BETA DIAMINOPROPIONIC ACID AMIDE; 2',6' DIMETHYLTYROSINE DEXTRO ARGINYLPHENYLALANYL BETA DANSYL ALPHA,BETA DIAMINOPROPIONIC ACID AMIDE; 2',6' DIMETHYLTYROSINE DEXTRO ARGINYLPHENYLALANYL N ANTHRANILOYLLYSINAMIDE; 2',6' DIMETHYLTYROSINE DEXTRO ARGINYLPHENYLALANYL N ANTHRANILOYLLYSINE; 2',6' DIMETHYLTYROSINE DEXTRO ARGINYLPHENYLALANYLLYSINAMIDE; 2',6' DIMETHYLTYROSINE DEXTRO ARGINYLPHENYLALANYLLYSINE 5 (AMINOMETHYL)FLUORESCEIN; 2',6' DIMETHYLTYROSINE DEXTRO ARGINYLPHENYLALANYLLYSINE 6 (AMINOMETHYL)FLUORESCEIN; 6 DIMETHYLAMINO 2' NAPHTHOYL; BETA (6' DIMETHYLAMINO 2' NAPHTHOYL)ALANINE; DANSYL CHLORIDE; DELTA OPIATE RECEPTOR; FLUORESCENT DYE; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CARBOXY TERMINAL SEQUENCE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DISTRIBUTION; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; GUINEA PIG; ILEUM; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; VAS DEFERENS;

2-NAPHTHYLAMINE; ALANINE; ANIMALS; ANTHRANILIC ACIDS; DANSYL COMPOUNDS; FLUORESCEINS; FLUORESCENT DYES; MICE; OLIGOPEPTIDES; RECEPTORS, OPIOID, MU; TYROSINE;

EID: 20144383125     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.2005.00252.x     Document Type: Article

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