The controversial role of serum uric acid in essential hypertension: Relationships with indices of target organ damage

Journal of Human Hypertension

Volumn 19, Issue 3, 2005, Pages 211-217

  Tsioufis, C P ^a,b   Chatzis, D ^a   Vezali, E ^a   Dimitriadis, K ^a   Antoniadis, D ^a   Zervoudaki, A ^a   Lalos, S ^a   Kallikazaros, I ^a   Stefanadis, C ^a   Toutouzas, P ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b NONE   (Greece)

Author keywords

Left ventricular hypertrophy; Microalbuminuria; Serum uric acid

Indexed keywords

ALBUMIN; CHOLESTEROL; CREATININE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; URIC ACID;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; ECHOCARDIOGRAPHY; ESSENTIAL HYPERTENSION; FEMALE; GLUCOSE BLOOD LEVEL; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HUMAN; KIDNEY INJURY; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; MICROALBUMINURIA; MULTIPLE REGRESSION; OUTPATIENT; PATIENT REFERRAL; PROTEIN BLOOD LEVEL; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ALBUMINURIA; BIOLOGICAL MARKERS; BLOOD PRESSURE; BODY MASS INDEX; ECHOCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; MALE; MIDDLE AGED; NEPHELOMETRY AND TURBIDIMETRY; OUTPATIENTS; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; URIC ACID;

EID: 20144375080     PISSN: 09509240     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jhh.1001810     Document Type: Article

References (37)

1. European Society of Hypertension - European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 2003; 21: 1011-1053.
2. Persky VW et al. Uric acid: a risk factor for coronary heart disease? Circulation 1979; 59: 969-977.
3. Lehto S, Niskanen L, Ronnemaa T, Laakso M. Serum uric acid is a strong predictor of stroke in patients with non-dependent diabetes mellitus. Stroke 1998; 29: 635-639.
4. Levine W et al. Serum uric acid and 11.5 year mortality of middle-aged women: findings of the Chicago Heart Association Detection Project in Industry. J Clin Epidemiol 1989; 42: 257-267.
5. Frohlich ED. Uric acid: a risk factor for coronary heart disease. JAMA 1993; 270: 378-379.
6. Ward HJ. Uric acid as an independent risk factor in the treatment of hypertension. Lancet 1998; 352: 670-671.
7. Wannamethee SG, Shaper AG, Whincup PH. Serum urate and the risk of major coronary heart disease events. Heart 1997; 78: 147-153.
8. Fessel WJ. High uric acid as an indicator of cardiovascular disease: independence from obesity. Am J Med 1980; 68: 401-404.
9. Brand FN et al. Hyperuricemia as a risk factor of coronary heart disease: the Framingham study. Am J Epidemiol 1985; 121: 11-18.
10. Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med 1999; 131: 7-13.
11. Puig JG, Ruilope LM. Uric acid as a cardiovascular risk factor in arterial hypertension. J Hypertens 1999; 17: 869-872.
12. Jaques BC, Ginsberg MH. The role of cell surface proteins in platelet stimulation by monosodium urate crystals. Arthritis Rheum 1982; 25: 508-521.
13. Chapman PT et al. Endothelial activation in monosodium urate monohydrate crystal - induced inflammation: in vitro and in vivo studies on the role of tumor necrosis factor alpha and interleukin-1. Arthritis Rheum 1997; 40: 955-965.
14. Leoncini G et al. Microalbuminuria is an integrated marker of subclinical organ damage in primary hypertension. J Hum Hypertens 2002; 16: 399-404.
15. Sica DA, Weber D. The Losartan Intervention for Endpoint Reduction (LIFE) trial - have angiotensin receptor blockers come of age? J Clin Hypertens 2002; 4: 301-305.
16. The Joint National Committee on detection, evaluation and treatment of high blood pressure. The sixth report of the Joint National Committee on detection, evaluation and treatment of high blood pressure (JNC VI). Arch Intern Med 1997; 157: 2413-2446.
17. Schiller NB et al. Recommendations for quantitation of the left ventricular dimensions by two-dimensional echocardiography, American Society of Echocardiography Committee on standards, subcommittee on quantitation of two-dimensional echocardiograms. J Am Soc Echocardiogr 1989; 2: 358-367.
18. Schiller NB. Two-dimensional echocardiographic determination of left ventricular volume, systolic function, and mass. Summary and discussion of the 1989 recommendations of the American Society of Echocardiography. Circulation 1991; 84: 1280-1287.
19. Agrawal B, Berger A, Wolf K, Luft FC. Microalbuminuria screening by reagent strips predicts cardiovascular risk in hypertension. J Hypertens 1996; 14: 223-228.
20. Modan M, Halkin H, Karasik A, Lusky A. Elevated serum uric acid: a facet of hyperinsulinemia. Diabetologia 1987; 30: 713-718.
21. Kuusisto J, Mykkanen L, Pyorala K, Laakso M. Hyperinsulinemic microalbuminuria: a new risk indicator for coronary heart disease. Circulation 1995; 91: 831-837.
22. Modan M et al. Hyperinsulinemia: a link between hypertension, obesity and glucose intolerance. J Clin Invest 1985; 75: 809-817.
23. Niskanen L, Laakso M. Insulin resistance is related to albuminuria in patients with type II (non-insulin-dependent) diabetes mellitus. Metabolism 1993; 42: 1541-1545.
24. Saad MF et al. Racial differences in the relation between blood pressure and insulin resistance. N Engl J Med 1991; 324: 733-739.
25. Berry CE, Hare JM. Xanthine oxidoreductase and cardiovascular disease - molecular mechanisms and pathophysiologic implications. J Physiol 2004; 555(Part 3): 589-606.
26. Sesso HD et al. C-reactive protein and the risk of developing hypertension. JAMA 2003; 290: 2945-2951.
27. Kanellis J et al. Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen - activated protein kinase and cyclooxygenase-2. Hypertension 2003; 41: 1287-1293.
28. Di Bello V et al. Microalbuminuria, pulse pressure, left ventricular hypertrophy, and myocardial ultrasonic tissue characterization in essential hypertension. Angiology 2001; 52 175-183.
29. Dell'omo G et al. Blood pressure independent association of microalbuminuria and left ventricular hypertrophy in hypertensive men. J Intern Med 2003; 254: 76-84.
30. Ravera M et al. Microalbuminuria and subclinical cerebrovascular damage in essential hypertension. J Nephrol 2002; 15: 519-524.
31. Tsioufis C et al. Inter-relationships of microalbuminuria with the other surrogates of the atherosclerotic cardiovascular disease in hypertensive subjects. Am J Hypertens 2004; 17: 470-476.
32. Tsioufis C et al. Microalbuminuria is associated with unfavourable cardiac geometric adaptations in essential hypertensive patients. J Hum Hypertens 2002; 16: 249-254.
33. Tsioufis C et al. Relation of ambulatory blood pressure load with left ventricular geometry in untreated patients with mild-to-moderate hypertension. J Hum Hypertens 1999; 13: 677-682.
34. Tsioufis C et al. Microalbuminuria is associated with impaired arterial mechanics in essential hypertension. Am J Cardiol 2000; 86: 797-801.
35. Alderman MH, Cohen H, Madhavan S, Kivlighn S. Serum uric acid and cardiovascular events in successfully treated hypertensive patients. Hypertension 1999; 34: 144-150.
36. Staessen J. The determinants and prognostic significance of serum uric acid in elderly patients of the European Working Party on High Blood Pressure in the Elderly trial. Am J Med 1991; 90: 50S-54S.
37. Franse LV et al. Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). J Hypertens 2000; 18: 1149-1154.