Monoterpenoid oxindole alkaloid production by Uncaria tomentosa (Willd) D.C. cell suspension cultures in a stirred tank bioreactor

Biotechnology Progress

Volumn 21, Issue 3, 2005, Pages 786-792

  Trejo Tapia, Gabriela ^a,b   Cerda García Rojas, Carlos M ^a   Rodríguez Monroy, Mario ^b   Ramos Valdivia, Ana C ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMASS; BIOREACTORS; BIOTECHNOLOGY; GROWTH KINETICS; MORPHOLOGY; PLANTS (BOTANY);

CELL GROWTH; GROWTH RATE; MONOTERPENOID OXINDOLE ALKALOID (MOA); STIRRED TANK BIOREACTORS;

PLANT CELL CULTURE;

INDOLE ALKALOID; TERPENE;

ARTICLE; BIOREACTOR; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; CULTURE TECHNIQUE; CYTOLOGY; EQUIPMENT; EQUIPMENT DESIGN; EVALUATION; FLOW KINETICS; INSTRUMENTATION; ISOLATION AND PURIFICATION; METHODOLOGY; PHYSIOLOGY; PILOT STUDY; PLANT LEAF; UNCARIA TOMENTOSA;

BIOREACTORS; CAT'S CLAW; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; INDOLE ALKALOIDS; MONOTERPENES; PILOT PROJECTS; PLANT LEAVES; RHEOLOGY;

UNCARIA TOMENTOSA;

EID: 20144374949     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp049608s     Document Type: Article

References (37)

1. Obregón-Vilches, L. E. Género Uncaria: Estudios botánicos, químicos y farmacológicos de Uncaria tomentosa (Willd) DC y Uncaria guianensis. Instituto de Fitoterapia Americano: Lima, Perú, 1995; pp 12-119.
2. Laus, G.; Brössner, D.; Keplinger, K. Alkaloids of Peruvian Uncaria tomentosa. Phytochem. 1997, 45, 855-860.
3. Keplinger, K.; Laus, G.; Wurm, M.; Dierich, M. P.; Teppner, H. Uncaria tomentosa (Willd.) D.C. - Ethnomedicinal use and new pharmacological, toxicological and botanical results. J. Ethnopharmacol. 1999, 64, 23-34.
4. Laus, G. Advances in chemistry and bioactivity of the genus Uncaria. Phytother. Res. 2004, 18, 259-274.
5. Winkler, C.; Wirleitner, B.; Schroecksnadel, K.; Schennach, H.; Mur, E.; Fuchs, D. In vitro effects of two extracts and two pure alkaloid preparations of Uncaria tomentosa on peripheral blood mononuclear cells. Planta Med. 2004, 70, 205-210.
6. Verpoorte, R.; Contin, A.; Memelink, J. Biotechnology for the production of plant secondary metabolites. Phytochem. Rev. 2002, 1, 13-25.
7. Scragg, A. H.; Alan, E. J.; Leckie, F. Effect of shear on the viability of plant cell suspension. Enzyme Microb. Technol. 1997, 10, 361-367.
8. Kieran, P. M.; MacLoughlin, P. F.; Malone, D. M. Plant cell suspension cultures: some engineering considerations. J. Biotechnol. 1997, 59, 39-52.
9. Meijer, J.; ten Hoopen, H.; van-Gameren, Y.; Luyben, K.; Libbenga, K. Effects of hydrodynamic stress on the growth of plant cells in batch and continuous culture. Enzyme Microb. Technol. 1994, 16, 467-477.
10. Rodríguez-Monroy, M.; Galindo, E. Broth rheology, growth and metabolite production of Beta vulgaris suspension culture: a comparative study between cultures grown in shake flasks and in a stirred tank. Enzyme Microb. Technol. 1999, 24, 687-693.
11. Juárez, M.; Jiménez-Aparicio, A.; Gutiérrez- López, G.; Trejo-Tapia, G.; Rodríguez-Monroy, M. Broth rheology of Beta vulgaris cultures growing in an air lift bioreactor. Biochem. Eng. J. 2002, 12, 37-41.
12. Zhao, D.; Huang, Y.; Jin, Z.; Qu, W.; Lu, D. Effect of aggregate size in cell cultures of Saussurea medusa on cell growth and jaceosidin production. Plant Cell Rep. 2003, 21, 1129-1133.
13. Trejo-Tapia, G.; Jiménez-Aparicio, A.; Villarreal, M.; Rodríguez-Monroy, M. Broth rheology and morphological analysis of Solanum chrysotrichum cultures developed in a stirred tank. Biotechnol. Lett. 2001, 23, 1943-1946.
14. Chen, S. Y.; Huang, S. Y. Shear stress effects on cell growth and L-DOPA production by suspension culture of Stizolobium hasjoo cells in an agitated bioreactor. Bioprocess Eng. 2000, 22, 5-12.
15. Han, J.; Zhong, J. J. Effects of oxygen partial pressure on cell growth and gingsenoside and polysaccharide production in high-density cell cultures of Panax notoginseng. Enzyme Microb. Technol. 2003, 32, 498-503.
16. Shellard, E. J.; Phillipson, J. D.; Gupta, D. The Mitragyna species of Asia. The alkaloids from bark of Mitragyna parvifolia (Roxb) Korth and a possible biogenetic route for the oxindole alkaloids. Planta Med. 1969, 17, 146-163.
17. Verpoorte, R.; van der Heijden, R.; Moreno, P. R. H. Biosynthesis of terpenoid indole alkaloids in Catharanthus roseus cells. In The Alkaloids; Cordell, G. A., Ed: Academic Press: San Diego, 1997; Vol. 49, pp 221-299.
18. Luna-Palencia, G. R.; Cerda-García-Rojas, C. M.; Rodríguez-Monroy, M.; Ramos-Valdivia, A. C. Influence of auxins and sucrose in monoterpenoid oxindole alkaloid production by Uncaria tomentosa cell suspension cultures. Biotechnol. Prog. 2005, 21, 198-204.
19. Katoh, K.; Ohta, Y.; Hirose, Y.; Iwamura, T. Photoautotrophic growth of Mercanthia polymorpha L. cells in suspension culture. Planta 1979, 144, 509-510.
20. Contin, A.; van der Heijden, R.; Lefeber, A. W.; Verpoorte, R. The iridoid glucoside secologanin is derived from the novel triose phosphate/pyruvate pathway in a Catharanthus cell culture. FEBS Lett. 1998, 434, 413-416.
21. Luna-Palencia, G. R. Producción de alcaloides indolterpé nicos por cultivo de células de Uncaria tomentosa. Ms. Sc. thesis. CINVESTAV-IPN, Mexico City, 2002.
22. Murashige, T.; Skoog, F. A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant. 1962, 15, 473-497.
23. Halhoul, M. N.; Kleinberg, I. Differential determination of glucose and fructose, and glucose- and fructose-yielding substances with enthrone. Anal. Biochem. 1972, 50, 337-343.
24. Trejo-Tapia, G.; Hernández-Trujillo, R.; Trejo-Espino, J. L.; Jiménez-Aparicio, A.; Rodríguez-Monroy, M. Analysis of morphological characteristics of Solanum chrysotrichum cell suspension cultures. World J. Microbiol. Biotechnnol. 2003, 19, 929-932.
25. Smith, A.; Reider, M.; Fletcher, J. Relationship between vital staining and subculture growth during the senescence of plant tissue culture. Plant Physiol. 1982, 70, 1228-1230.
26. Doran, P. Design of mixing systems for plant cell suspensions in stirred bioreactor. Biotechnol. Prog. 1999, 15, 319-335.
27. Sudha, G.; Ravishankar, G. A. Involvement and interaction of various signaling compounds on the plant metabolic events during defense, resistance to stress factors, formation of secondary metabolites and their molecular aspects. Plant Cell Tiss. Organ Cult. 2002, 71, 181-212.
28. Gantet, P.; Imbault, N.; Thiersault, M.; Doireau, P. Necessity of a functional octadecanoic pathway for indole alkaloid synthesis by Catharanthus roseus cell suspensions cultured in an auxin-starved medium. Plant Cell Physiol. 1998, 39, 220-225.
29. 2+ influx and the oxidative burst. Plant Sci. 2001, 161, 423-431.
30. Merillon, J. M.; Rideau, M.; Chenieux, J. C. Influence of sucrose on levels of ajmalicine, serpentine, and tryptamine in Catharanthus roseus cells in vitro. Planta Med. 1984, 50, 497-502.
31. Morris, P. Regulation product synthesis in cell cultures of Catharanthus roseus. II. Comparison of production media. Planta Med. 1986, 52, 121-126.
32. Blom, T. J. M.; Sierra, M.; van Vliet, T. B.; Franke-van Dijk, M. E. I.; de Koning, P.; van Iren, F.; Verpoorte, R.; Libbenga, K. R. Uptake and accumulation of ajmalicine into isolated vacuoles of cultured cells of Catharanthus roseus (L.) G. Don. and its conversion into serpentine. Planta 1991, 183, 170-177.
33. Collu, G.; García, A. A.; van der Heijden, R.; Verpoorte, R. Activity of the cytochrome P450 enzyme geraniol 10-hydroxylase and alkaloid production in plant cell cultures. Plant Sci. 2002, 162, 165-172.
34. Legendre, L.; Rueter, S.; Heinstein, P. F.; Low, P. S. Characterization of the oligogalacturonide-induced oxidative burst in cultured soybean (Glycine max) cells. Plant Physiol. 1993, 102, 233-240.
35. Yahraus, T.; Chandra, S.; Legendre, L.; Low, P. S. Evidence for a mechanically induced oxidative burst. Plant Physiol. 1995, 109, 1259-1266.
36. Cazalé, A. C.; Rouet-Mayer, M. A.; Barbier-Brygoo, H.; Mathieu, Y.; Laurière, C. Oxidative burst and hypoosmotic stress in tobacco cell suspensions. Plant Physiol. 1998, 116, 659-669.
37. Schopfer, P.; Liszkay, A.; Bechtold, M.; Frahry, G.; Wagner, A. Evidence that hydroxyl radicals mediate auxin-induced extension growth. Planta 2002, 214, 821-828.