Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases

Biochemistry

Volumn 44, Issue 22, 2005, Pages 8022-8029

  Ho, Kwok Ki ^a   Allali Hassani, Abdellah ^a   Hurley, Thomas D ^b   Weiner, Henry ^a  

^a PURDUE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ALDEHYDES; DISSOCIATION; ENZYMES; MAGNESIUM PRINTING PLATES; REACTION KINETICS;

CYTOSOL; ISOZYMES; MITOCHONDRIA; NUCLEOPHILICITY;

POSITIVE IONS;

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CYSTEINE; ESTERASE; ISOENZYME; MAGNESIUM ION; MITOCHONDRIAL ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; ACETALDEHYDE; ALDH2 PROTEIN, HUMAN; CHLOROACETALDEHYDE; DIVALENT CATION; DRUG DERIVATIVE; MAGNESIUM; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ACYLATION; ARTICLE; COENZYME; CYTOSOL; DEACYLATION; DISSOCIATION; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME STRUCTURE; HUMAN; KINETICS; MITOCHONDRION; PRIORITY JOURNAL; THREE DIMENSIONAL IMAGING; CHEMISTRY; COMPARATIVE STUDY; DEUTERIUM HYDROGEN EXCHANGE; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; LIVER; METABOLISM;

MAMMALIA;

ACETALDEHYDE; ACYLATION; ALDEHYDE DEHYDROGENASE; CATIONS, DIVALENT; CYTOSOL; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; ISOENZYMES; KINETICS; LIVER; MAGNESIUM; MITOCHONDRIA; NAD; SUBSTRATE SPECIFICITY;

EID: 20144370544     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050038u     Document Type: Article

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