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Volumn 11, Issue 3, 2005, Pages 251-260

Longitudinal single-cell cytokine responses reveal recurrent autoimmune myelin reactivity in relapsing-remitting multiple sclerosis patients

Author keywords

ELISPOT; IFN ; IL 10; Longitudinal cytokine reactivity; Multiple sclerosis; Myelin basic protein; Proteolipid protein

Indexed keywords

AMINO ACID; BETA1A INTERFERON; CYTOKINE; GADOLINIUM; MYELIN; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN;

EID: 20144364415     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1191/1352458505ms1165oa     Document Type: Article
Times cited : (5)

References (36)
  • 1
    • 0024245664 scopus 로고
    • On the immunopathology of plaque development and repair in multiple sclerosis
    • Raine CS, Scheinberg LC. On the immunopathology of plaque development and repair in multiple sclerosis. J Neuroimmunol 1988; 20: 189-201.
    • (1988) J. Neuroimmunol. , vol.20 , pp. 189-201
    • Raine, C.S.1    Scheinberg, L.C.2
  • 3
    • 0025155486 scopus 로고
    • Myelin autoreactivity in multiple sclerosis: Recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors
    • Pette M, Fujita K, Wilkinson D, Altmann DM, Trowsdale J, Giegerich G et al. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. Proc Natl Acad Sci USA 1990; 87: 7968-72.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7968-7972
    • Pette, M.1    Fujita, K.2    Wilkinson, D.3    Altmann, D.M.4    Trowsdale, J.5    Giegerich, G.6
  • 4
    • 0027389119 scopus 로고
    • Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients
    • Valli A, Sette A, Kappos L, Oseroff C, Sidney J, Miescher G et al. Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients. J Clin Invest 1993; 91: 616-28.
    • (1993) J. Clin. Invest. , vol.91 , pp. 616-628
    • Valli, A.1    Sette, A.2    Kappos, L.3    Oseroff, C.4    Sidney, J.5    Miescher, G.6
  • 5
    • 0025138302 scopus 로고
    • T cells responsive to myelin basic protein in patients with multiple sclerosis
    • Allegretta M, Nicklas JA, Sriram S, Albertini RJ. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 1990; 247: 718-21.
    • (1990) Science , vol.247 , pp. 718-721
    • Allegretta, M.1    Nicklas, J.A.2    Sriram, S.3    Albertini, R.J.4
  • 6
    • 0022447413 scopus 로고
    • Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis
    • Johnson D, Hafler DA, Fallis RJ, Lees MB, Brady RO, Quarles RH et al. Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis. J Neuroimmunol 1986; 13: 99-108.
    • (1986) J. Neuroimmunol. , vol.13 , pp. 99-108
    • Johnson, D.1    Hafler, D.A.2    Fallis, R.J.3    Lees, M.B.4    Brady, R.O.5    Quarles, R.H.6
  • 7
    • 0030697438 scopus 로고    scopus 로고
    • Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: Reactivity to the extracellular domain of MOG is directed against three main regions
    • Kerlero DR, Hoffman M, Mendel I, Yust I, Kaye J, Bakimer R et al. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur J Immunol 1997; 27: 3059-69.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 3059-3069
    • Kerlero, D.R.1    Hoffman, M.2    Mendel, I.3    Yust, I.4    Kaye, J.5    Bakimer, R.6
  • 8
    • 0026664422 scopus 로고
    • Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
    • Lehmann PV, Forsthuber T, Miller A, Sercarz EE. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 1992; 358: 155-57.
    • (1992) Nature , vol.358 , pp. 155-157
    • Lehmann, P.V.1    Forsthuber, T.2    Miller, A.3    Sercarz, E.E.4
  • 9
    • 0030899404 scopus 로고    scopus 로고
    • Diversity and plasticity of self recognition during the development of multiple sclerosis
    • Tuohy VK, Yu M, Weinstock-Guttman B, Kinkel RP. Diversity and plasticity of self recognition during the development of multiple sclerosis. J Clin Invest 1997; 99: 1682-90.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1682-1690
    • Tuohy, V.K.1    Yu, M.2    Weinstock-Guttman, B.3    Kinkel, R.P.4
  • 11
    • 0025735625 scopus 로고
    • T cell sensitization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis
    • Perry LL, Barzaga-Gilbert E, Trotter JL. T cell sensitization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis. J Neuroimmunol 1991; 33: 7-15.
    • (1991) J. Neuroimmunol. , vol.33 , pp. 7-15
    • Perry, L.L.1    Barzaga-Gilbert, E.2    Trotter, J.L.3
  • 12
    • 0027027601 scopus 로고
    • Antigen-specific tolerance as a therapy for experimental autoimmune encephalomyelitis
    • Miller SD, Tan LJ, Pope L, McRae BL, Karpus WJ. Antigen-specific tolerance as a therapy for experimental autoimmune encephalomyelitis. Int Rev Immunol 1992; 9: 203-22.
    • (1992) Int. Rev. Immunol. , vol.9 , pp. 203-222
    • Miller, S.D.1    Tan, L.J.2    Pope, L.3    McRae, B.L.4    Karpus, W.J.5
  • 14
    • 0017892793 scopus 로고
    • Cell-mediated immunity to measles, myelin basic protein, and central nervous system extract in multiple sclerosis. A longitudinal study employing direct buffy coat migration inhibition assays
    • Lisak RP, Zweiman B, Waters D, Korpowski H, Pleasure DE. Cell-mediated immunity to measles, myelin basic protein, and central nervous system extract in multiple sclerosis. A longitudinal study employing direct buffy coat migration inhibition assays. Neurology 1978; 28: 798-803.
    • (1978) Neurology , vol.28 , pp. 798-803
    • Lisak, R.P.1    Zweiman, B.2    Waters, D.3    Korpowski, H.4    Pleasure, D.E.5
  • 16
    • 0034326642 scopus 로고    scopus 로고
    • Surges of increased T cell reactivity to an encephalitogenic region of myelin proteolipid protein occur more often in patients with multiple sclerosis than in healthy subjects
    • Pender MP, Csurhes PA, Greer JM, Mowat PD, Henderson RD, Cameron KD et al. Surges of increased T cell reactivity to an encephalitogenic region of myelin proteolipid protein occur more often in patients with multiple sclerosis than in healthy subjects. J Immunol 2000; 165: 5322-31.
    • (2000) J. Immunol. , vol.165 , pp. 5322-5331
    • Pender, M.P.1    Csurhes, P.A.2    Greer, J.M.3    Mowat, P.D.4    Henderson, R.D.5    Cameron, K.D.6
  • 17
    • 0036096668 scopus 로고    scopus 로고
    • Longitudinal study of antimyelin T-cell reactivity in relapsing-remitting multiple sclerosis: Association with clinical and MRI activity
    • Hellings N, Gelin G, Medaer R, Bruckers L, Palmers Y, Raus J et al. Longitudinal study of antimyelin T-cell reactivity in relapsing-remitting multiple sclerosis: association with clinical and MRI activity. J Neuroimmunol 2002; 126: 143-60.
    • (2002) J. Neuroimmunol. , vol.126 , pp. 143-160
    • Hellings, N.1    Gelin, G.2    Medaer, R.3    Bruckers, L.4    Palmers, Y.5    Raus, J.6
  • 18
    • 0037376779 scopus 로고    scopus 로고
    • A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis
    • Arbour N, Holz A, Sipe JC, Naniche D, Romine JS, Zyroff J et al. A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis. J Neuroimmunol 2003; 137: 197-209.
    • (2003) J. Neuroimmunol. , vol.137 , pp. 197-209
    • Arbour, N.1    Holz, A.2    Sipe, J.C.3    Naniche, D.4    Romine, J.S.5    Zyroff, J.6
  • 19
    • 0033544320 scopus 로고    scopus 로고
    • Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS
    • Multiple Sclerosis Collaborative Research Group
    • Rudick RA, Fisher E, Lee JC, Simon J, Jacobs L. Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS. Multiple Sclerosis Collaborative Research Group. Neurology 1999; 53: 1698-704.
    • (1999) Neurology , vol.53 , pp. 1698-1704
    • Rudick, R.A.1    Fisher, E.2    Lee, J.C.3    Simon, J.4    Jacobs, L.5
  • 21
    • 0034254825 scopus 로고    scopus 로고
    • Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production
    • Pelfrey CM, Rudick RA, Cotleur AC, Lee JC, Tary-Lehmann M, Lehmann PV. Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production. J Immunol 2000; 165: 1641-51.
    • (2000) J. Immunol. , vol.165 , pp. 1641-1651
    • Pelfrey, C.M.1    Rudick, R.A.2    Cotleur, A.C.3    Lee, J.C.4    Tary-Lehmann, M.5    Lehmann, P.V.6
  • 22
    • 0142043832 scopus 로고    scopus 로고
    • Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression
    • Moldovan IR, Rudick RA, Cotleur AC, Born SE, Lee JC, Karafa MT, Pelfrey CM. Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression. J Neuroimmunol 2003; 141: 132-40.
    • (2003) J. Neuroimmunol. , vol.141 , pp. 132-140
    • Moldovan, I.R.1    Rudick, R.A.2    Cotleur, A.C.3    Born, S.E.4    Lee, J.C.5    Karafa, M.T.6    Pelfrey, C.M.7
  • 23
    • 0027362631 scopus 로고
    • Identification of a novel T cell epitope of human proteolipid protein (residues 40-60) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients
    • Pelfrey CM, Trotter JL, Tranquill LR, McFarland HF. Identification of a novel T cell epitope of human proteolipid protein (residues 40-60) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients. J Neuroimmunol 1993; 46: 33-42.
    • (1993) J. Neuroimmunol. , vol.46 , pp. 33-42
    • Pelfrey, C.M.1    Trotter, J.L.2    Tranquill, L.R.3    McFarland, H.F.4
  • 24
    • 0027978106 scopus 로고
    • Identification of a second T cell epitope of human proteolipid protein (residues 89-106) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients
    • Pelfrey CM, Trotter JL, Tranquill LR, McFarland HF. Identification of a second T cell epitope of human proteolipid protein (residues 89-106) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients. J Neuroimmunol 1994; 53: 153-61.
    • (1994) J. Neuroimmunol. , vol.53 , pp. 153-161
    • Pelfrey, C.M.1    Trotter, J.L.2    Tranquill, L.R.3    McFarland, H.F.4
  • 25
    • 0028070413 scopus 로고
    • Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: A review
    • Tuohy VK. Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: a review. Neurochem Res 1994; 19: 935-44.
    • (1994) Neurochem. Res. , vol.19 , pp. 935-944
    • Tuohy, V.K.1
  • 26
    • 0030861738 scopus 로고    scopus 로고
    • Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis
    • Greer JM, Csurhes PA, Cameron KD, McCombe PA, Good MF, Pender MP. Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis. Brain 1997; 120: 1447-60.
    • (1997) Brain , vol.120 , pp. 1447-1460
    • Greer, J.M.1    Csurhes, P.A.2    Cameron, K.D.3    McCombe, P.A.4    Good, M.F.5    Pender, M.P.6
  • 27
    • 0020551984 scopus 로고
    • Isolation of myelin basic protein-reactive T-cell lines from normal human blood
    • Burns J, Rosenzweig A, Zweiman B, Lisak RP. Isolation of myelin basic protein-reactive T-cell lines from normal human blood. Cell Immunol 1983; 81: 435-40.
    • (1983) Cell Immunol. , vol.81 , pp. 435-440
    • Burns, J.1    Rosenzweig, A.2    Zweiman, B.3    Lisak, R.P.4
  • 28
    • 0033976207 scopus 로고    scopus 로고
    • Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: Epitope spreading versus clonal persistence
    • Goebels N, Hofstetter H, Schmidt S, Brunner C, Wekerle H, Hohlfeld R. Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: epitope spreading versus clonal persistence. Brain 2000; 123: 508-18.
    • (2000) Brain , vol.123 , pp. 508-518
    • Goebels, N.1    Hofstetter, H.2    Schmidt, S.3    Brunner, C.4    Wekerle, H.5    Hohlfeld, R.6
  • 29
    • 0035254476 scopus 로고    scopus 로고
    • T-cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls
    • Hellings N, Baree M, Verhoeven C, D'hooghe MB, Medaer R, Bernard CC et al. T-cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls. J Neurosci Res 2001; 63: 290-302.
    • (2001) J. Neurosci. Res. , vol.63 , pp. 290-302
    • Hellings, N.1    Baree, M.2    Verhoeven, C.3    D'hooghe, M.B.4    Medaer, R.5    Bernard, C.C.6
  • 30
    • 0037334286 scopus 로고    scopus 로고
    • Time course of T-cell responses to MOG and MBP in patients with clinically isolated syndromes
    • Correale J, de los Milagros Bassani Molinas. Time course of T-cell responses to MOG and MBP in patients with clinically isolated syndromes. J Neuroimmunol 2003; 136: 162-71.
    • (2003) J. Neuroimmunol. , vol.136 , pp. 162-171
    • Correale, J.1    de los Bassani Molinas, M.2
  • 32
    • 0023678901 scopus 로고
    • In vivo competition between self peptides and foreign antigens in T-cell activation
    • Adorini L, Muller S, Cardinaux F, Lehmann PV, Falcioni F, Nagy ZA. In vivo competition between self peptides and foreign antigens in T-cell activation. Nature 1988; 334: 623-25.
    • (1988) Nature , vol.334 , pp. 623-625
    • Adorini, L.1    Muller, S.2    Cardinaux, F.3    Lehmann, P.V.4    Falcioni, F.5    Nagy, Z.A.6
  • 33
    • 0026080797 scopus 로고
    • T cell determinant structure: Cores and determinant envelopes in three mouse major histocompatibility complex haplotypes
    • Gammon G, Geysen HM, Apple RJ, Pickett E, Palmer M, Ametani A et al. T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes. J Exp Med 1991; 173: 609-17.
    • (1991) J. Exp. Med. , vol.173 , pp. 609-617
    • Gammon, G.1    Geysen, H.M.2    Apple, R.J.3    Pickett, E.4    Palmer, M.5    Ametani, A.6
  • 34
    • 0032526853 scopus 로고    scopus 로고
    • Endogenous myelin basic protein inactivates the high avidity T cell repertoire
    • Targoni OS, Lehmann PV. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J Exp Med 1998; 187: 2055-63.
    • (1998) J. Exp. Med. , vol.187 , pp. 2055-2063
    • Targoni, O.S.1    Lehmann, P.V.2
  • 35
    • 0031726374 scopus 로고    scopus 로고
    • The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis
    • Tuohy VK, Yu M, Yin L, Kawczak JA, Johnson JM, Mathisen PM et al. The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Rev 1998; 164: 93-100.
    • (1998) Immunol. Rev. , vol.164 , pp. 93-100
    • Tuohy, V.K.1    Yu, M.2    Yin, L.3    Kawczak, J.A.4    Johnson, J.M.5    Mathisen, P.M.6
  • 36
    • 0032765901 scopus 로고    scopus 로고
    • Regression and spreading of self-recognition during the development of autoimmune demyelinating disease
    • Tuohy VK, Yu M, Yin L, Kawczak JA, Kinkel PR. Regression and spreading of self-recognition during the development of autoimmune demyelinating disease. J Autoimmun 1999; 13: 11-20.
    • (1999) J. Autoimmun. , vol.13 , pp. 11-20
    • Tuohy, V.K.1    Yu, M.2    Yin, L.3    Kawczak, J.A.4    Kinkel, P.R.5


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