Acute haemodynamic effects of IL-6 treatment in vivo: Involvement of vagus nerve in NO-mediated negative inotropism

Cytokine

Volumn 30, Issue 5, 2005, Pages 236-242

  Comini, Laura ^a   Pasini, Evasio ^a   Bachetti, Tiziana ^a   Dreano, Michel ^b   Garotta, Gianni ^b   Ferrari, Roberto ^c  

^a IRCCS   (Italy)

^b Serono International SA   (Switzerland)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

Haemodynamics; Interleukin 6; Nitric oxide; Vagus nerve

Indexed keywords

INTERLEUKIN 6; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA PRESSURE; ARTICLE; ASSISTED VENTILATION; CONTROLLED STUDY; DATA ANALYSIS; HEART LEFT VENTRICLE; HEMODYNAMICS; IN VIVO STUDY; INOTROPISM; MALE; NERVE LIGATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; SYSTOLIC BLOOD PRESSURE; VAGUS NERVE;

ANIMALS; BLOOD PRESSURE; BLOTTING, WESTERN; ENZYME INHIBITORS; HEART; HEMODYNAMIC PROCESSES; INTERLEUKIN-6; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; VAGUS NERVE;

EID: 20144363219     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2005.01.009     Document Type: Article

References (22)

1. M.A. Munger, B. Johnson, I.J. Amber, K.S. Callahan, and E.M. Gilbert Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy Am J Cardiol 77 1996 723 727
2. P. Aukrust, T. Ueland, E. Lien, K. Bendtzen, F. Müller, and A.K. Andreassen Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy Am J Cardiol 83 1999 376 382
3. G. Plenz, Z.F. Song, T.D. Tjan, C. Koenig, H.A. Baba, and M. Erren Activation of the cardiac interleukin-6 system in advanced heart failure Eur J Heart Fail 3 4 2001 415 421
4. H.G. Elken, J.K. Damas, A. Yndestad, V. Bjerkell, H. Aass, and S. Simonsen Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure Eur J Clin Invest 31 5 2001 389 397
5. M.S. Finkel, C.V. Oddis, T.D. Jacob, S.C. Watkins, B.G. Hattler, and R.L. Simmons Negative inotropic effects by cytokines on the heart mediated by nitric oxide Science 257 1992 387 389
6. i and cell contraction in cultured chick ventricular myocytes Circ Res 75 1994 285 295
7. X.W. Yu, R.H. Kennedy, and S.J. Liu JAK2/STAT3, not ERK1/2, pathway mediates interleukin-6-elicited inducible NOS activation and decrease in contractility in adult ventricular myocytes J Biol Chem 278 18 2003 16304 16309
8. K.Y. Xu, D.L. Huso, T.M. Dawson, D.S. Bredt, and L.C. Becker Nitric oxide synthase in cardiac sarcoplasmic reticulum Proc Natl Acad Sci U S A 96 1999 657 662
9. V.J. Massari, L.W. Dickerson, A.L. Gray, J.M. Lauenstein, K.J. Blinder, and J.T. Newsome Neural control of left ventricular contractility in the dog heart: synaptic interactions of negative inotropic vagal preganglionic neurons in the nucleus ambiguous with tyrosine hydroxylase immunoreactive terminals Brain Res 802 1998 205 220
10. K. Conlon, and Kidd Cecil Neuronal nitric oxide facilitates vagal chronotropic and dromotropic actions on the heart J Auton Nerv Syst 75 1999 136 146
11. C.E. Sears, S.M. Bryant, E.A. Ashley, C.A. Lygate, S. Rakovic, and H.L. Wallis Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling Circ Res 92 5 2003 e52 e59
12. T. Bachetti, E. Pasini, E. Clini, G. Cremona, and R. Ferrari High-dose heparin impairs nitric oxide pathway and vasomotion in rats Circulation 99 1999 2861 2863
13. P.K. Moore, P. Wallace, Z. Gaffen, S.L. Hart, and R.C. Babbedge Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects Br J Pharmacol 110 1993 219 224
14. L. Comini, T. Bachetti, G. Gaia, E. Pasini, L. Agnoletti, and P. Pepi Aorta and skeletal muscle no-synthase expression in experimental heart failure J Mol Cell Cardiol 28 1996 2241 2248
15. T. Bachetti, E. Pasini, H. Suzuki, and R. Ferrari Species-specific modulation of the nitric oxide pathway after acute experimentally induced endotoxemia Crit Care Med 31 5 2003 1 6
16. R. Ferrari, A. Cargnoni, P. Bernocchi, E. Pasini, S. Curello, and C. Ceconi Metabolic adaptation during a sequence of no-flow and low-flow ischaemia: a possible trigger for hibernation Circulation 94 1996 2587 2596
17. I. Hamanaka, Y. Miyamoto, M. Harada, E. Ogawa, N. Kajiyama, and N. Takahashi Effect of cardiotrophin-1 on haemodynamics and endocrine function of the heart Am J Physiol 278 2000 H388 H396
18. I.L. Buxton, D.J. Cheek, D. Eckman, D.P. Westfall, K.M. Sanders, and K.D. Keef NG-nitro l-arginine methyl-ester and other alkyl ester of arginine are muscarinic receptor antagonists Circ Res 72 1993 387 395
19. B. Hellmich, and L. Gyermek NG-nitro l-arginine methyl-ester: a muscarinic receptor antagonist? Fundam Clin Pharmacol 11 1997 305 314
20. M. Saito, K. Yoshida, M. Hibi, T. Taga, and T. Kishimoto Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo J Immunol 148 1992 4066 4071
21. R.M. Mohan, D.A. Heaton, E.J.F. Danson, S.P.R. Krishnan, K.M. Channon, and D.J. Paterson Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function Circ Res 91 2002 1089 1091
22. P.J. Gatti, T.A. Johnson, J. McKenzie, J.-M. Lauenstein, A. Gray, and V.J. Massari Vagal control of left ventricular contractility is selectively mediated by a cranioventricular intracardiac ganglion in the cat J Auton Nerv Syst 66 3 1997 138 144