Tumor growth and immune function in mice during hind-limb unloading

Aviation Space and Environmental Medicine

Volumn 76, Issue 6, 2005, Pages 536-540

  Lee, Erica H ^a   Ding, Wanhong ^a   Kulkarni, Anil D ^b   Granstein, Richard D ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Animal model; Immunology; Mouse

Indexed keywords

CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER; CANCER RISK; CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; EXPERIMENTAL MODEL; FEMALE; GENE MUTATION; HINDLIMB; HINDLIMB UNLOADING MODEL; HOUSING; IMMUNE RESPONSE; MICROGRAVITY; MOUSE; NONHUMAN; SCID MOUSE; SPACE FLIGHT; TUMOR GROWTH; TUMOR VOLUME; WEIGHT BEARING;

NASA DISCIPLINE CELL BIOTECHNOLOGY; NON-NASA CENTER;

ANIMALS; DISEASE PROGRESSION; FEMALE; HINDLIMB; HINDLIMB SUSPENSION; MICE; MICE, INBRED STRAINS; MODELS, ANIMAL; NEOPLASMS; SPACE FLIGHT; TIME FACTORS; WEIGHT-BEARING; WEIGHTLESSNESS;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE; RODENTIA;

EID: 20044395988     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Belay T, Aviles H, Vance M, et al. Effects of the hindlimb-unloading model of spaceflight conditions on resistance of mice to infection with Klebsiella pneumoniae. J Allergy Clin Immunol 2002; 110:262-8.
2. Caren L, Mandel A, Nunes J. Effect of simulated weightlessness on the immune system in rats. Aviat Space Environ Med 1980; 51:251-5.
3. Chapes SK, Mastro AM, Sonnenfeld G, Berry WD. Antiorthostatic suspension as a model for the effects of spaceflight on the immune system. J Leukoc Biol 1993; 54:227-35.
4. Cogoli A, Tschopp A, Fuchs-Bislin P. Cell sensitivity to gravity. Science 1984; 225:228-30.
5. Cogoli A. The effect of hypogravity and hypergravity on cells of the immune system. J Leukoc Biol 1993; 54:259-68.
6. Committee on Space Biology and Medicine Space Studies Board, Commission on Physical Sciences, Mathematics, and Applications. A strategy for research in space biology and medicine in the new century. Washington, DC: National Academy Press; 1998.
7. Dorschkind K. The severe combined immunodeficient (SCID) mouse. In: Rihova B, Vetvicka V, eds. Immunologic disorders in mice. Boca Raton, FL: CRC Press; 1991:1-21.
8. Fujimoto S, Greene M, Sehon AH. Immunosuppressor T cells in tumor bearing host. Immunol Commun 1975; 4:201-17.
9. Gould CL, Sonnenfeld G. Enhancement of viral pathogenesis in mice maintained in an antiorthostatic suspension model: coordination with effects on interferon production. J Biol Regul Homeost Agents 1987; 1:33-6.
10. Grabbe S, Bruvers S, Gallo RL, et al. Tumor antigen presentation by murine epidermal cells. J Immunol 1991; 146:3656-61.
11. Green M, Webber S. Posttransplantation lymphoproliferative disorders. Pediatr Clin North Am 2003; 50:1471-91.
12. Hamm PB, Billica RD, Johnson GS, et al. Risk of cancer mortality among the Longitudinal Study of Astronaut Health (LSAH) participants. Aviat Space Environ Med 1998; 69:142-4.
13. Hung K, Hayaski R, Lafond-Walker A, et al. The central role of CD4(+) T cells in the antitumor immune response. J Exp Med 1998; 188:2357-68.
14. Iwakabe K, Shimada M, Ohta A, et al. The restraint stress drives a shift in Th1/Th2 balance toward Th2-dominant immunity in mice. Immunol Lett 1998; 62:39-43.
15. Li T, Harada M, Tamada K, et al. Repeated restraint stress impairs the antitumor T cell response through its suppressive effect on Th1-type CD4+ T cells. Anticancer Res 1997; 17:4259-68.
16. Macho L, Kvetnansky R, Fickova M, et al. Effects of exposure to spaceflight on endocrine regulations in experimental animals. Endocrine Reg 2001; 35:101-14.
17. Meehan R, Whitson P, Sams C. The role of psychoneuroendocrine factors on spaceflight-induced immunological alterations. J Leukoc Biol 1993; 54:236-44.
18. Miller ES, Sonnenfeld G. Influence of antiorthostatic suspension on resistance to murine Listeria monocytogenes infection. J Leukoc Biol 1994; 55:371-8.
19. Moore FD. Radiation burdens for humans on prolonged exomagnetospheric voyages. FASEB J 1992; 26:2338-43.
20. Nash P, Bour B, Mastro A. Effect of hindlimb suspension simulation of microgravity on in vitro immunological responses. Exp Cell Res 1991; 195:353-60.
21. Padgett DA, Glaser R. How stress influences the immune response. Trends Immunol 2003; 24:444-8.
22. Pecaut MJ, Simske SJ, Fleshner M. Spaceflight induces changes in splenocyte subpopulations: effectiveness of ground-based models. Am J Physiol Regul Integ Comp Physiol 2000; 279: R2072-8.
23. Posevitz V, Vizier C, Benyhe S, et al. Restraint stress and antitumor immune response in mice. Acta Biol Hung 2003; 54:167-76.
24. Randle HW. The historical link between solid-organ transplantation, immunosuppression and skin cancer. Dermatol Surg 2004; 30:595-7.
25. Schatten S, Granstein RD, Drebin JA, Greene MI. Suppressor T cells and the immune response to rumors. Crit Rev Immunol 1984; 4:335-79.
26. Shultz LD. Immunological mutants of the mouse. Am J Anat 1991; 191:303-11.
27. Sonnenfeld G. The immune system in space and microgravity. Med Sci Sports Exerc 2002; 34:2021-7.
28. Sonnenfeld G, Miller ES. The role of cytokines in immune changes induced by spaceflight. J Leukoc Biol 1993; 54:253-8.
29. Stowe RP, Pierson DL, Barrett AD. Elevated stress hormone levels relate to Epstein-Barr virus reactivation in astronauts. Psychosom Med 2001; 63:891-5.
30. Taylor GR. Overview of spaceflight immunology studies. J Leukoc Biol 1993; 54:179-88.
31. Taylor GR, Janney RP. In vivo testing confirms a blunting of the human cell-mediated immune mechanism during space flight. J Leukoc Biol 1992; 51:129-32.
32. Wen XL, Yang GH, Wang T, Hu P. Effects of simulated weightlessness on T cell subpopulations and activity of IL-2 and IL-6 in mice. Space Med Med Eng (Beijing) 2001; 14:60-2.