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Volumn 118, Issue 4, 1996, Pages 1058-1064

Further investigation into the signal transduction mechanism of the 5-HT4-like receptor in the circular smooth muscle of human colon

Author keywords

5 HT4 receptors; 5 hydroxytryptamine (serotonin); Adenylyl cyclase inhibitor; Cyclic AMP; GR 113808; Human colon; Phosphodiesterase inhibitor; Protein kinase inhibitor

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 9 (TETRAHYDRO 2 FURYL)ADENINE; CYCLIC AMP; DAU 6236; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; LYASE INHIBITOR; METHYSERGIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; ONDANSETRON; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; SEROTONIN 4 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

EID: 0029785502     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15506.x     Document Type: Article
Times cited : (31)

References (50)
  • 1
    • 0024253227 scopus 로고
    • Multiple isozymes of cyclic nucleotide phosphodiesterase
    • BEAVO, J.A. (1988). Multiple isozymes of cyclic nucleotide phosphodiesterase. Adv. Second Messenger Phosphoprotein Res., 22, 1-38.
    • (1988) Adv. Second Messenger Phosphoprotein Res. , vol.22 , pp. 1-38
    • Beavo, J.A.1
  • 2
    • 9344224021 scopus 로고
    • Cyclic AMP-dependent protein phosphorylation
    • BEAVO, J.A. & MUMBY, M.C. (1982). Cyclic AMP-dependent protein phosphorylation. Handb. Exp. Pharmakol., 581, 363-392.
    • (1982) Handb. Exp. Pharmakol. , vol.581 , pp. 363-392
    • Beavo, J.A.1    Mumby, M.C.2
  • 3
    • 0025215525 scopus 로고
    • Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors
    • BEAVO, J.A. & REIFSNYDER, D.H. (1990). Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol. Sci., 11, 150-155.
    • (1990) Trends Pharmacol. Sci. , vol.11 , pp. 150-155
    • Beavo, J.A.1    Reifsnyder, D.H.2
  • 4
    • 77956929978 scopus 로고
    • Cyclic nucleotide-dependent protein kinases
    • ed. Boyer, P.D. & Krebs, E.G., New York: Academic Press
    • BEEBE, S.J. & CORBIN, J.D. (1986). Cyclic nucleotide-dependent protein kinases. In The Enzymes, vol. XVII. ed. Boyer, P.D. & Krebs, E.G., pp. 43-111. New York: Academic Press.
    • (1986) The Enzymes , vol.17 , pp. 43-111
    • Beebe, S.J.1    Corbin, J.D.2
  • 5
    • 0025264053 scopus 로고
    • 4) receptors positively coupled to adenylyl cyclase in adult guinea-pig hippocampal membranes; Effect of substituted benzamide derivatives
    • 4) receptors positively coupled to adenylyl cyclase in adult guinea-pig hippocampal membranes; Effect of substituted benzamide derivatives. Mol. Pharmacol., 37, 408-411.
    • (1990) Mol. Pharmacol. , vol.37 , pp. 408-411
    • Bockaert, J.1    Sebben, M.2    Dumuis, A.3
  • 6
    • 0017184389 scopus 로고
    • A rapid sensitive method for quantitation of microgram quantities of protein utilising the principle of protein-dye binding
    • BRADFORD, M.M. (1976). A rapid sensitive method for quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 7
    • 0029024923 scopus 로고
    • Characterization of post-junctional 5-hydroxytryptamine (5-HT) receptors mediating relaxation of guinea-pig isolated ileum
    • CARTER, D., CHAMPNEY, M., HWANG, B. & EGLEN, R.M. (1995). Characterization of post-junctional 5-hydroxytryptamine (5-HT) receptors mediating relaxation of guinea-pig isolated ileum. Eur. J. Pharmacol., 280, 243.
    • (1995) Eur. J. Pharmacol. , vol.280 , pp. 243
    • Carter, D.1    Champney, M.2    Hwang, B.3    Eglen, R.M.4
  • 8
    • 0015861774 scopus 로고
    • Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (IC50) of an enzymatic reaction
    • CHENG, Y. & PRUSOFF, W.H. (1973). Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (IC50) of an enzymatic reaction. Biochem. Pharmacol., 22, 3099-3108.
    • (1973) Biochem. Pharmacol. , vol.22 , pp. 3099-3108
    • Cheng, Y.1    Prusoff, W.H.2
  • 9
    • 0025248571 scopus 로고
    • Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells
    • CHIJIWA, T., MISHIMA, A., HAGIWARA, M., SANO, M., HAYASHI, K., INOUE, T., NAITO, K., TOSHIOKA, T. & HIDAKA, H. (1989). Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J. Biol. Chem., 265, 5267-5272.
    • (1989) J. Biol. Chem. , vol.265 , pp. 5267-5272
    • Chijiwa, T.1    Mishima, A.2    Hagiwara, M.3    Sano, M.4    Hayashi, K.5    Inoue, T.6    Naito, K.7    Toshioka, T.8    Hidaka, H.9
  • 10
    • 0018111222 scopus 로고
    • The role of cyclic AMP-dependent protein kinase in the regulation of glycogen metabolism in mammalian skeletal muscle
    • COHEN, P. (1978). The role of cyclic AMP-dependent protein kinase in the regulation of glycogen metabolism in mammalian skeletal muscle. Curr. Top. Cell. Regul., 14, 118-196.
    • (1978) Curr. Top. Cell. Regul. , vol.14 , pp. 118-196
    • Cohen, P.1
  • 11
    • 0024263139 scopus 로고
    • A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system
    • DUMUIS, A., BOUHELAL, R., SEBBEN, M., CORY, R. & BOCKAERT, J. (1988). A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Mol. Pharmacol., 34, 880-887.
    • (1988) Mol. Pharmacol. , vol.34 , pp. 880-887
    • Dumuis, A.1    Bouhelal, R.2    Sebben, M.3    Cory, R.4    Bockaert, J.5
  • 13
    • 0026611585 scopus 로고
    • + current in colliculi neurones via activation of a cyclic AMP-dependent protein kinase
    • + current in colliculi neurones via activation of a cyclic AMP-dependent protein kinase. Br. J. Pharmacol., 105, 973-979.
    • (1992) Br. J. Pharmacol. , vol.105 , pp. 973-979
    • Fagni, L.1    Dumuis, A.2    Sebben, M.3    Bockaert, J.4
  • 15
    • 0023803473 scopus 로고
    • Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase
    • FRANCIS, S.H., NOBLETT, B.D., TODD, B.W., WELLS, J.N, & CORBIN, J.D. (1988). Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. Mol. Pharmacol., 34, 506-517.
    • (1988) Mol. Pharmacol. , vol.34 , pp. 506-517
    • Francis, S.H.1    Noblett, B.D.2    Todd, B.W.3    Wells, J.N.4    Corbin, J.D.5
  • 16
    • 0000328674 scopus 로고
    • The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory
    • ed. Blaschko, H.R. & Muscholl, E. Berlin, Heidelberg, New York: Springer-Verlag
    • FURCHGOTT, R.F. (1972). The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory. In Catecholamines, Hand. Exp. Pharmacol., vol. 33, ed. Blaschko, H.R. & Muscholl, E. pp. 283-335. Berlin, Heidelberg, New York: Springer-Verlag.
    • (1972) Catecholamines, Hand. Exp. Pharmacol. , vol.33 , pp. 283-335
    • Furchgott, R.F.1
  • 19
    • 0018166505 scopus 로고
    • Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets
    • HASLAM, R.J., DAVIDSON, M.M.L. & DESJARDINS, J.V. (1978). Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Biochem. J., 176, 83-95.
    • (1978) Biochem. J. , vol.176 , pp. 83-95
    • Haslam, R.J.1    Davidson, M.M.L.2    Desjardins, J.V.3
  • 20
    • 0025967721 scopus 로고
    • Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of vas deferens by cyclic AMP analogs
    • HEI, Y.-J., MACDONELL, K.L., MCNEILL, J.H. & DIAMOND, J. (1991). Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of vas deferens by cyclic AMP analogs. Mol. Pharmacol., 39, 233-238.
    • (1991) Mol. Pharmacol. , vol.39 , pp. 233-238
    • Hei, Y.-J.1    Macdonell, K.L.2    Mcneill, J.H.3    Diamond, J.4
  • 22
    • 0027144035 scopus 로고
    • 4 receptors by GR 113808
    • 4 receptors by GR 113808. Br. J. Pharmacol., 110, 1172-1174.
    • (1993) Br. J. Pharmacol. , vol.110 , pp. 1172-1174
    • Kaumann, A.J.1
  • 26
    • 0018337894 scopus 로고
    • Phosphorylation-dephosphorylation of enzymes
    • KREBS, E.G. & BEAVO, J.A. (1979). Phosphorylation-dephosphorylation of enzymes. Annu. Rev. Biochem., 48, 923-959.
    • (1979) Annu. Rev. Biochem. , vol.48 , pp. 923-959
    • Krebs, E.G.1    Beavo, J.A.2
  • 28
    • 0027522536 scopus 로고
    • Further concerns over Cheng-Prusoff analysis
    • LEFF, P. & DOUGALL, I.G. (1993). Further concerns over Cheng-Prusoff analysis. Trends Pharmacol. Sci., 14, 110-112.
    • (1993) Trends Pharmacol. Sci. , vol.14 , pp. 110-112
    • Leff, P.1    Dougall, I.G.2
  • 29
    • 0029041364 scopus 로고
    • Investigation of the 5-hydroxytryptamine receptor mediating the transient short-circuit current response in guinea-pig ileal mucosa
    • LEUNG, E., BLISSARD, D., JETT, M.F. & EGLEN, R.M. (1995). Investigation of the 5-hydroxytryptamine receptor mediating the transient short-circuit current response in guinea-pig ileal mucosa. Naunvn-Schmiedeberg's Arch. Pharmacol., 351, 596-602.
    • (1995) Naunvn-Schmiedeberg's Arch. Pharmacol. , vol.351 , pp. 596-602
    • Leung, E.1    Blissard, D.2    Jett, M.F.3    Eglen, R.M.4
  • 30
    • 0029025454 scopus 로고
    • Extended concentration-response curves used to reflect full agonist efficacies and receptor occupancy-response coupling ranges
    • LEW, M.J. (1995). Extended concentration-response curves used to reflect full agonist efficacies and receptor occupancy-response coupling ranges. Br. J. Pharmacol., 115, 745-752.
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 745-752
    • Lew, M.J.1
  • 32
    • 0026026348 scopus 로고
    • Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenylyl cyclase inhibitors MDL 12330A and SQ 22536
    • LIPPE, C. & ARDIZZONE, C. (1991). Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenylyl cyclase inhibitors MDL 12330A and SQ 22536. Comp. Biochem. Physiol., 99c, 209-211.
    • (1991) Comp. Biochem. Physiol. , vol.99 C , pp. 209-211
    • Lippe, C.1    Ardizzone, C.2
  • 33
    • 0026479969 scopus 로고
    • The PDE IV family of calcium-independent phosphodiesterase enzymes
    • LOWE III, J.A. & CHENG, J.B. (1992). The PDE IV family of calcium-independent phosphodiesterase enzymes. Drugs Future, 17, 799.
    • (1992) Drugs Future , vol.17 , pp. 799
    • Lowe III, J.A.1    Cheng, J.B.2
  • 34
    • 0025719927 scopus 로고
    • Histamine-induced increases in cyclic AMP levels in bovine adrenal medullary cells
    • MARLEY, P.D., THOMSON, K.A., JACHNO, K. & JOHNSTON, M.J. (1991). Histamine-induced increases in cyclic AMP levels in bovine adrenal medullary cells. Br. J. Pharmacol., 104, 839-846.
    • (1991) Br. J. Pharmacol. , vol.104 , pp. 839-846
    • Marley, P.D.1    Thomson, K.A.2    Jachno, K.3    Johnston, M.J.4
  • 35
    • 0028982771 scopus 로고
    • 4 receptor antagonist affinities of SB207710, SB205008, and SB203186 in the human colon, rat oesophagus, and guinea-pig ileum peristaltic reflex
    • 4 receptor antagonist affinities of SB207710, SB205008, and SB203186 in the human colon, rat oesophagus, and guinea-pig ileum peristaltic reflex. Naunyn-Schmiedeberg's Arch. Pharmacol., 352, 132-140.
    • (1995) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.352 , pp. 132-140
    • Mclean, P.G.1    Coupar, I.M.2
  • 36
    • 85035170559 scopus 로고
    • 3 receptor mediating contraction of rat isolated jejunum
    • Dec, 1995, Adelaide, Australia, Ed. Ching, M.S. & Widdop, R.E.
    • 3 receptor mediating contraction of rat isolated jejunum. Proc. 29th ASCEPT meeting, Dec, 1995, Adelaide, Australia, Ed. Ching, M.S. & Widdop, R.E., p. 139.
    • (1995) Proc. 29th ASCEPT Meeting , pp. 139
    • Mclean, P.G.1    Coupar, I.M.2
  • 37
    • 85035169241 scopus 로고
    • 4-like receptors in the circular smooth muscle of human colon stimulates cyclic AMP formation
    • Dec, 1995, Adelaide, Australia, ed. Ching, M.S. & Widdop, R.E.
    • 4-like receptors in the circular smooth muscle of human colon stimulates cyclic AMP formation. Proc. 29th ASCEPT meeting, Dec, 1995, Adelaide, Australia, ed. Ching, M.S. & Widdop, R.E., p. 67.
    • (1995) Proc. 29th ASCEPT Meeting , pp. 67
    • Mclean, P.G.1    Coupar, I.M.2
  • 38
    • 0030034178 scopus 로고    scopus 로고
    • 4-like receptor in the circular smooth muscle of human colon stimulates cyclic AMP formation
    • 4-like receptor in the circular smooth muscle of human colon stimulates cyclic AMP formation. Br. J. Pharmacol., 117, 238-239.
    • (1996) Br. J. Pharmacol. , vol.117 , pp. 238-239
    • Mclean, P.G.1    Coupar, I.M.2
  • 40
    • 0027164208 scopus 로고
    • Isolation and characterization of a previously undetected human cAMPphosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae
    • MICHAELI, T., BLOOM, T.J., MARTINS, T., LOUGHNEY, K., FERGUSON, K., RIGGS, M., RODGERS, L., BEAVO, J.A. & WIGLER, M. (1993). Isolation and characterization of a previously undetected human cAMPphosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. J. Biol. Chem., 268, 12925-12932.
    • (1993) J. Biol. Chem. , vol.268 , pp. 12925-12932
    • Michaeli, T.1    Bloom, T.J.2    Martins, T.3    Loughney, K.4    Ferguson, K.5    Riggs, M.6    Rodgers, L.7    Beavo, J.A.8    Wigler, M.9
  • 41
    • 0027477974 scopus 로고
    • Pharmacological characterization of the 5-hydroxytryptamine receptor coupled to adenylyl cyclase stimulation in human brain
    • MONFERINI, E., GAETANI, P., RODRIGEZ, Y., BAENA, R., PARENTI, M., ZOCCHETTI, A. & RIZZI, C.A. (1993). Pharmacological characterization of the 5-hydroxytryptamine receptor coupled to adenylyl cyclase stimulation in human brain. Life Sci., 52, PL61-65.
    • (1993) Life Sci. , vol.52
    • Monferini, E.1    Gaetani, P.2    Rodrigez, Y.3    Baena, R.4    Parenti, M.5    Zocchetti, A.6    Rizzi, C.A.7
  • 42
    • 0026008409 scopus 로고
    • Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes
    • NICHOLSON, C.D., CHALLISS, R.A. & SHAHID, M (1991). Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol. Sci., 12, 19-27.
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 19-27
    • Nicholson, C.D.1    Challiss, R.A.2    Shahid, M.3
  • 44
    • 0022459284 scopus 로고
    • Stereospecific binding of the antidepressant rolipram to brain protein structures
    • SCHNEIDER, H.H., SCHMIECHEN, R., BREZINSKI, M & SEIDLER, J. (1986). Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur. J. Pharmacol., 127, 105-115.
    • (1986) Eur. J. Pharmacol. , vol.127 , pp. 105-115
    • Schneider, H.H.1    Schmiechen, R.2    Brezinski, M.3    Seidler, J.4
  • 45
    • 0015493877 scopus 로고
    • Studies on the mechanism of hormone action
    • SUTHERLAND, E.W. (1972). Studies on the mechanism of hormone action. Science, 177, 401-408.
    • (1972) Science , vol.177 , pp. 401-408
    • Sutherland, E.W.1
  • 46
    • 0027991689 scopus 로고
    • Characterisation of the 5-Hydroxytryptamine receptor type involved in inhibition of spontaneous activity of human isolated colonic circular muscle
    • TAM, F.S.-F., HILLIER, K., BUNCE, K.T. (1994). Characterisation of the 5-Hydroxytryptamine receptor type involved in inhibition of spontaneous activity of human isolated colonic circular muscle. Br. J. Pharmacol., 113, 143-150.
    • (1994) Br. J. Pharmacol. , vol.113 , pp. 143-150
    • Tam, F.S.-F.1    Hillier, K.2    Bunce, K.T.3
  • 48
    • 0027953891 scopus 로고
    • Characterization of the 5-HT receptor potentiating neuromuscular cholinergic transmission in strips of human isolated detrussor muscle
    • TONINI, M., MESSORI, E., FRANCESCHETTI, G.P., RIZZI, C.A., CASTOLDI, A.F., COCCINI, T. & CANDURA, S.M. (1994). Characterization of the 5-HT receptor potentiating neuromuscular cholinergic transmission in strips of human isolated detrussor muscle. Br. J. Pharmacol., 113, 1-2.
    • (1994) Br. J. Pharmacol. , vol.113 , pp. 1-2
    • Tonini, M.1    Messori, E.2    Franceschetti, G.P.3    Rizzi, C.A.4    Castoldi, A.F.5    Coccini, T.6    Candura, S.M.7
  • 50
    • 0019444366 scopus 로고
    • Phosphodiesterase inhibitors as tools in cyclic nucleotide research: A precautionary comment
    • WELLS, J.N. & KRAMER, G.L. (1981). Phosphodiesterase inhibitors as tools in cyclic nucleotide research: a precautionary comment. Mol. Cell. Endocrinol., 23, 1-9.
    • (1981) Mol. Cell. Endocrinol. , vol.23 , pp. 1-9
    • Wells, J.N.1    Kramer, G.L.2


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