Folic acid fortified milk increases blood folate and lowers homocysteine concentration in women of childbearing age

Asia Pacific Journal of Clinical Nutrition

Volumn 14, Issue 2, 2005, Pages 173-178

  Green, Timothy J ^a   Skeaff, C Murray ^a   Rockell, Jennifer E P ^a   Venn, Bernard J ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Folic acid; Fortification; Homocysteine; Milk; NTD; Plasma folate; Red blood cell folate; Women

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

ADULT; AGE; ARTICLE; CONCENTRATION (PARAMETERS); CONFIDENCE INTERVAL; CONTROLLED STUDY; DRINKING; ERYTHROCYTE; FEMALE; FOLIC ACID BLOOD LEVEL; FOOD INTAKE; HEMOCONCENTRATION; HUMAN; HUMAN EXPERIMENT; MILK; NORMAL HUMAN; POWDER; RANDOMIZATION;

ADOLESCENT; ADULT; ANIMALS; BIOLOGICAL AVAILABILITY; DOUBLE-BLIND METHOD; ERYTHROCYTES; FEMALE; FOLIC ACID; FOOD, FORTIFIED; HOMOCYSTEINE; HUMANS; MIDDLE AGED; MILK; NEURAL TUBE DEFECTS; NUTRITIONAL STATUS;

EID: 20044388952     PISSN: 09647058     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991; 338: 131-7.
2. Czeizel AE, Dudas I. Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation. N Engl J Med 1992; 327: 1832-5.
3. Berry RJ, Li Z, Erickson JD, Li S, Moore CA, Wang H, Mulinare J, Zhao P, Wong LC, Gindler J, Hong S, Correa A. Prevention of neural-tube defects with folic acid in China. N Engl J Med 1999; 341: 1485-90.
4. Centres for Disease Control Control. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. Morb Mortal Wkly Rep 1992; 41: 1-7.
5. Department of Health. Report from an Expert Advisory group. Folic acid and the prevention of neural tube defects. London: Department of Health, 1992.
6. Fox AM. Primary prevention of neural tube defects: notice from the HPB. CMAJ 1993; 149: 1231-2.
7. De Wals P, Rusen ID, Lee NS, Morin P, Niyonsenga T. Trend in prevalence of neural tube defects in Quebec. Birth Defects Res Part A Clin Mol Teratol 2003; 67: 919-23.
8. Anonymous. Spina bifida and anencephaly before and after folic acid mandate - United States, 1995-1996 and 1999-2000. Morb Mortal Wkly Rep 2004; 53: 362-5.
9. Castilla EE, Orioli IM, Lopez-Camelo JS, Dutra Mda G, Nazer-Herrera J. Preliminary data on changes in neural tube defect prevalence rates after folic acid fortification in South America. Am J Med Genet 2003; 123A: 123-8.
10. Daly LE, Kirke PN, Molloy A, Weir DG, Scott JM. Folate levels and neural tube defects. Implications for prevention. JAMA 1995; 274: 1698-702.
11. Mills JL, McPartlin JM, Kirke PN, Lee YJ, Conley MR, Weir DG, Scott JM. Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 1995; 345: 149-51.
12. Ray JG, Laskin CA. Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, preeclampsia and spontaneous pregnancy loss: A systematic review. Placenta 1999; 20: 519-29.
13. Homocysteine Lowering Trialist's Collaboration. Lowering blood homocysteine with folic acid-based supplements: meta-analysis of randomised trials. BMJ 1998;316: 894-98.
14. Riddell LJ, Chisholm A, Williams S, Mann JI. Dietary strategies for lowering homocysteine concentrations. Am.-J.- Clin.- Nutr.- 2000; 71: 1448-54.
15. New Zealand Institute of Crop and Food Research. Food Files. The New Zealand Food Composition Database. Palmerston North: New Zealand Institute of Crop and Food Research; 1993.
16. O'Broin S, Kelleher B. Microbiological assay on microtitre plates of folate in serum and red cells. J Clin Pathol 1992; 45: 344-7.
17. Norsworthy B, Skeaff CM, Adank C, Green TJ. Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women. Eur J Clin Nutr 2004; 58: 548-54.
18. Adank C, Green TJ, Skeaff CM, BK B. Folic acid supplementation in women - monitoring changes in red cell folate. Ann Nutr Metabol 2001; 45 (S1): 56.
19. Cuskelly GJ, McNulty H, Scott JM. Effect of increasing dietary folate on red-cell folate: implications for prevention of neural tube defects. Lancet 1996; 347: 657-9.
20. Green T, Newton R, Bourn D. Estimated folic acid intakes from simulated fortification of the New Zealand food supply. NZ Med J 2003; 116: U294.
21. Adank C, Green TJ, Skeaff CM, Briars B. Weekly high-dose folic acid supplementation is effective in lowering serum homocysteine concentrations in women. Ann Nutr Metab 2003; 47: 55-9.
22. Lamers Y, Prinz-Langenohl R, Moser R, Pietrzik K. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women. Am J Clin Nutr 2004; 79: 473-8.
23. Ray JG, Vermeulen MJ, Boss SC, Cole DE. Increased red cell folate concentrations in women of reproductive age after Canadian folic acid food fortification. Epidemiology 2002; 13: 238-40.
24. Anonymous. Folate status in women of childbearing age - United States, 1999. Morb Mortal Wkly Rep 2000; 49: 962-5.