Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 6, 2005, Pages 1697-1700

  Clark, Robin D ^a   Jahangir, Alam ^a   Alam, Muzaffar ^a   Rocha, Cynthia ^a,b   Lin, Lin ^a   Bjorner, Bodil ^a   Nguyen, Khanh ^a   Grady, Carole ^a   Williams, Timothy J ^a   Stepan, George ^a   Tang, Hai Ming ^a   Ford, Anthony P D W ^a  

^a ROCHE BIOSCIENCE   (United States)

^b Inst Ric Biomediche Antoine M   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; BENZODIOXANE CARBOXAMIDE; SEROTONIN 4 ANTAGONIST; SEROTONIN 4 RECEPTOR; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOG; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG METABOLISM; DRUG PENETRATION; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER MICROSOME; NONHUMAN; URINE INCONTINENCE; ANIMAL; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; MINIPIG; MOUSE; RAT; STRUCTURE ACTIVITY RELATION; SWINE;

ANIMALS; DOGS; HETEROCYCLIC COMPOUNDS, 2-RING; MICE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; RATS; RECEPTORS, SEROTONIN, 5-HT4; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; SWINE, MINIATURE;

EID: 20044386650     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.01.039     Document Type: Article

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