Double-blind study of the effect of cisapride on constipation and abdominal discomfort as components of the irritable bowel syndrome

Alimentary Pharmacology and Therapeutics

Volumn 11, Issue 2, 1997, Pages 387-394

  Schutze K ^a   Brandstatter G ^b   Dragosics, B ^c   Judmaier, G ^d   Hentschel, E ^a  

^a HANUSCH HOSPITAL   (Austria)

^b General Hospital Southwest   (Austria)

^c Out patient Department South   (Austria)

^d UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CISAPRIDE; PLACEBO;

ABDOMINAL DISCOMFORT; ABDOMINAL PAIN; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0030967149     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1997.133311000.x     Document Type: Article

References (17)

1. Klein KB. Controlled treatment trials in the irritable bowel syndrome: A critique. Gastroenterology 1988; 95: 232-41.
2. Thompson WG. Irritable bowel syndrome: pathogenesis and management. Lancet 1993; 341: 1569-72.
3. Mc Callum RW, Prakash C, Campoli-Richards DH, Goa KL. Cisapride: a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders. Drugs 1988; 36: 652-81.
4. Nakayama S, Neya T, Yamesato T, Tokaki M, Itano N. Effects on cisapride on the motility of digestive tract in dogs and guinea pigs. Jpn J Smooth Muscle Res 1985; 21: 1-9.
5. Hernandez R, Troncoso G, Palencia C, Maldonado S. Double blind dose-response study of cisapride in the treatment of chronic functional constipation. Adv Ther 1988; 5: 121-7.
6. Vervaeke M, Verheyen K, Verlinden M, Reyntjens A. Effect on cisapride on bowel habit. Progr Med 1987; 43(Suppl. 1): 145-54.
7. Müllner-Lissner SA, Boehm G, Bouzo MH, et al Treatment of chronic constipation with cisapride and placebo. Gut 1987; 28: 1033-8.
8. Verheyen K, Vervaeke M, Dermythenaere P, Van Mierlo FJ. Double-blind comparison of two cisapride dosage regimens with placebo in the treatment of functional constipation. A general-practice multicenter study. Curr Ther Res 1987; 41: 978-85.
9. Thompson WG, Dotevall G, Drossman DA, Heaton KW, Kruis W. Irritable bowel syndrome: guidelines for the diagnosis. Gastroenterol Int 1989; 2: 92-5.
10. Kruis W, Thieme CH, Weinzierl M, Schüssler P, Holl J, Paulus W. A diagnostic score for the irritable bowel syndrome. Gastroenterology 1984; 87: 1-7.
11. Passaretti S, Tittobello A, Capozzi C, Verlinden M. Cisapride accelerates total intestinal transit in patients with irritable bowel syndrome associated constipation. Progr med 1987; 43(Suppl. 1): 121-9.
12. Van Outryve M, Milo R, Toussaint J, Van Eeghem P. 'Prokinetic' treatment of constipation-predominant irritable bowel syndrome: A placebo-controlled study of cisapride. J Clin Gastroenterol 1991; 13(1): 49-57.
13. Whitehead WE, Holtkotter B, Enck P, et al. Tolerance for rectosigmoid distension in irritable bowel syndrome. Gastroenterology 1990; 98: 1187-92.
14. Talley NJ, Zinsmeister AR, Van Dyke C, Melton LJ. Epidemiology of colonic symptoms and the irritable bowel syndrome. Gastroenterology 1991; 101: 927-34.
15. Drossmann DA, McKee D, Sandler RS, et al. Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome. Gastroenterology 1988; 95: 701-8.
16. Whitehead WE, Bosmajion L, Zonderman AD, Costa PT, Schuster MN. Symptoms of psychologic distress associated with irritable bowel syndrome. Comparison of community and medical clinical samples. Gastroenterology 1988; 95: 709-14.
17. Agreus L, Svärdsudd K, Nyren O, Tibblin G. Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology 1995; 109: 671-80.