Synthesis and characterization of copper(II) complexes of 4-alkyl/aryl-1,2-naphthoquinones thiosemicarbazones derivatives as potent DNA cleaving agents

Inorganica Chimica Acta

Volumn 358, Issue 6, 2005, Pages 2023-2030

  Afrasiabi, Zahra ^a   Sinn, Ekk ^a   Kulkarni, Prasad P ^b,e   Ambike, Vinita ^b   Padhye, Subhash ^b   Deobagakar, Deepti ^b   Heron, Mark ^c   Gabbutt, Chris ^c   Anson, Christopher E ^d   Powell, Annie K ^d  

^a MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

^b UNIVERSITY OF PUNE   (India)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d UNIVERSITY OF KARLSRUHE   (Germany)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

1,2 naphthoquinones; Copper; Nuclease activity; Thiosemicarbazone

Indexed keywords

AMINES; COPPER; CRYSTAL STRUCTURE; DNA; KETONES; LIGANDS; LINEARIZATION; OXIDANTS; PHENOLS; SYNTHESIS (CHEMICAL);

AEROBIC CONDITION; DNA CLEAVING ACTIVITY; DOUBLE-STRANDED PLASMID; INTERACTION WITH DNAS; NAPHTHOQUINONES; NUCLEASE ACTIVITY; SYNTHESIS AND CHARACTERIZATIONS; THIOSEMICARBAZONES;

COPPER COMPOUNDS;

1,2 NAPHTHOQUINONE DERIVATIVE; 4 (2,3 DIHYDROINDOL 1 YL)[1,2]NAPHTHOQUINONE 1 THIOSEMICARBAZONE; 4 MORPHOLIN 4 YL[1,2]NAPHTHOQUINONE 1 THIOSEMICARBAZONE; 4 PIPERIDIN 1 YLDIBENZOFURAN 1,2 DIONE 1 THIOSEMICARBAZONE; 4 PYRROLIDIN 1 YL[1,2]NAPHTHOQUINONE 1 THIOSEMICARBAZONE; COPPER COMPLEX; DOUBLE STRANDED DNA; HYDROGEN PEROXIDE; PLASMID DNA; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DNA CLEAVAGE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE;

EID: 20044372883     PISSN: 00201693     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ica.2004.12.042     Document Type: Article

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