A practical entry to C18-constrained-E-ring analogues of methyllycaconitine (MLA): A concise new stereoselective approach to 8-oxa-decahydroisoquinolines accompanied by a simple microwaves-assisted synthesis of the succinimidobenzoate appendage of MLA

Tetrahedron Letters

Volumn 46, Issue 5, 2005, Pages 759-762

  Simoni, Daniele ^a   Rossi, Marcello ^a   Rondanin, Riccardo ^a   Baruchello, Riccardo ^a   Grisolia, Giuseppina ^a   Eleopra, Marco ^a   Giovannini, Riccardo ^b   Bozzoli, Andrea ^b   Davalli, Silvia ^b   Di Fabio, Romano ^b   Donati, Daniele ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b GSK   (Italy)

Author keywords

Decahydroisoquinoline synthesis; Methyllycaconitine; Microwave assisted chemistry; Nicotinic acetylcholine receptor antagonists

Indexed keywords

8 OXADECAHYDROISOQUINOLINE; ALKALOID DERIVATIVE; HETEROCYCLIC COMPOUND; ISOQUINOLINE DERIVATIVE; METHYLLYCACONITINE; SUCCINIMIDE DERIVATIVE; SUCCINIMIDOBENZOATE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CYCLIZATION; DRUG SYNTHESIS; MANNICH REACTION; MICROWAVE RADIATION; MOLECULAR INTERACTION; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 19944428573     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.12.029     Document Type: Article

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