Experimental transmission of chronic wasting disease agent from mule deer to cattle by the intracerebral route

Journal of Veterinary Diagnostic Investigation

Volumn 17, Issue 3, 2005, Pages 276-281

  Hamir, Amir N ^a   Kunkle, Robert A ^a   Cutlip, Randall C ^a   Miller, Janice M ^a   O'Rourke, Katherine I ^b   Williams, Elizabeth S ^c   Miller, Michael W ^d   Stack, Mick J ^e   Chaplin, Melanie J ^e   Richt, Jürgen A ^a  

^a NATIONAL ANIMAL DISEASE CENTER   (United States)

^b USDA ARS Pullman   (United States)

^c UNIVERSITY OF WYOMING   (United States)

^d NATIONAL WILDLIFE RESEARCH CENTER   (United States)

^e Veterinary Services Agency   (United Kingdom)

Author keywords

Cattle; Chronic wasting disease (CWD) of mule deer; Prion disease

Indexed keywords

ANIMALIA; BOS TAURUS; BOVINAE; CERVIDAE; ODOCOILEUS HEMIONUS;

EID: 19944412183     PISSN: 10406387     EISSN: None     Source Type: Journal    
DOI: 10.1177/104063870501700313     Document Type: Article

References (20)

1. Cutlip RC, Miller JM, Hamir AN, et al.: 2001, Resistance of cattle to scrapie by the oral route. Can J Vet Res 65:133-132.
2. Cutlip RC, Miller JM, Lehmkuhl HD: 1997, Second passage of a US scrapie agent in cattle. J Comp Pathol 117:271-275.
3. Cutlip RC, Miller JM, Race RE, et al.: 1994, Intracerebral transmission of scrapie to cattle. J Infect Dis 169:814-820.
4. Diedrich JF, Bendheim PE, Kim YS, et al.: 1991, Scrapie-associated prion protein accumulates in astrocytes during scrapie infection. Proc Natl Acad Sci USA 88:375-379.
5. Gavier-Widen D, Wells GAH, Simmons MM, et al.: 2001, Histological observations on the brains of symptomless 7-year-old cattle. J Comp Pathol 124:52-59.
6. Guiroy DC, Williams ES, Yanagihara R, et al.: 1991, Immunolocalization of scrapie amyloid (PrP 27-30) in chronic wasting disease of Rocky Mountain elk and hybrids of captive mule deer and white-tailed deer. Neurosci Lett 126:195-198.
7. Hamir AN, Cutlip RC, Miller JM, et al.: 2001, Preliminary findings on the experimental transmission of chronic wasting disease agent of mule deer to cattle. J Vet Diagn Invest 13:91-96.
8. Hamir AN, Miller JM, Cutlip RC, et al.: 2004, Transmission of sheep scrapie to elk (Cervus elaphus nelsoni) by intracerebral inoculation: final outcome of the experiment. J Vet Diagn Invest 16:316-321.
9. Hamir AN, Miller JM, Stack MJ, et al.: 2002, Intracerebral inoculation of genetically susceptible sheep with scrapie agent: failure to detect abnormal prion protein and scrapie associated fibrils six weeks post inoculation. Can J Vet Res 66:289-294.
10. Hamir AN, Miller JM, Stack MJ, et al.: 2002, Neuroaxonal Dystrophy in Raccoons (Procyon lotor) from Iowa. J Vet Diagn Invest 14:175-178.
11. Harper PAW, Morton AG: 1991, Neuroaxonal dystrophy in Merino sheep. Aust Vet J 68:113-114.
12. Heaton MP, Leymaster KA, Freking BA, et al.: 2003, Prion gene sequence variation within diverse groups of US sheep, beef cattle, and deer. Mamm Genome 14:765-777.
13. Miller JM, Jenny AL, Taylor WD, et al.: 1994, Detection of prion protein in formalin-fixed brain by hydrated autoclaving immunohistochemistry for diagnosis of scrapie in sheep. J Vet Diagn Invest 6:366-368.
14. Miller MW, Williams ES, McCarty CW, et al.: 2000, Epizootiology of chronic wasting disease in free-ranging cervids in Colorado and Wyoming. J Wildl Dis. 36:676-690.
15. O'Rourke KI, Baszler TV, Besser TE, et al.: 2000, Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissue. J Clin Microbiol 38:3254-3259.
16. O'Rourke KI, Baszler TV, Miller JM, et al.: 1998, Monoclonal antibody F89/160.1.5 defines a conserved epitope on the ruminant prion protein. J Clin Microbiol 36:1750-1755.
17. Raymond GJ, Bossers A, Raymond LD, et al.: 2000, Evidence of a molecular barrier limiting susceptibility of humans, cattle, and sheep to chronic wasting disease. EMBO J. 19:4423-4430.
18. Sc detection and its use as a rapid surveillance method for the diagnosis of bovine spongiform encephalopathy (BSE). Acta Neuropathol 98:437-443.
19. Stack MJ, Keyes P, Scott AC: 1996, The diagnosis of bovine spongiform encephalopathy and scrapie by the detection of fibrils and the abnormal protein isoform. In: Methods in molecular medicine - prion diseases, ed. Baker HF, Ridley RM, pp. 85-104. Humana Press, Totowa, NJ.
20. Williams ES, Young S: 1992, Spongiform encephalopathies in cervidae. Rev Sci Tech Off Int Epiz 11:551-567.