Affinity selection to papain yields potent peptide inhibitors of cathepsins L, B, H, and K

Biochemical and Biophysical Research Communications

Volumn 332, Issue 3, 2005, Pages 897-903

  Bratkovič, Tomaž ^a,b   Lunder, Mojca ^a   Popovič, Tatjana ^c   Kreft, Samo ^a   Turk, Boris ^c   Štrukelj, Borut ^a,c   Urleb, Uroš ^a,b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b Lek Pharmaceuticals   (Slovenia)

^c JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

Affinity selection; Cathepsins; Inhibitor; Papain; Peptide; Phage display; Selective elution

Indexed keywords

CATHEPSIN B; CATHEPSIN H; CATHEPSIN K; CATHEPSIN L; CYSTEINE PROTEINASE INHIBITOR; CYSTEINYLASPARAGINYLALANYLALANYLGLYCYLTYROSYLASPARAGINYLCYSTEINYLGLYCYL GLYCYLGLYCYLSERINAMIDE; CYSTEINYLASPARAGINYLTRYPTOPHYLTHREONYLLEUCYLGLYCYLGLYCYLTYROSYLLYSYL CYSTEINYLGLYCYLGLYCYLGLYCYLSERINAMIDE; CYSTEINYLTRYPTOPHYLGLUTAMYLTRYPTOPHYLGLYCYLGLYCYLTRYPTOPHYLHISTIDYL CYSTEINYLGLYCYLGLYCYLSERYLSERINE; CYSTEINYLTRYPTOPHYLSERYLMETHIONYLMETHIONYLGLYCYLPHENYLALANYLGLUTAMINYL CYSTEINYLGLYCYLGLYCYLSERINAMIDE; GLYCYLASPARAGINYLTRYPTOPHYLTHREONYLLEUCYLGLYCYLGLYCYLTYROSYLLYSYLGLYCYL GLYCINE; PAPAIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; INHIBITION KINETICS; PRIORITY JOURNAL;

EID: 19744374543     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.05.028     Document Type: Article

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