The effect of mianserin add-on, on the intensity of opioid withdrawal symptoms during detoxification program - A randomized, double blind, placebo controlled, prospective study

Addictive Behaviors

Volumn 30, Issue 6, 2005, Pages 1154-1167

  Herman, I ^a   Shamir, D ^a   Bar Hamburger, R ^b   Pick, C G ^a   Schreiber, S ^c  

^a TEL AVIV UNIVERSITY   (Israel)

^b Israel Anti Drug Authority   (Israel)

^c TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

Antidepressants; Mianserin; Opioid detoxification; Trazodone; Withdrawal

Indexed keywords

CHLORDIAZEPOXIDE; CLONIDINE; DIPYRONE; LEVOMEPROMAZINE; METOCLOPRAMIDE; MIANSERIN; ORPHENADRINE CITRATE; PAPAVERINE; PHENOBARBITAL; PLACEBO; TRAZODONE;

ANXIETY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DETOXIFICATION; DOUBLE BLIND PROCEDURE; HUMAN; MAJOR CLINICAL STUDY; MALE; METHODOLOGY; OPIATE ADDICTION; PROSPECTIVE STUDY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RELAPSE; SIDE EFFECT; WITHDRAWAL SYNDROME;

ANALYSIS OF VARIANCE; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANXIETY; DEPRESSIVE DISORDER; DOUBLE-BLIND METHOD; HUMANS; MALE; MIANSERIN; OPIOID-RELATED DISORDERS; PATIENT COMPLIANCE; PROSPECTIVE STUDIES; SUBSTANCE WITHDRAWAL SYNDROME; SURVIVAL ANALYSIS;

EID: 19744367349     PISSN: 03064603     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addbeh.2004.12.004     Document Type: Article

References (34)

1. H. Akil, F. Meng, D.P. Devine, and S.J. Watson Molecular and neuroanatomical properties of the endogenous opioid system: Implications for treatment of opiate addiction Seminars in the Neurosciences 9 1997 70
2. American Psychiatric Association Diagnostic and statistical manual of mental disorders 4th ed. 1994 Author Washington, DC
3. American Psychiatric Association Practice guideline for the treatment of patients with substance use disorders: Alcohol, cocaine, opioids American Journal of Psychiatry 152 1995 5 (Suppl.)
4. M. Backmund, K. Meyer, D. Eichenlaub, and C.G. Schutz Predictors for completing an inpatient detoxification program among intravenous heroin users, methadone substituted and codeine substituted patients Drug and Alcohol Dependence 64 2001 173 180
5. J. Bearn, M. Gossop, and J. Strang Randomized double-blind comparison of lofexidine and methadone in the inpatient treatment of opiate withdrawal Drug and Alcohol Dependence 43 1996 87 91
6. B. Broers, F. Giner, P. Dumont, and A. Mino Inpatient opiate detoxification in Geneva: Follow-up at 1 and 6 months Drug and Alcohol Dependence 58 2000 85 92
7. R.K. Brooner, V.L. King, M. Kidorf, C.W. Schmidt, and G.E. Bigelow Psychiatric and substance use comorbidity among treatment seeking opioid abusers Archives of General Psychiatry 54 1997 71
8. S. Darke, and J. Ross Polydrug dependence and psychiatric comorbidity among heroin injectors Drug and Alcohol Dependence 48 1997 135
9. M. Gossop, L. Green, G. Phillips, and B. Bradlley Lapse, relapse and survival among opiate addicts after treatment. A prospective follow-up study British Journal of Psychiatry 154 1989 348 353
10. L.R. Gowing, R.L. Ali, and J.K. White Opioid antagonists and adrenergic agonists for the management of opioid withdrawal Cochrane Library, Issue 2 2002 Update Software Oxford
11. L.R. Gowing, M. Farrwl, R.L. Ali, and J.K. White α2-Adrenergic agonists in opioid withdrawal Addiction 97 2002 49 58
12. L.A. Green, B.P. Yaun, D. Lanier, and S.M. Dovey The ecology of medical care revisited NEJM 344 2001 2021 2025
13. M. Hamilton A rating scale for anxiety British Journal of Medical Psychology 23 1959 50 55
14. M. Hamilton A rating scale for depression Journal of Neurology, Neurosurgery and Psychiatry 23 1960 56 61
15. J.H. Jaffe, and A.B. Jaffe Opioid-related disorders Harold I. Kaplan Benjamin J. Sadock Virginia A. Sadock Kaplan and Sadock's comprehensive textbook of psychiatry 2000 Lippincott Williams & Wilkins New York
16. J.H. Jaffe, C.M. Knapp, and D.A. Ciraulo Opiates: Clinical aspects J.H. Lowinson P. Ruiz R.B. Millman J.G. Langrod Substance abuse: A comprehensive textbook 3rd ed. 1997 Williams & Wilkins Baltimore
17. S.M. Johnson, and W.W. Fleming Mechanisms of cellular adaptive sensitivity changes: Applications to opioid tolerance and dependence Pharmacological Reviews 41 1989 435 488
18. H.D. Kleber, and C.E. Riordan The treatment of narcotic withdrawal: A historical review Journal of Clinical Psychiatry 43 1982 30 34
19. H.D. Kleber, C.E. Riordan, B. Rounsaville, T. Koston, D. Charney, and J. Gaspari Clonidine in outpatient detoxification from methadone maintenance Archives of General Psychiatry 42 1985 391 394
20. G.F. Koob, and M. Le Moal Drug abuse: Hedonic homeostatic dysregulation Science 278 1997 52 58
21. W. Ling, and D.R. Wesson Clinical efficacy of buprenorphine: Comparisons to methadone and placebo Drug and Alcohol Dependence 70 2003 S49 S57
22. R.P. Mattick, and W. Hall Are detoxification programmes effective? Lancet 347 1996 97 100
23. A.T. McLellan, I.O. Arndt, D.S. Metzger, G.E. Woody, and C.P. O'Brien The effects of psychological services in substance abuse treatment JAMA 269 1993 1953
24. E.J. Nestler, and G.K. Aghajanian Molecular and cellular basis of addiction Science 278 1997 58
25. E.V. Nunes, F.C. Quitkin, S.J. Donovan, D. Deliyannides, K. Ocepek-Welikson, and T. Koenig Imipramine treatment of opiate-dependent patients with depressive disorders Archives of General Psychiatry 55 1998 153
26. P.G. O'Connor, and T.R. Kosten Management of opioid intoxication and withdrawal A.W. Graham T.K. Schultz Principles of addiction medicine 2nd ed. 1998 American Society of Addiction Medicine Maryland, USA 457 464
27. P. Sacerdote, A. Brini, P. Mantegazza, and E.A. Panerai A role for serotonin and β-endorphin in the analgesia induced by some tricyclic antidepressant drugs Pharmacology, Biochemistry and Behavior 26 1987 153 158
28. L. San, T. Fernandez, J. Cami, and M. Gossop Efficacy of methadone versus methadone and guanfacine in the detoxification of heroin-addicted patients Journal of Substance Abuse Treatment 11 1994 463 469
29. S. Schreiber, M.M. Backer, I. Herman, D. Shamir, R. Bar-Hamburger, and C.G. Pick Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice Addiction Biology 8 2003 107 114
30. S. Schreiber, M.M. Backer, J. Kaufman, T. Rigai, and C.G. Pick Interaction between the tetracyclic antidepressant mianserin HCl and opioid receptors European Neuropsychopharmacology 8 1998 297 302
31. S. Schreiber, M.M. Backer, and C.G. Pick The antinociceptive effect of trazodone in mice is mediated through both μ-opioid and serotonergic mechanisms Behavioural Brain Research 114 2000 51 56
32. S. Schreiber, A. Bleich, and C.G. Pick Venlafaxine and mirtazapine: Different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects-a possible opioid involvement in severe depression? Journal of Molecular Neuroscience 18 2002 143 149
33. G.E. Vaillant What can long-term follow-up teach us about relapse and prevention of relapse in addiction? British Journal of Addiction 83 1998 1147 1157
34. R.M. Wolfe Antidepressant withdrawal reactions American Family Physician 56 1997 455 462