Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors

European Journal of Medicinal Chemistry

Volumn 40, Issue 6, 2005, Pages 597-606

  Angibaud, Patrick ^a   Arts, Janine ^b   Van Emelen, Kristof ^c   Poncelet, Virginie ^a   Pilatte, Isabelle ^a   Roux, Bruno ^a   Van Brandt, Sven ^c   Verdonck, Marc ^c   De Winter, Hans ^d   Ten Holte, Peter ^c   Marien, Ann ^b   Floren, Wim ^b   Janssens, Boudewijn ^b   Van Dun, Jacky ^b   Aerts, An ^b   Van Gompel, Jacky ^e   Gaurrand, Sandrine ^a   Queguiner, Laurence ^a   Argoullon, Jean Michel ^a   Van Hijfte, Luc ^a   Freyne, Eddy ^c   Janicot, Michel ^b   more..

^a JOHNSON AND JOHNSON   (United States)

^b CNS Research   (Belgium)

^c Medicinal Chemistry Department   (Belgium)

^d Molecular Drug Design   (Belgium)

^e Preclinical Pharmacokinetics   (Belgium)

Author keywords

Anticancer agents; Histone deacetylase; Hydroxamic acid

Indexed keywords

2 [1 (NAPHTHALENE 2 SULFONYL)[(PIPERIDIN 4 YLMETHYL)AMINO]]PYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 [1 (NAPHTHALENE 2 SULFONYL)AZEPAN 4 YLAMINO]PYRIMIDINE 5 CARBOXYLIC ACID HYDROXAMIDE; 2 [1 (NAPHTHALENE 2 SULFONYL)PIPERIDIN 4 YLAMINO]PYRIMIDINE 5 CARBOXYLIC ACID HYDROXAMIDE; 2 [[1 (NAPHTHALENE 2 SULFONYL)PIPERIDIN 3 YLMETHYL]AMINO]PYRIMIDINE 5 CARBOXYLIC ACID HYDROXAMIDE; 2 [[4 (NAPHTHALENE 2 SULFONYL)MORPHOLIN 2 YLMETHYL]AMINO]PYRIMIDINE 5 CARBOXYLIC ACID HYDROXAMIDE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; N HYDROXY 6 [1 (NAPHTHALENE 2 SULFONYL)AZEPAN 4 YLAMINO]NICOTINAMIDE; N HYDROXY 6 [1 (NAPHTHALENE 2 SULFONYL)PIPERIDIN 4 YLAMINO]NICOTINAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

CELL PROLIFERATION; ENZYME INHIBITORS; FEMALE; HELA CELLS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PYRIMIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 19644387318     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.01.008     Document Type: Article

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