A randomized, double-blind, placebo-controlled study on the clinical efficacy of oral treatment with DermaVite™ on ageing symptoms of the skin

Journal of International Medical Research

Volumn 33, Issue 3, 2005, Pages 267-272

  Thom, Erling ^a,b  

^a ETC Research and Development   (Norway)

^b NONE   (Norway)

Author keywords

Ageing skin; Marine proteins; Placebo; Skin elasticity; Skin thickness; lipoic acid

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; COPPER; DERMATOLOGICAL AGENT; DERMAVITE; FISH PROTEIN; NATURAL PRODUCT; NICOTINAMIDE; PANTOTHENIC ACID; PINE EXTRACT; PLACEBO; PLANT EXTRACT; RED CLOVER EXTRACT; THIOCTIC ACID; TOMATO EXTRACT; UNCLASSIFIED DRUG; ZINC;

ADULT; AGING; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; ELASTICITY; FEMALE; HUMAN; MEDICAL ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SELF EVALUATION; SIDE EFFECT; SKIN MANIFESTATION; SKINFOLD THICKNESS; SOYBEAN; SYMPTOM; TELANGIECTASIA; TREATMENT OUTCOME; WRINKLE;

EID: 19644367140     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000503300301     Document Type: Article

References (9)

1. Kligman AM, Grove GL, Hirose R, Leyden JJ: Topical tretinoin for photoaged skin. J Am Acad Dermatol 1986; 15: 836-859.
2. Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, Voorhees JJ: Topical tretinoin improves photooged skin. A double-blind vehicle-controlled study. JAMA 1988; 259: 527-532. Errata in JAMA 1988; 259: 3274, and JAMA 1988; 260: 926.
3. Bhawan J, Gonzalez-Serva A, Nehal K, Labadie R, Lufrano L, Thorne EG, et al: Effects of tretinoin on photodamaged skin. A histologic study. Arch Dermatol 1991; 127: 666-672. Erratum in Arch Dermatol 1991; 127: 1382.
4. Rafal ES, Griffiths CE, Ditre CM, Finkel LJ, Hamilton TA, Ellis CN, et al: Topical tretinoin (retinoic acid) treatment for liver spots associated with photodamage. N Engl J Med 1992; 6: 368-374.
5. Thom E: A randomized placebo-controlled double-blind study in the treatment of aging symptoms of the skin. J Appl Cosmetol 1999; 17: 11-17.
6. Devaraj S, Vega-Lopez S, Koul N, Schonlau F, Rohdewald P, Jialal I: Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 2002; 37: 931-934.
7. Shigenaga MK, Hagen TM, Ames BN: Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A 1994; 91: 10771-10778.
8. Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, et al: (R)-Alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J 1999; 13: 411-418.
9. Beitner H: Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin. Br J Dermatol 2003; 149: 841-849.