Kinetic studies of yeast polyA polymerase indicate an induced fit mechanism for nucleotide specificity

Biochemistry

Volumn 44, Issue 21, 2005, Pages 7777-7786

  Balbo, Paul B ^a   Meinke, Gretchen ^a   Bohm, Andrew ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DESTABILIZATION MECHANISMS; NUCLEOTIDES; POLYADENYLATE POLYMERASE (PAP); REVERSE REACTIONS;

ADENOSINETRIPHOSPHATE; CATALYSIS; COMPLEXATION; ORGANIC POLYMERS; REACTION KINETICS; RNA; SYNTHESIS (CHEMICAL); YEAST;

ENZYMES;

ADENOSINE TRIPHOSPHATE; CYTIDINE TRIPHOSPHATE; NUCLEOTIDE; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; SULFUR;

ACCELERATION; ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL REACTION; ENZYME BINDING; ENZYME STRUCTURE; EQUILIBRIUM CONSTANT; INHIBITION KINETICS; KINETICS; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; STEADY STATE; THERMODYNAMICS; VELOCITY; YEAST;

ADENOSINE TRIPHOSPHATE; BINDING, COMPETITIVE; CYTIDINE TRIPHOSPHATE; DIPHOSPHATES; ENZYME INHIBITORS; ENZYME STABILITY; KINETICS; MAGNESIUM COMPOUNDS; MODELS, CHEMICAL; POLY A; POLYADENYLATION; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY; SULFUR; THERMODYNAMICS;

EID: 19644361850     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050089r     Document Type: Article

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