Synthesis of β3 adrenergic receptor agonist LY377604 and its metabolite 4-hydroxycarbazole, labeled with carbon-14 and deuterium

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 48, Issue 6, 2005, Pages 407-419

  Czeskis, Boris A ^a   Wheeler, William J ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

4 hydroxycarbazole; Carbon 14 labeled; Deuterium labeled; LY377604 succinate; 3 adrenergic agonist

Indexed keywords

CARBON; CHLORINE COMPOUNDS; CYCLIZATION; ZINC CHLORIDE;

4-HYDROXYCARBAZOLE; ADRENERGIC RECEPTORS; CARBON 14; CARBON-14-LABELED; CYCLIZATIONS; DEUTERIUM-LABELED; LY377604 SUCCINATE; PHENYLHYDRAZINE; PHENYLHYDRAZONES; Β3 ADRENERGIC AGONIST;

DEUTERIUM;

2,3 DICHLORO 1,3 DICYANO 1,4 BENZOQUINONE; 4 HYDROXYCARBAZOLE; ANILINE; BENZOQUINONE DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BROMIDE; CARAZOLOL; CARBAZOLE DERIVATIVE; CARBON 14; CARVEDILOL; CYCLOHEXANE; DEUTERIUM; DIHYDRORESORCINOL; LY 377604; N BROMOSUCCINIMIDE; PALLADIUM; PHENYLHYDRAZINE; PHENYLHYDRAZONE DERIVATIVE; RADIOISOTOPE; SILICA GEL; SODIUM SULFITE; TIN CHLORIDE; UNCLASSIFIED DRUG; ZINC CHLORIDE;

AROMATIZATION; ARTICLE; BROMINATION; CARBONYLATION; CATALYSIS; CYCLIZATION; DEHYDROGENATION; DIAZOTIZATION; DRUG LABELING; DRUG STRUCTURE; DRUG SYNTHESIS; FISCHER CYCLIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REPRODUCIBILITY;

EID: 19544392696     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.935     Document Type: Article

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