Evaluation and management of the acutely dyspneic patient: The role of biomarkers

American Journal of Emergency Medicine

Volumn 23, Issue 3, 2005, Pages 371-378

  Harrison, Alex ^a,c   Amundson, Stanley ^a,b  

^a SCRIPPS MERCY HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Biosite Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; CREATINE KINASE MB; D DIMER; MYOGLOBIN; TROPONIN I;

ACUTE HEART INFARCTION; BLOOD CLOT LYSIS; CLINICAL FEATURE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONGESTIVE HEART FAILURE; CONTRAST ENHANCEMENT; COST EFFECTIVENESS ANALYSIS; DEEP VEIN THROMBOSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC TEST; DISEASE MARKER; DOPPLER FLOWMETRY; DYSPNEA; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; LUNG EMBOLISM; LUNG VENTILATION PERFUSION RATIO; MEDICAL INFORMATION; PRIORITY JOURNAL; PROGNOSIS; RADIOIMMUNOASSAY; REVIEW; SPIRAL COMPUTER ASSISTED TOMOGRAPHY;

EID: 19544379192     PISSN: 07356757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajem.2005.02.017     Document Type: Article

References (88)

1. P. Meek, and R. Schwatzstein Dyspnea. Mechanisms, assessment, and management: a consensus statement. American Thoracic Society Am J Respir Crit Care Med 159 1999 321
2. P.M. Simon, R.M. Schwartzstein, and J.W. Weiss Distinguishable types of dyspnea in patients with shortness of breath Am Rev Respir Dis 142 1990 1009
3. M.L. Moy, J. Woodrow Weiss, and D. Sparrow Quality of dyspnea in bronchoconstriction differs from external resistive loads Am J Respir Crit Care Med 162 2000 451
4. R. Loudon, and R.L. Murphy Jr. Lung sounds Am Rev Respir Dis 130 4 1984 663 673
5. S.A. Sahn, and J.E. Heffner Spontaneous pneumothorax N Engl J Med 342 2000 868
6. F. Al-Bazzaz, H. Grillo, and H. Kazemi Response to exercise in upper airway obstruction Am Rev Respir Dis 111 5 1975 631 640
7. A.P. Davie, C.M. Francis, and L. Caruana Assessing diagnosis in heart failure: which features are any use? QJM 90 1997 335
8. S. Morgan, H. Smith, and I. Simpson Prevalence and clinical characteristics of left ventricular dysfunction among elderly patients in general practice setting: cross sectional survey BMJ 318 1999 368
9. H.B. Wheeler Diagnosis of deep venous thrombosis: review of clinical evaluation and impedance plethysmography Am J Surg 150 Suppl. 1985 7
10. J.R. Leclerc, F. Illescas, and P. Jarzem Diagnosis of deep vein thrombosis J.R. Leclerc Venous thromboembolic disorders 1991 Lea Febiger Philadelphia 176
11. T.J. Ryan, E.M. Antman, and N.H. Brooks 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction: executive summary and recommendations. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction) Circulation 100 1999 1016
12. M.S. Sabatine, D.A. Morrow, and J.A. de Lemos Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: simultaneous assessment of troponin I. C-reactive protein, and B-type natriuretic peptide Circulation 105 15 2002 1760 1763
13. K.T. Horlander, D.M. Mannino, and K.V. Leeper Pulmonary embolism mortality in the United States, 1979-1998: an analysis using multiple-cause mortality data Arch Intern Med 163 2003 1711
14. S.E. Dismuke, and E.H. Wagner Pulmonary embolism as a cause of death. The changing mortality in hospitalized patients JAMA 255 1986 2039
15. J.E. Dalen, and J.S. Alpert Natural history of pulmonary embolism Prog Cardiovasc Dis 17 1975 257
16. V.F. Tapson W.J. Fulkerson H.A. Saltzman Venous thromboembolism Clin Chest Med 16 1995 229
17. J.L. Carson, M.A. Kelley, and A. Duff The clinical course of pulmonary embolism: one year follow-up of PIOPED patients N Engl J Med 326 1992 1240
18. S.Z. Goldhaber Pulmonary embolism N Engl J Med 339 1998 93
19. K.M. Moser Venous thromboembolism Am Rev Respir Dis 141 1990 235
20. S.Z. Goldhaber, L. Visani, and M. De Rosa Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER) Lancet 353 1999 1386
21. A. Perrier Non-invasive diagnosis of venous thromboembolism in outpatients Lancet 353 9148 1999 190 195
22. S.Z. Goldhaber, G.R. Simons, and C.G. Elliott Quantitative plasma d-dimer levels among patients undergoing pulmonary angiography for suspected pulmonary embolism JAMA 270 1993 2819
23. P. Egermayer, G.I. Town, and J.G. Turner Usefulness of d-dimer, blood gas, and respiratory rate measurements for excluding pulmonary embolism Thorax 53 1998 830
24. J.S. Ginsberg, P.S. Wells, and C. Kearon Sensitivity and specificity of a rapid whole-blood assay for d-dimer in the diagnosis of pulmonary embolism Ann Intern Med 129 1998 1006
25. J.T. Owings, and R.C. Gosselin Whole blood d-dimer assay: an effective noninvasive method to rule out pulmonary embolism J Trauma Inj Infect Crit Care 48 5 2000 795 800
26. F. Turkstra, E.J.R. van Beek, J.W. ten Cate, and H.R. Büller Reliable rapid blood test for the exclusion of venous thromboembolism in symptomatic outpatients Thromb Haemost 76 1 1996 9 11
27. E. Oger, C. Leroyer, and L. Bressollette Evaluation of a new, rapid, and quantitative d-dimer test in patients with suspected pulmonary embolism Am J Respir Crit Care Med 158 1998 65
28. A. Perrier, S. Desmarais, and M.J. Miron Non-invasive diagnosis of venous thromboembolism in outpatients Lancet 353 1999 190
29. M.R. de Groot, M. van Marwijk Kooy, and J.G. Pouwels The use of a rapid d-dimer blood test in the diagnostic work-up for pulmonary embolism: a management study Thromb Haemost 82 1999 1588
30. K.L. Dunn, J.P. Wolf, D.M. Dorfman, and P. Fitzpatrick Normal d-dimer levels in emergency department patients suspected of acute pulmonary embolism J Am Coll Cardiol 40 2002 1475
31. J.A. Kline, and P.S. Wells Methodology for a rapid protocol to rule out pulmonary embolism in the emergency department Ann Emerg Med 42 2 2003 266 275
32. T. Meyer, L. Binder, and N. Hruska Cardiac troponin I elevation in acute pulmonary embolism is associated with right ventricular dysfunction J Am Coll Cardiol 36 2000 1632
33. E. Giannitsis, M. Muller-Bardorff, and V. Kurowski Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism Circulation 102 2000 211
34. P. Pruszczyk, A. Bochowicz, and A. Torbicki Cardiac troponin T monitoring identifies high-risk group of normotensive patients with acute pulmonary embolism Chest 123 2003 1947
35. S. Konstantinides, A. Geibel, and M. Olschewski Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism Circulation 106 2002 1263
36. J.D. Douketis, M.A. Crowther, E.B. Stanton, and J.S. Ginsberg Elevated cardiac troponin levels in patients with submassive pulmonary embolism Arch Intern Med 162 2002 79
37. K.T. Horlander, and K.V. Leeper Troponin levels as a guide to treatment of pulmonary embolism Curr Opin Pulm Med 9 2003 374
38. K. Janata, M. Holzer, A.N. Laggner, and M. Mullner Cardiac troponin T in the severity assessment of patients with pulmonary embolism: cohort study BMJ 326 2003 312
39. A. Maisel B-type natriuretic peptide levels: diagnostic and prognostic in congestive heart failure: what's next? Circulation 105 2002 2328
40. M. ten Wolde, I.I. Tulevski, and J.W. Mulder Brain natriuretic peptide as a predictor of adverse outcome in patients with pulmonary embolism Circulation 107 2003 2082
41. N. Kucher, G. Printzen, and T. Doernhoefer Low pro-brain natriuretic peptide levels predict benign clinical outcome in acute pulmonary embolism Circulation 107 2003 1576
42. N. Kucher, G. Printzen, and S.Z. Goldhaber Prognostic role of brain natriuretic peptide in acute pulmonary embolism Circulation 107 20 2003 2545 2547 [Electronic publication 2003 May 12]
43. A.S. Maisel, P. Krishnaswamy, and R.M. Nowak Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure N Engl J Med 347 2002 161
44. M.D. Nils Kucher, and M.D. Gert Printzen Prognostic role of brain natriuretic peptide in acute pulmonary embolism Circulation 107 2003 2545
45. L. Mascitelli, and F. Pezzetta Thrombolysis in the treatment of submassive pulmonary embolism Arch Intern Med 163 10 2003 1238
46. S.M. Arcasoy, and A. Vachani Local and systemic thrombolytic therapy for acute venous thromboembolism Clin Chest Med 24 1 2003 73 91 [Review]
47. S. Konstantinides The case for thrombolysis in acute major pulmonary embolism: hemodynamic benefits and beyond Intensive Care Med 28 11 2002 1547 1551 [Review]
48. G. Agnelli, C. Becattini, and T. Kirschstein Thrombolysis vs heparin in the treatment of pulmonary embolism: a clinical outcome-based meta-analysis Arch Intern Med 162 22 2002 2537 2541
49. S. Konstantinides, A. Geibel, G. Heusel, F. Heinrich, and W. Kasper Management strategies and prognosis of pulmonary embolism-3 trial investigators. Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism N Engl J Med 347 15 2002 1143 1150
50. J. Herrmann, and L. Volbracht Biochemical markers of ischemic and non-ischemic myocardial damage Med Klin (Munich) 96 3 2001 144 156
51. O. Topolcan, and A. Polivkova The significance of myoglobin determination in the differential diagnosis of chest pain syndrome Vnitr Lek 37 4 1991 330 335
52. L.J. Kagen Myoglobin: biochemical, physiological and clinical aspects 1973 Columbia Univ Press New York
53. F.J. Klocke, D.P. Copley, J.A. Krawszyk, and M. Reichlin Rapid renal clearance of immunoreactive canine plasma myoglobin Circulation 65 1982 1522
54. J. Zimmerman, R. Fromm, and D. Meyer Diagnostic Marker Cooperative study for the diagnosis of myocardial infarction Circulation 99 1999 1671
55. J. McCord, R.M. Nowak, and P.A. McCullough Ninety-minute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I Circulation 104 2001 1483
56. L.K. Newby, A.B. Storrow, and W.B. Gibler Bedside multimarker testing for risk stratification in chest pain units. The Chest Pain Evaluation by Creatine Kinase-MB. Myoglobin, and Troponin I (CHECKMATE) study Circulation 103 2001 1832
57. R. Roberts Myoglobinemia as an index to myocardial infarction Ann Intern Med 87 1977 788
58. J.E. Hollander, A. Levitt, and G.P. Young Effect of recent cocaine use on the specificity of markers for diagnosis of acute myocardial infarction Am Heart J 135 1998 245
59. J. Zimmerman, R. Fromm, and D. Meyer Diagnostic Marker Cooperative study for the diagnosis of myocardial infarction Circulation 99 1999 1671
60. A.S. Jaffe 2001-A biomarker odyssey Clin Chim Acta 284 2 1999 197 211
61. C.W. Hamm, B. Goldmann, and C. Heeshen Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I N Engl J Med 337 1997 1648
62. J.A. de Lemos, and D.A. Morrow Combining natriuretic peptides and necrosis markers in the assessment of acute coronary syndromes Rev Cardiovasc Med 4 Suppl. 4 2003 S37 S47 [Review]
63. G. Leroy, and L. Uzan The value of repeated determinations of brain natriuretic peptide for the diagnosis of unstable angina Arch Mal Coeur Vaiss 96 4 2003 305 310
64. D.A. Morrow, J.A. de Lemos, and M.S. Sabatine Evaluation of B-type natriuretic peptide for risk assessment in unstable angina/non-ST-elevation myocardial infarction: B-type natriuretic peptide and prognosis in TACTICS-TIMI 18 J Am Coll Cardiol 41 8 2003 1264 1272 [Erratum in: J Am Coll Cardiol 2003 May 21;41(10):1852]
65. T. Omland, and A. Persson N-terminal pro-B-type natriuretic peptide and long-term mortality in acute coronary syndromes Circulation 106 23 2002 2913 2918
66. N. Hama, and H. Itoh Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction Circulation 922 1995 1558 1564
67. T. Omland, and A. Aakvaag Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long-term survival after acute myocardial infarction. Comparison with plasma atrial natriuretic peptide and N-terminal proatrial natriuretic peptide Circulation 93 1996 1963 1969
68. A.M. Richards, and M.G. Nichols B-type natriuretic peptides and ejection fraction for prognosis after myocardial infarction Circulation 107 2003 2786 2792
69. J.A. de Lemos, and D.A. Morrow The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes N Engl J Med 345 2001 1012 1021
70. L.E. Rabbani Acute coronary syndromes-beyond myocyte necrosis N Engl J Med 345 2001 1057 1059
71. J. Figueras, Y. Monasterio, and R.M. Lidon Thrombin formation and fibrinolytic activity in patients with acute myocardial infarction or unstable angina: in-hospital course and relationship with recurrent angina at rest J Am Coll Cardiol 36 2000 2036
72. M.D. Flather, J.I. Weitz, and S. Yusuf Reactivation of coagulation after stopping infusions of recombinant hirudin and unfractionated heparin in unstable angina and myocardial infarction without ST elevation: results of a randomized trial. OASIS Pilot Study Investigators. Organization to Assess Strategies for Ischemic Syndromes Eur Heart J 21 2000 1473
73. P. Kinnunen, O. Vuolteenaho, and H. Ruskoaho Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: Effect of stretching Endocrinology 132 1993 1961
74. O.W. Nielsen, T.A. McDonagh, S.D. Robb, and H.J. Dargie Retrospective analysis of the cost-effectiveness of using plasma brain natriuretic peptide in screening for left ventricular systolic dysfunction in the general population J Am Coll Cardiol 41 2003 113
75. B. Stanek, B. Frey, and M. Hulsmann Prognostic evaluation of neurohumoral plasma levels before and during beta-blocker therapy in advanced left ventricular dysfunction J Am Coll Cardiol 38 2001 436
76. J. Koglin, S. Pehlivanli, and M. Schwaiblmair Role of brain natriuretic peptide in risk stratification of patients with congestive heart failure J Am Coll Cardiol 38 2001 1934
77. I.S. Anand, L.D. Fisher, and Y.T. Chiang Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan Heart Failure Trial (Val-HeFT) Circulation 107 2003 1278
78. A. Maisel Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting J Am Coll Cardiol 37 2 2001 379 385
79. Task Force for the Diagnosis and Treatment of Chronic Heart Failure, European Society of Cardiology Guidelines for the diagnosis and treatment of chronic heart failure Eur Heart J 22 2001 1527 1560 [Erratum, Eur Heart J 2001;22:2217-8]
80. A. Harrison B-type natriuretic peptide predicts future cardiac events in patients presenting to the emergency department with dyspnea Ann Emerg Med 39 2 2002 131 138
81. R. Kazanegra, V. Cheng, A. Garcia, P. Krishnaswamy, N. Gardetto, and P. Clopton A rapid assay for B-type natriuretic peptide correlates with falling wedge pressures in patients treated for decompensated heart failure: a pilot study J Card Fail 7 1 2001 21 29
82. M.R. Cowie, A.D. Struthers, and D.A. Wood Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care Lancet 350 1997 1349 1353
83. P. Bettencourt Prognostic information provided by serial measurements of brain natriuretic peptide in heart failure Int J Cardiol 93 1 2004 45 48
84. C. Mueller, and A. Scholer Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea N Engl J Med 350 2004 647 654
85. P.J. Hunt, A.M. Richards, and M.G. Nicholls Immunoreactive amino-terminal pro-brain natriuretic peptide (NT-PROBNP): a new marker of cardiac impairment Clin Endocrinol (Oxf) 47 1997 287
86. T. Jernberg, M. Stridsberg, P. Venge, and B. Lindahl N-terminal pro brain natriuretic peptide on admission for early risk stratification of patients with chest pain and no ST-segment elevation J Am Coll Cardiol 40 2002 437
87. A.M. Richards, M.G. Nicholls, and T.G. Yandle Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: new neurohormonal predictors of left ventricular function and prognosis after myocardial infarction Circulation 97 1998 1921
88. T. Omland, A. Persson, and L. Ng N-terminal pro-B-type natriuretic peptide and long-term mortality in acute coronary syndromes Circulation 106 2002 2913